Evaluation of Angiogenesis in Canine Mammary Tumors by Quantitative Platelet Endothelial Cell Adhesion Molecule Immunohistochemistry

Veterinary Pathology

Volumn 37, Issue 4, 2000, Pages 297-301

  Restucci, B ^a   De Vico, G ^b   Maiolino, P ^b  

^a AO Monaldi   (Italy)

^b NONE

Author keywords

Angiogenesis; Canine mammary neoplasms; Image analysis; Immunohistochemistry

Indexed keywords

CD31 ANTIGEN;

ANIMAL; ANIMAL DISEASE; ARTICLE; DOG; DOG DISEASE; EXPERIMENTAL NEOPLASM; FEMALE; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY;

ANIMALS; ANTIGENS, CD31; DOG DISEASES; DOGS; FEMALE; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MAMMARY NEOPLASMS, ANIMAL; NEOVASCULARIZATION, PATHOLOGIC;

EID: 0034222468     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.37-4-297     Document Type: Article

References (32)

1. Blood CH, Zetter BR: Tumor interaction with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta 1032:89-118, 1990
2. Charpin C, Devictor B, Bergeret D: CD31 quantitative immunocytochemical assays in breast carcinomas. Correlation with current prognostic factors. Am J Clin Pathol 103:443-448, 1995
3. Charpin C, Garcia S, Bouvier C: CD31/PECAM automated and quantitative immunocytochemical assay in breast carcinomas. Correlation with patient follow-up. Am J Clin Pathol 107:534-541, 1997
4. Ferrara N: Vascular endothelial growth factor. Trends Cardiovasc Med 3:244-250, 1993
5. Ferrer L, Fondevila D, Rabanal RM: Immunohistochemical detection of CD31 antigen in normal and neoplastic canine endothelial cells. J Comp Pathol 112:319-326, 1995
6. Fidler IJ, Ellis LM: The implications of angiogenesis for biology and therapy of cancer metastasis. Cell 79:185-188, 1994
7. Folkman J, Watson K, Ingber D: Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339:58-61, 1989
8. Folkman J: What is the evidence that tumors are angiogenesis-dependent? J Natl Cancer Inst 82:4-6, 1990
9. Folkman J, Shing Y: Angiogenesis. J Biol Chem 267: 10931-10934, 1992
10. Fox SB, Gatter KC, Bicknell R: Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer Cancer Res 53:4161-4163, 1993
11. Fox SB, Russel DL, Weekes MP: Quantitation and prognostic value of angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol 177:275-283, 1995
12. Fox SB, Gatter KC, Harris AL: Tumour angiogenesis. J Pathol 179:232-237, 1996
13. Giatromanolaki A, Koukourakis M, O'Byrne K: Prognostic value of angiogenesis in operable non-small cell lung cancer. J Pathol 179:80-88, 1996
14. Gimbrone MAJ, Leapman SB, Cotran RS: Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136:261-276, 1972
15. Hampe JF, Misdorp W: Tumours and dysplasia of the mammary gland. Bull World Health Organ 50:111-113, 1974
16. Hanahan D, Folkman J: Patterns and emerging mechanism of the angiogenis switch during tumorigenesis. Cell 86:353-364, 1996
17. Hobson B, Denekamp J: Endothelial cell proliferation in tumours and normal tissues: continuous labelling studies. Br J Canc 49:405-413, 1984
18. Jacquemier JD, Penault-Llorca FM, Bertucci F: Angiogenesis as a prognostic marker in breast carcinoma and conventional adjuvant chemotherapy: a multiparametric and immunohistochemical analysis. J Pathol 184: 130-135, 1998
19. Misdorp W: Histologic classification and further characterization of tumours in domestic animals. Adv Vet Sci Comp Med 20:191-221, 1976
20. Moscatelli D, Gross J, Rifkin D: Ángiogenic factors stimulate plasminogen activator and collagenase production by capillary endothelial cells. J Cell Biol 91:120a, 1981
21. Newman PJ, Berndt MC, Gorski J: PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 247:1219-1222, 1990
22. Olivarez D, Ulbright T, DeRiese W: Neovascularization in clinical stage A testicular germ tumor: prediction of metastatic disease. Cancer 78:226-231, 1996
23. Olofsson B, Pajusola K, Kaipainen A: Vascular endothelial growth actor B, a novel growth factor for endothelial cells. Proc Natl Acad Sci USA 93:2576-2581, 1996
24. O'Reilly MS, Holmgren L, Shing Y: Angiostatin: a novel angiogenesis inhibitor mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79:315-328, 1994
25. Parums DV, Cordell JL, Micklem F: JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol 43:752-757, 1990
26. Pazouki S, Chisholm DM, Adi MM: The association between tumour progression and vascularity in the oral mucosa. J Pathol 183:39-43, 1997
27. Srivastava A, Laidler P, Davies R: The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. Am J Pathol 133: 419-423, 1988
28. Van Der Laak JAWM, Westphal JR, Schalkwijk M: An improved procedure to quantify tumour vascularity using true color image analysis. Comparison with the manual hot-spot procedure in a human melanoma xenograft model. J Pathol 184:136-143, 1998
29. Vartanian RK, Weidner N: Correlation of intratumoral endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation in breast carcinoma. Am J Pathol 144:1188-1194, 1994
30. Weidner N, Semple JP, Welch WR: Tumour angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 324:1-8, 1991
31. Weidner N, Carroll JF, Blumenfeld W: Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 143:401-409, 1993
32. Weidner N: Tumoural vascularity as a prognostic factor in cancer patients: the evidence continues to grow. J Pathol 184:119-122, 1998