Complete blood count, measures of iron status and inflammatory markers in inner-city African Americans with undiagnosed hepatitis C seropositivity

Clinica Chimica Acta

Volumn 411, Issue 9-10, 2010, Pages 653-656

  Ufearo, Hilary ^a   Kambal, Khalid ^a   Onojobi, Gladys O ^a   Nouraie, Mehdi ^a   Agbemabiese, Charles ^a   Diaz, Sharmin ^a   Aggarwal, Anita ^a   Aliyu, Zakari ^a   Taylor, Robert E ^a   Gordeuk, Victor R ^a  

^a HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

African American; CRP; HCV infection; Iron metabolism

Indexed keywords

C REACTIVE PROTEIN; HAPTOGLOBIN; IRON; TRANSFERRIN;

ADULT; AFRICAN AMERICAN; ALCOHOL CONSUMPTION; ARTICLE; BLOOD CELL COUNT; CHRONIC INFLAMMATION; CONTROLLED STUDY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FERRITIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HEPATITIS C; HUMAN; IRON BLOOD LEVEL; IRON INTAKE; IRON STORAGE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEROPREVALENCE; THROMBOCYTE COUNT; URBAN POPULATION;

AFRICAN AMERICANS; AGE FACTORS; ALANINE TRANSAMINASE; ALCOHOL DRINKING; ANTIBODIES; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; BLOOD CELL COUNT; BLOOD PROTEINS; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; DISTRICT OF COLUMBIA; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HEPATITIS C; HUMANS; INFLAMMATION; IRON; MALE; MIDDLE AGED; PREVALENCE; SERUM ALBUMIN; TRANSFERRIN; URBAN POPULATION;

HEPATITIS C VIRUS;

EID: 77950459114     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.01.028     Document Type: Article

References (31)

