Post-renal transplantation hypophosphatemia

Pediatric Nephrology

Volumn 25, Issue 2, 2010, Pages 213-220

  Sakhaee, Khashayar ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bone disease; Hypophosphatemia; Phosphorus wasting; Post renal transplantation

Indexed keywords

CALCITRIOL; FIBROBLAST GROWTH FACTOR 23; PARATHYROID HORMONE; PHOSPHORUS; STEROID; TACROLIMUS; IMMUNOSUPPRESSIVE AGENT; PHOSPHATE;

BONE DISEASE; DRUG MEGADOSE; HUMAN; HYPERPARATHYROIDISM; HYPOPHOSPHATEMIA; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; NONHUMAN; PARATHYROID HORMONE BLOOD LEVEL; PATHOPHYSIOLOGY; PHOSPHATE METABOLISM; PHOSPHATE URINE LEVEL; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVIEW; VITAMIN BLOOD LEVEL; WASTING SYNDROME; ADULT; BLOOD; CHILD; PATHOLOGIC FRACTURE; PHYSIOLOGY; RENAL OSTEODYSTROPHY;

ADULT; CHILD; FRACTURES, SPONTANEOUS; HUMANS; HYPOPHOSPHATEMIA; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; PARATHYROID HORMONE; PHOSPHATES; POSTOPERATIVE COMPLICATIONS; RENAL OSTEODYSTROPHY;

EID: 77950492943     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-009-1252-4     Document Type: Review

References (82)

