Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: The Tromsø Study

Journal of Internal Medicine

Volumn 260, Issue 1, 2006, Pages 53-61

  Iqbal, A ^a   Jorde, R ^b   Figenschau, Y ^a  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Cholesterol; Epidemiology; Lipid metabolism; Thyroid diseases; Triglycerides

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EVALUATION; FEMALE; HEALTH SURVEY; HUMAN; HYPOTHYROIDISM; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SAMPLE SIZE; SEX DIFFERENCE; THYROTROPIN BLOOD LEVEL; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; APOLIPOPROTEINS B; CHOLESTEROL; CHOLESTEROL, LDL; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; HYPOTHYROIDISM; LIPIDS; MALE; MIDDLE AGED; SEX FACTORS; THYROTROPIN; THYROXINE;

EID: 33745173079     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2006.01652.x     Document Type: Article

References (28)

1. Tunbridge WM Evered DC Hall R et al. Lipid profiles and cardiovascular disease in the Whickham area with particular reference to thyroid failure. Clin Endocrinol 1977 7: 495 508.
2. Pirich C Mullner M Sinzinger H. Prevalence and relevance of thyroid dysfunction in 1922 cholesterol screening participants. J Clin Epidemiol 2000 53: 623 9.
3. Imaizumi M Akahoshi M Ichimaru S et al. Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism. J Clin Endocrinol Metab 2004 89: 3365 70.
4. Lee WY Suh JY Rhee EJ Park JS Sung KC Kim SW. Plasma CRP, apolipoprotein A-1, apolipoprotein B and Lpa levels according to thyroid function status. Arch Med Res 2004 35: 540 5.
5. Canaris GJ Manowitz NR Mayor G Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000 160: 526 34.
6. Caraccio N Ferrannini E Monzani F. Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study. J Clin Endocrinol Metab 2002 87: 1533 8.
7. Meier C Staub JJ Roth CB et al. TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study). J Clin Endocrinol Metab 2001 86: 4860 6.
8. Monzani F Caraccio N Kozakowa M et al. Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study. J Clin Endocrinol Metab 2004 89: 2099 106.
9. Cooper DS Halpern R Wood LC Levin AA Ridgway EC. L-Thyroxine therapy in subclinical hypothyroidism. A double-blind, placebo-controlled trial. Ann Intern Med 1984 101: 18 24.
10. Kong WM Sheikh MH Lumb PJ et al. A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism. Am J Med 2002 112: 348 54.
11. Gullu S Sav H Kamel N. Effects of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism. Eur J Endocrinol 2005 152: 355 61.
12. Knudsen N Laurberg P Rasmussen LB et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 2005 90: 4019 24.
13. Jorde R Sundsfjord J Fitzgerald P Bonaa KH. Serum calcium and cardiovascular risk factors and diseases: the Tromsø study. Hypertension 1999 34: 484 90.
14. Jorde R Saleh F Figenschau Y Kamycheva E Haug E Sundsfjord J. Serum parathyroid hormone (PTH) levels in smokers and non-smokers. The fifth Tromso study. Eur J Endocrinol 2005 152: 39 45.
15. Jorde R Bønaa KH Sundsfjord J. Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromsø Study. Eur J Endocrinol 1999 141: 350 7.
16. Zulewski H Muller B Exer P Miserez AR Staub JJ. Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab 1997 82: 771 6.
17. Efstathiadou Z Bitsis S Milionis HJ et al. Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial Eur J Endocrinol 2001 145: 705 10.
18. Bindels AJ Westendorp RG Frolich M Seidell JC Blokstra A Smelt AH. The prevalence of subclinical hypothyroidism at different total plasma cholesterol levels in middle aged men and women: a need for case-finding Clin Endocrinol 1999 50: 217 20.
19. Kannel WB Castelli WP Gordon T McNamara PM. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Intern Med 1971 74: 1 12.
20. Walldius G Jungner I. Apolipoprotein B and apolipoprotein A-I: risk indicators of coronary heart disease and targets for lipid-modifying therapy. J Intern Med 2004 255: 188 205.
21. Yildirimkaya M Ozata M Yilmaz K Kilinc C Gundogan MA Kutluay T. Lipoprotein(a) concentration in subclinical hypothyroidism before and after levo-thyroxine therapy. Endocr J 1996 43: 731 6.
22. Bairaktari ET Tselepis AD Millionis HJ Elisaf MS. Lipoprotein (a) levels, apolipoprotein (a) phenotypes and thyroid autoimmunity. Eur J Endocrinol 1999 140: 474 6.
23. Tanis BC Westendorp GJ Smelt HM. Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies. Clin Endocrinol 1996 44: 643 9.
24. Danese MD Ladenson PW Meinert CL Powe NR. Clinical review 115: effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J Clin Endocrinol Metab 2000 85: 2993 3001.
25. Ineck BA Ng TM. Effects of subclinical hypothyroidism and its treatment on serum lipids. Ann Pharmacother 2003 37: 725 30.
26. McDermott MT Ridgway EC. Subclinical hypothyroidism is mild thyroid failure and should be treated. J Clin Endocrinol Metab 2001 86: 4585 90.
27. Biondi B Palmieri EA Lombardi G Fazio S. The importance of using strict inclusion criteria in subclinical hypothyroid studies. Am J Med 2003 114: 76.
28. Bjøro T Holmen J Kruger O et al. Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trøndelag (HUNT). Eur J Endocrinol 2000 143: 639 47.