1. Kim W.R. The burden of hepatitis C in the United States. Hepatology 2002, 36:S30-S34.
2. Pearlman B.L. Hepatitis C virus infection in African Americans. Clin Infect Dis 2006, 42:82-91.
3. Pyrsopoulos N., Jeffers L. Hepatitis C in African Americans. J Clin Gastroenterol 2007, 41:185-193.
4. Alter M.J. Hepatitis C virus infection in the United States. J Hepatol 1999, 31(SUPPL 1):88-91.
5. Etienne A., Gayet S., Vidal F., Poullin P., Brunet C., Harle J.R., et al. Severe hemolytic anemia due to cold agglutinin complicating untreated chronic hepatitis C: efficacy and safety of anti-CD20 (rituximab) treatment. Am J Hematol 2004, 75:243-245.
6. McHutchison J.G., Dusheiko G., Shiffman M.L., Rodriguez-Torres M., Sigal S., Bourliere M., et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007, 357:2227-2236.
7. Bashour F.N., Teran J.C., Mullen K.D. Prevalence of peripheral blood cytopenias (hypersplenism) in patients with nonalcoholic chronic liver disease. Am J Gastroenterol 2000, 95:2936-2939.
8. Fujita N., Sugimoto R., Takeo M., Urawa N., Mifuji R., Tanaka H., et al. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007, 13:97-104.
9. Mengshol J.A., Golden-Mason L., Rosen H.R. Mechanisms of disease: HCV-induced liver injury. Nat Clin Pract Gastroenterol Hepatol 2007, 4:622-634.
10. Ostapowicz G., Watson K.J., Locarnini S.A., Desmond P.V. Role of alcohol in the progression of liver disease caused by hepatitis C virus infection. Hepatology 1998, 27:1730-1735.
11. Castellano-Higuera A., Gonzalez-Reimers E., Aleman-Valls M.R., Abreu-Gonzalez P., Santolaria-Fernandez F., De La Vega-Prieto M.J., et al. Cytokines and lipid peroxidation in alcoholics with chronic hepatitis C virus infection. Alcohol Alcohol 2008, 43:137-142.
12. Pepys M.B., Hirschfield G.M. C-reactive protein: a critical update. J Clin Invest 2003, 111:1805-1812.
13. Fleming D.J., Jacques P.F., Dallal G.E., Tucker K.L., Wilson P.W., Wood R.J. Dietary determinants of iron stores in a free-living elderly population: the Framingham Heart Study. Am J Clin Nutr 1998, 67:722-733.
14. Liu J.M., Hankinson S.E., Stampfer M.J., Rifai N., Willett W.C., Ma J. Body iron stores and their determinants in healthy postmenopausal US women. Am J Clin Nutr 2003, 78:1160-1167.
15. Milman N., Kirchhoff M. Relationship between serum ferritin, alcohol intake, and social status in 2235 Danish men and women. Ann Hematol 1996, 72:145-151.
16. Gordeuk V.R., Diaz S.F., Onojobi G.O., Debebe Z., Edossa A., Pantin J.M., et al. Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. Alcohol Clin Exp Res 2008, 32:1947-1953.
17. Stram D.O., Hankin J.H., Wilkens L.R., Pike M.C., Monroe K.R., Park S., et al. Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. Am J Epidemiol 2000, 151:358-370.
18. Gottschalk R., Wigand R., Dietrich C.F., Oremek G., Liebisch F., Hoelzer D., et al. Total iron-binding capacity and serum transferrin determination under the influence of several clinical conditions. Clin Chim Acta 2000, 293:127-138.
19. Ford C., Wells F.E., Rogers J.N. Assessment of iron status in association with excess alcohol consumption. Ann Clin Biochem 1995, 32(PART 6):527-531.
20. Weiss G., Goodnough L.T. Anemia of chronic disease. N Engl J Med 2005, 352:1011-1023.
21. Floris-Moore M., Howard A.A., Lo Y., Schoenbaum E.E., Arnsten J.H., Klein R.S. Hepatitis C infection is associated with lower lipids and high-sensitivity C-reactive protein in HIV-infected men. AIDS Patient Care STDS 2007, 21:479-491.
22. Reingold J., Wanke C., Kotler D., Lewis C., Tracy R., Heymsfield S., et al. Association of HIV infection and HIV/HCV coinfection with C-reactive protein levels: the fat redistribution and metabolic change in HIV infection (FRAM) study. J Acquir Immune Defic Syndr 2008, 48:142-148.
23. Malaguarnera M., Di Fazio I., Laurino A., Ferlito L., Romano M., Trovato B.A. Serum interleukin 6 concentrations in chronic hepatitis C patients before and after interferon-alpha treatment. Int J Clin Pharmacol Ther 1997, 35:385-388.
24. Malaguarnera M., Di Fazio I., Romeo M.A., Restuccia S., Laurino A., Trovato B.A. Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus. J Gastroenterol 1997, 32:211-215.
25. Machida K., Cheng K.T., Sung V.M., Levine A.M., Foung S., Lai M.M. Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol 2006, 80:866-874.
26. Migita K., Abiru S., Maeda Y., Daikoku M., Ohata K., Nakamura M., et al. Serum levels of interleukin-6 and its soluble receptors in patients with hepatitis C virus infection. Hum Immunol 2006, 67:27-32.
27. Gelderblom H.C., Nijhuis L.E., de Jong E.C., te Velde A.A., Pajkrt D., Reesink H.W., et al. Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile. Liver Int 2007, 27:944-953.
28. Zumrutdal A., Ozer B., Singan M., Micozkadioglu H., Sezer S., Ozdemir F.N., et al. Effect of anti-HCV positivity on markers of malnutrition and inflammation in hemodialysis patients. Ren Fail 2007, 29:85-90.
29. Villacres M.C., Literat O., DeGiacomo M., Du W., Frederick T., Kovacs A. Defective response to Toll-like receptor 3 and 4 ligands by activated monocytes in chronic hepatitis C virus infection. J Viral Hepat 2008, 15:137-144.
30. Andrews N.C. Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest 2004, 113:1251-1253.
31. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.