1. Papalois VE, Najarian JS (2001) Pediatric kidney transplantation: Historic hallmarks and a personal perspective. Pediatr Transplant 5:239-245
2. Calne RY, White DJ, Thiru S, Evans DB, McMaster P, Dunn DC, Craddock GN, Pentlow BD, Rolles K (1978) Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet 2:1323-1327 (Pubitemid 9078430)
3. Goldstein G, Kremer AB, Barnes L, Hirsch RL (1987) OKT3 monoclonal antibody reversal of renal and hepatic rejection in pediatric patients. J Pediatr 111:1046-1050 (Pubitemid 18024935)
4. Jensen CW, Jordan ML, Schneck FX, Shapiro R, Tzakis A, Hakala TR, Starzl TE (1991) Pediatric renal transplantation under FK 506 immunosuppression. Transplant Proc 23:3075-3077
5. Vincenti F, Kirkman R, Light S, Bumgardner G, Pescovitz M, Halloran P, Neylan J,WilkinsonA, Ekberg H,Gaston R, Backman L, Burdick J (1998) Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group. N Engl J Med 338:161-165
6. Saland JM (2004) Osseous complications of pediatric transplantation. Pediatr Transplant 8:400-415
7. Sanchez CP, Salusky IB, Kuizon BD, Ramirez JA, Gales B, Ettenger RB, Goodman WG (1998) Bone disease in children and adolescents undergoing successful renal transplantation. Kidney Int 53:1358-1364 (Pubitemid 28316899)
8. Smets YF, van der Pijl JW, de Fijter JW, Ringers J, Lemkes HH, Hamdy NA (1998) Low bone mass and high incidence of fractures after successful simultaneous pancreas-kidney transplantation. Nephrol Dial Transplant 13:1250-1255 (Pubitemid 28227206)
9. Vautour LM, Melton LJ 3rd, Clarke BL, Achenbach SJ, Oberg AL, McCarthy JT (2004) Long-term fracture risk following renal transplantation: A population-based study. Osteoporos Int 15:160-167 (Pubitemid 38252430)
10. Ghanekar H, Welch BJ, Moe OW, Sakhaee K (2006) Post-renal transplantation hypophosphatemia: A review and novel insights. Curr Opin Nephrol Hypertens 15:97-104 (Pubitemid 43755811)
11. Epstein S (1996) Post-transplantation bone disease: The role of immunosuppressive agents and the skeleton. J Bone Miner Res 11:1-7 (Pubitemid 26026737)
12. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC (1998) Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 102:274-282
13. Vega D, Sakhaee K (2007) Osteoporosis following solid organ transplantation. Future Rheumatol 2:341-345 (Pubitemid 47250165)
14. Shane E, Rivas M, Staron RB, Silverberg SJ, Seibel MJ, Kuiper J, Mancini D, Addesso V, Michler RE, Factor-Litvak P (1996) Fracture after cardiac transplantation: A prospective longitudinal study. J Clin Endocrinol Metab 81:1740-1746 (Pubitemid 26152456)
15. Ninkovic M, Skingle SJ, Bearcroft PW, Bishop N, Alexander GJ, Compston JE (2000) Incidence of vertebral fractures in the first three months after orthotopic liver transplantation. Eur J Gastroenterol Hepatol 12:931-935 (Pubitemid 30663906)
16. Takeda E, Taketani Y, Sawada N, Sato T, Yamamoto H (2004) The regulation and function of phosphate in the human body. Biofactors 21:345-355 (Pubitemid 40921881)
17. Levi M, Kempson SA, Lotscher M, Biber J, Murer H (1996) Molecular regulation of renal phosphate transport. J Membr Biol 154:1-9 (Pubitemid 26405606)
18. Biber J, Custer M, Werner A, Kaissling B, Murer H (1993) Localization of NaPi-1, a Na/Pi cotransporter, in rabbit kidney proximal tubules. II. Localization by immunohistochemistry. Pflugers Arch 424:210-215 (Pubitemid 23227673)
19. Custer M, Lotscher M, Biber J, Murer H, Kaissling B (1994) Expression of Na-P(I) cotransport in rat kidney: Localization by RT-PCR and immunohistochemistry. Am J Physiol 266:F767-F774 (Pubitemid 24170689)
20. Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, Tatsumi S, Miyamoto K (2002) Growth-related renal type II Na/Pi cotransporter. J Biol Chem 277:19665-19672 (Pubitemid 34967481)
21. Hilfiker H, Hattenhauer O, Traebert M, Forster I, Murer H, Biber J (1998) Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Proc Natl Acad Sci USA 95:14564-14569 (Pubitemid 28549407)
