Breviscapine-induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity

Phytotherapy Research

Volumn 24, Issue 8, 2010, Pages 1188-1194

  Wu, Yulin ^a   Fan, Qianqian ^a   Lu, Na ^a   Tao, Lei ^a   Gao, Yuan ^a   Qi, Qi ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bax; Bcl 2; Breviscapine; Human hepatocellular carcinoma cell

Indexed keywords

BREVISCAPINE; CASPASE 3; PROTEIN BAX; PROTEIN BCL 2; ANTINEOPLASTIC AGENT; CASP3 PROTEIN, HUMAN; FLAVONOID; HERBACEOUS AGENT; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; DRUG EFFECTS; FLOW CYTOMETRY; HEPG2 CELL LINE; METABOLISM;

BREVISCAPUS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; DRUGS, CHINESE HERBAL; FLAVONOIDS; FLOW CYTOMETRY; HEP G2 CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 77950357965     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3002     Document Type: Article

References (27)

1. Ashe PC, Berry MD. 2003. Apoptotic signaling cascades. Prog Neuropsychopharmacol Biol Psychiatry 27: 199-214.
2. Cory S, Huang DC, Adams JM. 2003. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590-8607. (Pubitemid 38028528)
3. Ghobrial IM, Witzig TE, Adjei AA. 2005. Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55: 178-194. (Pubitemid 40826487)
4. Green DR. 2000. Apoptotic pathways: paper wraps stone blunts scissors. Cell 102: 1-4.
5. Harada H, Grant S. 2003. Apoptosis regulators. Rev Clin Exp Hematol 7: 117-138.
6. Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407: 770-776.
7. Hu Y, Yang Y, You QD, Liu W, Gu HY, Zhao L, Zhang K, Wang W, Wang XT, Guo QL. 2006. Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. Biochem Biophys Res Commun 351: 521-527. (Pubitemid 44666718)
8. Kerr JF, Winterford CM, Harmon BV. 1994. Apoptosis. Its significance in cancer and cancer therapy. Cancer 73: 2013-2026. (Pubitemid 24107952)
9. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136. (Pubitemid 27097313)
10. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347. (Pubitemid 24300618)
11. Manthey JA, Grohmann K, Guthrie N. 2001. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem 8: 135-153. (Pubitemid 32421562)
12. Marder M, Paladini AC. 2002. GABA(A)-receptor ligands of flavonoid structure. Curr Top Med Chem 2: 853-867.
13. Middleton E Jr, Kandaswami C, Theoharides TC. 2000. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52: 673-751.
14. Qin ZH, Wang Y, Kikly KK, Sapp E, Kegel KB, Aronin N, DiFiglia M. 2001. Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation. J Biol Chem 276: 8079-8086. (Pubitemid 37385611)
15. Shi SG, Shao SQ, Chen KN. 1998. Study of therapeutic effects of Erigeron breviscapus preparation on cerebral ischemia-perfusion damage in rats. Acta Acad Med Militaris Tertiae 20: 320-322.
16. Shuai J, Dong WW. 1998. Experimental research of PKC inhibitor. Erigeron breviscapus on the ischemic/reperfusional brain injury. Chin Pharmacol Bull 14: 75-77.
17. Stennicke HR, Salvesen GS. 1998. Properties of the caspases. Biochim Biophys Acta 1387: 17-31.
18. Tamm I, Schriever F, Dorken B. 2001. Apoptosis: implications of basic research for clinical oncology. Lancet Oncol 2: 33-42. (Pubitemid 33585915)
19. van Delft MF, Huang DC. 2006. How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res 16: 203-213. (Pubitemid 43247978)
20. Wang X. 2001. The expanding role of mitochondria in apoptosis. Genes Dev 15: 2922-2933.
21. Wang Z. 2004. Roles of K+ channels in regulating tumour cell proliferation and apoptosis. Pflugers Arch 448: 274-286. (Pubitemid 40895596)
22. Wonderlin WF, Strobl JS. 1996. Potassium channels, proliferation and G1 progression. J Membr Biol 154: 91-107.
23. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132. (Pubitemid 27097312)
24. Yu SP, Choi DW. 2000. Ions, cell volume, and apoptosis. Proc Natl Acad Sci USA 97: 9360-9362.
25. Zhang J, Li XS, Zhnag WD. 2002. The advance in studies on chemical component and pharmacology of Erigeron breviscapus. J Pharm Pract 20: 103-107.
26. Zhou QS, Zhao YM, Bai X, Li PX, Ruan CG. 1992. Effect of new-breviscapine on fibrinolysis and anticoagulation of human vascular endothelial cells. Zhongguo Yao Li Xue Bao 13: 239-242.
27. Zornig M, Hueber A, Baum W, Evan G. 2001. Apoptosis regulators and their role in tumorigenesis. Biochim Biophys Acta 1551: F1-37.