22. Murer H, Hernando N, Forster I, Biber J (2000) Proximal tubular phosphate reabsorption: Molecular mechanisms. Physiol Rev 80:1373-1409
23. Tenenhouse HS (2007) Phosphate transport: Molecular basis, regulation and pathophysiology. J Steroid Biochem Mol Biol 103:572-577 (Pubitemid 46401356)
24. Berndt TJ, Schiavi S, Kumar R (2005) "Phosphatonins" and the regulation of phosphorus homeostasis. Am J Physiol Renal Physiol 289:F1170-F1182
25. Yan X, Yokote H, Jing X, Yao L, Sawada T, Zhang Y, Liang S, Sakaguchi K (2005) Fibroblast growth factor 23 reduces expression of type IIa Na+/Pi co-transporter by signaling through a receptor functionally distinct from the known FGFRs in opossum kidney cells. Genes Cells 10:489-502 (Pubitemid 40590366)
26. Levi M, Shayman JA, Abe A, Gross SK, McCluer RH, Biber J, Murer H, Lötscher M, Cronin RE (1995) Dexamethasone modulates rat renal brush border membrane phosphate transporter mRNA and protein abundance and glycosphingolipid composition. J Clin Invest 96:207-216
27. Alcalde AI, Sarasa M, Raldua D, Aramayona J, Morales R, Biber J, Murer H, Levi M, Sorribas V (1999) Role of thyroid hormone in regulation of renal phosphate transport in young and aged rats. Endocrinology 140:1544-1551 (Pubitemid 29149220)
28. Ambuhl PM, Meier D, Wolf B, Dydak U, Boesiger P, Binswanger U (1999) Metabolic aspects of phosphate replacement therapy for hypophosphatemia after renal transplantation: Impact on muscular phosphate content, mineral metabolism, and acid/base homeostasis. Am J Kidney Dis 34:875-883 (Pubitemid 29521704)
29. Levi M (2001) Post-transplant hypophosphatemia. Kidney Int 59:2377-2387 (Pubitemid 32467638)
30. Felsenfeld AJ, Gutman RA, Drezner M, Llach F (1986) Hypophosphatemia in long-term renal transplant recipients: Effects on bone histology and 1, 25-dihydroxycholecalciferol. Miner Electrolyte Metab 12:333-341 (Pubitemid 17002640)
31. Portale AA, Halloran BP, Morris RC Jr (1989) Physiologic regulation of the serum concentration of 1, 25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest 83:1494-1499
32. Green J, Debby H, Lederer E, Levi M, Zajicek HK, Bick T (2001) Evidence for a PTH-independent humoral mechanism in posttransplant hypophosphatemia and phosphaturia. Kidney Int 60:1182-1196 (Pubitemid 34205819)
33. Heaney RP, Abrams S, Dawson-Hughes B, Looker A, Marcus R, Matkovic V, Weaver C (2000) Peak bone mass. Osteoporos Int 11:985-1009 (Pubitemid 32144591)
34. GarabedianM, Silve C, Levy D, Bourdeau A, Ulmann A, Broyer M, Balsan S (1980) Chronic hypophosphatemia in kidney transplanted children and young adults. Adv Exp Med Biol 128:249-254
35. Brodehl J, Krause A, Hoyer PF (1988) Assessment of maximal tubular phosphate reabsorption: Comparison of direct measurement with the nomogram of Bijvoet. Pediatr Nephrol 2:183-189
36. Bernheim J, Touraine JL, David L, Faivre JM, Traeger J (1976) Evolution of secondary hyperparathyroidism after renal transplantation. Nephron 16:381-387
37. Claesson K, Hellman P, Frodin L, Rastad J (1998) Prospective study of calcium homeostasis after renal transplantation. World J Surg 22:635-641, discussion 41-42 (Pubitemid 28215444)
38. Rosenbaum RW, Hruska KA, Korkor A, Anderson C, Slatopolsky E (1981) Decreased phosphate reabsorption after renal transplantation: Evidence for a mechanism independent of calcium and parathyroid hormone. Kidney Int 19:568-578 (Pubitemid 11120903)
39. Salusky IB, Coburn JW, Brill J, Foley J, Slatopolsky E, Fine RN, Goodman WG (1988) Bone disease in pediatric patients undergoing dialysis with CAPD or CCPD. Kidney Int 33:975-982
40. Salusky IB, Ramirez JA, Oppenheim W, Gales B, Segre GV, Goodman WG (1994) Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD. Kidney Int 45:253-258 (Pubitemid 24046016)
41. Graf H, Kovarik J, Stummvoll HK, Wolf A, Pinggera WF (1979) Handling of phosphate by the transplanted kidney. Proc Eur Dial Transplant Assoc 16:624-629
42. Parfitt AM, Kleerekoper M, Cruz C (1986) Reduced phosphate reabsorption unrelated to parathyroid hormone after renal transplantation: Implications for the pathogenesis of hyperparathyroidism in chronic renal failure. Miner Electrolyte Metab 12: 356-362 (Pubitemid 17002644)
43. White KE, Jonsson KB, Carn G, Hampson G, Spector TD, Mannstadt M, Lorenz-Depiereux B, Miyauchi A, Yang IM, Ljunggren O, Meitinger T, Strom TM, Jüppner H, Econs MJ (2001) The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting. J Clin Endocrinol Metab 86:497-500 (Pubitemid 32207449)
44. Jonsson KB, Zahradnik R, Larsson T, White KE, Sugimoto T, Imanishi Y, Yamamoto T, Hampson G, Koshiyama H, Ljunggren O, Oba K, Yang IM, Miyauchi A, Econs MJ, Lavigne J, Jüppner H (2003) Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med 348:1656-1663 (Pubitemid 36459471)
45. White KE, Evans WE, O'Riordan J, Speer MC, Econs MJ, Lorenz-Depiereux B, Grabowski M, Meitinger T, Strom TM (2000) Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 26:345-348
46. Riancho JA, de Francisco AL, del Arco C, Amado JA, Cotorruelo JG, Arias M, Gonzalez-Macias J (1988) Serum levels of 1, 25-dihydroxyvitamin D after renal transplantation. Miner Electrolyte Metab 14:332-337 (Pubitemid 18261583)
47. Steiner RW, Ziegler M, Halasz NA, Catherwood BD, Manolagas S, Deftos LJ (1993) Effect of daily oral vitamin D and calcium therapy, hypophosphatemia, and endogenous 1-25 dihydroxycholecalciferol on parathyroid hormone and phosphate wasting in renal transplant recipients. Transplantation 56:843-846 (Pubitemid 23321515)
48. Bhan I, Shah A, Holmes J, Isakova T, Gutierrez O, Burnett SM, Jüppner H, Wolf M (2006) Post-transplant hypophosphatemia: Tertiary 'hyper-phosphatoninism'? Kidney Int 70:1486-1494 (Pubitemid 44527320)
49. Imanishi Y, Inaba M, Nakatsuka K, Nagasue K, Okuno S, Yoshihara A, Miura M, Miyauchi A, Kobayashi K, Miki T, Shoji T, Ishimura E, Nishizawa Y (2004) FGF-23 in patients with endstage renal disease on hemodialysis. Kidney Int 65:1943-1946 (Pubitemid 38591047)
50. Yu X, Ibrahimi OA, Goetz R, Zhang F, Davis SI, Garringer HJ, Linhardt RJ, Ornitz DM, Mohammadi M, White KE (2005) Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology 146:4647-4656 (Pubitemid 41446602)
51. Imel EA, Econs MJ (2005) Fibroblast growth factor 23: Roles in health and disease. J Am Soc Nephrol 16:2565-2575
52. Itoh N, Ornitz DM (2004) Evolution of the Fgf and Fgfr gene families. Trends Genet 20:563-569 (Pubitemid 39314564)
53. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770-774 (Pubitemid 44949607)
54. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-o M (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281:6120-6123 (Pubitemid 43847540)
55. Liu S, Vierthaler L, Tang W, Zhou J, Quarles LD (2008) FGFR3 and FGFR4 do not mediate renal effects of FGF23. J Am Soc Nephrol 19:2342-2350
56. Baum M, Syal A, Quigley R, Seikaly M (2006) Role of prostaglandins in the pathogenesis of X-linked hypophosphatemia. Pediatr Nephrol 21:1067-1074 (Pubitemid 44083877)
57. Wang H, Yoshiko Y, Yamamoto R, Minamizaki T, Kozai K, Tanne K, Aubin JE, Maeda N (2008) Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro. J Bone Miner Res 23:939-948 (Pubitemid 351768812)
58. Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, Takeuchi Y, Fujita T, Nakahara K, Fukumoto S, Yamashita T (2004) FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19:429-435 (Pubitemid 38787398)
59. Gupta A, Winer K, Econs MJ, Marx SJ, Collins MT (2004) FGF- 23 is elevated by chronic hyperphosphatemia. J Clin Endocrinol Metab 89:4489-4492
60. Ferrari SL, Bonjour JP, Rizzoli R (2005) Fibroblast growth factor- 23 relationship to dietary phosphate and renal phosphate handling in healthy young men. J Clin Endocrinol Metab 90:1519-1524 (Pubitemid 40464013)
61. Larsson T, Nisbeth U, Ljunggren O, Juppner H, Jonsson KB (2003) Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int 64:2272-2279 (Pubitemid 37449564)
62. Shigematsu T, Kazama JJ, Yamashita T, Fukumoto S, Hosoya T, Gejyo F, Fukagawa M (2004) Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency. Am J Kidney Dis 44:250-256 (Pubitemid 38962552)
63. Sato T, Tominaga Y, Ueki T, Goto N, Matsuoka S, Katayama A, Haba T, Uchida K, Nakanishi S, Kazama JJ, Gejyo F, Yamashita T, Fukagawa M (2004) Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism. Am J Kidney Dis 44:481-487 (Pubitemid 39164625)
64. Gutierrez O, Isakova T, Rhee E, Shah A, Holmes J, Collerone G, Jüppner H, Wolf M (2005) Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol 16:2205-2215 (Pubitemid 41716454)
65. Wesseling-Perry K, Pereira RC, Wang H, Elashoff RM, Sahney S, Gales B, Jüppner H, Salusky IB (2009) Relationship between plasma fibroblast growth factor-23 concentration and bone mineralization in children with renal failure on peritoneal dialysis. J Clin Endocrinol Metab 94:511-517
66. Pande S, Ritter CS, Rothstein M, Wiesen K, Vassiliadis J, Kumar R, Schiavi SC, Slatapolsky E, Brown AJ (2006) FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation. Nephron Physiol 104:p23-32 (Pubitemid 44238894)
67. Kawata T, Imanishi Y, Kobayashi K, Miki T, Arnold A, Inaba M, Nishizawa Y (2007) Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism. J Am Soc Nephrol 18:2683-2688 (Pubitemid 47531195)
68. Liu S, Tang W, Zhou J, Vierthaler L, Quarles LD (2007) Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice. Am J Physiol Endocrinol Metab 293:E1636-E1644 (Pubitemid 350255114)
69. Calvi LM, Sims NA, Hunzelman JL, Knight MC, Giovannetti A, Saxton JM, Kronenberg HM, Baron R, Schipani E (2001) Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J Clin Invest 107:277-286 (Pubitemid 32157960)
70. Berndt T, Craig TA, Bowe AE, Vassiliadis J, Reczek D, Finnegan R, Jan De Beur SM, Schiavi SC, Kumar R (2003) Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest 112:785-794 (Pubitemid 38057719)
71. Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (2000) MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics 67:54-68 (Pubitemid 30471121)
72. Liang CT, Barnes J, Balakir R, Cheng L, Sacktor B (1982) In vitro stimulation of phosphate uptake in isolated chick renal cells by 1, 25-dihydroxycholecalciferol. Proc Natl Acad Sci USA 79:3532-3536 (Pubitemid 12011399)
73. Kurnik BR, Hruska KA (1984) Effects of 1, 25- dihydroxycholecalciferol on phosphate transport in vitamin D-deprived rats. Am J Physiol 247:F177-F184 (Pubitemid 14091542)
74. Loffing J, Lotscher M, Kaissling B, Biber J, Murer H, Seikaly M, Alpern RJ, Levi M, Baum M, Moe OW (1998) Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states. J Am Soc Nephrol 9:1560-1567 (Pubitemid 28405061)
75. Falkiewicz K, Nahaczewska W, Boratynska M, Owczarek H, Klinger M, Kaminska D, Wozniak M, Szepietowski T, Patrzalek D (2003) Tacrolimus decreases tubular phosphate wasting in renal allograft recipients. Transplant Proc 35:2213-2215 (Pubitemid 37194368)
76. Maalouf NM, Shane E (2005) Osteoporosis after solid organ transplantation. J Clin Endocrinol Metab 90:2456-2465
77. Feller RB, McDonald JA, Sherbon KJ, McCaughan GW (1999) Evidence of continuing bone recovery at a mean of 7 years after liver transplantation. Liver Transpl Surg 5:407-413
78. Pichette V, Bonnardeaux A, Prudhomme L, Gagne M, Cardinal J, Ouimet D (1996) Long-term bone loss in kidney transplant recipients: A cross-sectional and longitudinal study. Am J Kidney Dis 28:105-114 (Pubitemid 26231474)
79. Monier-Faugere MC, Mawad H, Qi Q, Friedler RM, Malluche HH (2000) High prevalence of low bone turnover and occurrence of osteomalacia after kidney transplantation. J Am Soc Nephrol 11:1093-1099 (Pubitemid 30367939)
80. Carlini RG, Rojas E, Weisinger JR, Lopez M, Martinis R, Arminio A, Bellorin-Font E (2000) Bone disease in patients with long-term renal transplantation and normal renal function. Am J Kidney Dis 36:160-166 (Pubitemid 30432578)
81. Burckhardt P, Michel C (1989) The peak bone mass concept. Clin Rheumatol 8[Suppl 2]:16-21 (Pubitemid 20122974)
82. Seeman E (2003) Bone quality. Osteoporos Int 14[Suppl 5]: S3-7