Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats

British Journal of Nutrition

Volumn 103, Issue 6, 2010, Pages 869-878

  Martins, Susana V ^a   Lopes, Paula A ^a   Alfaia, Cristina M ^a   Rodrigues, Pedro O ^b   Alves, Susana P ^c,d   Pinto, Rui M A ^e   Castro, Matilde F ^e   Bessa, Rui J B ^a,c   Prates, José A M ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b NOVA MEDICAL SCHOOL   (Portugal)

^c L INIA   (Portugal)

^d UNIVERSITY OF PORTO   (Portugal)

^e RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Adipokines; Conjugated linoleic acid; Fatty acids; Obese Zucker rats; Saturated diets

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; C REACTIVE PROTEIN; CONJUGATED LINOLEIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOUNSATURATED FATTY ACID; PALM OIL; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; TUMOR NECROSIS FACTOR ALPHA; CHOLESTEROL; EDIBLE OIL; FATTY ACID; LIPID; TRANS 10,CIS 12 CONJUGATED LINOLEIC ACID; TRANS-10,CIS-12-CONJUGATED LINOLEIC ACID; VEGETABLE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; EPIDIDYMIS FAT; INFLAMMATION; INSULIN RESISTANCE; LIPID COMPOSITION; LIPID LIVER LEVEL; LIPID STORAGE; LIVER WEIGHT; MALE; NONHUMAN; OBESITY; PRINCIPAL COMPONENT ANALYSIS; RAT; RETROPERITONEAL FAT; ADIPOSE TISSUE; ANIMAL; BLOOD; BODY COMPOSITION; CHEMISTRY; EPIDIDYMIS; FAT INTAKE; HISTOLOGY; INTRAABDOMINAL FAT; LIVER; METABOLISM; ORGAN SIZE; SHEEP; ZUCKER RAT;

ANIMALIA; OVIS; RATTUS;

ADIPOKINES; ADIPOSE TISSUE; ANIMALS; BODY COMPOSITION; CHOLESTEROL; DIETARY FATS; DIETARY FATS, UNSATURATED; EPIDIDYMIS; FATTY ACIDS; INTRA-ABDOMINAL FAT; LINOLEIC ACIDS, CONJUGATED; LIPIDS; LIVER; MALE; OBESITY; ORGAN SIZE; PLANT OILS; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, ZUCKER; SHEEP;

EID: 77950355294     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S000711450999256X     Document Type: Article

References (41)

1. Murdolo G & Smith U (2006) The dysregulated adipose tissue: a connecting link between insulin resistance, type 2 diabetes mellitus and atherosclerosis. Nutr Metab Cardiovasc Dis 16, S35-S38.
2. Fain JN (2006) Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74, 443-477.
3. Wang P, Mariman E, Renes J, et al. (2008) The secretory function of adipocytes in the physiology of white adipose tissue. J Cell Physiol 216, 3-13.
4. Vendrell J, Broch M, Vilarrasa N, et al. (2004) Resistin, adiponectin, ghrelin, leptin and proinflammatory cytokines: relationships in obesity. Obes Res 12, 962-971.
5. Dolinková M, Dostálová I, Lacinová Z, et al. (2008) The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Mol Cell Endocrinol 291, 63-70.
6. Trayhurn P (2005) Adipose tissue in obesity-an inflammatory issue. Endocrinology 146, 1003-1005.
7. Yamasaki M, Ikeda A, Oji M, et al. (2003) Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. Nutrition 19, 30-35.
8. Martins SV, Lopes PA, Alfaia CM, et al. (2007) Contents of conjugated linoleic acid isomers in ruminant-derived foods and estimation of their contribution to daily intake in Portugal. Br J Nutr 98, 1206-1213.
9. Wang Y, Nagao K, Inoue N, et al. (2006) Isomer-specific anti-obese and hypolipidemic properties of conjugated linoleic acid in obese OLETF rats. Biosci Biotechnol Biochem 70, 355-362.
10. Park Y, Albright KJ, Storkson JM, et al. (2007) Conjugated linoleic acid (CLA) prevents body fat accumulation and weight gain in an animal model. J Food Sci 72, S612-S617.
11. Wendel AA, Purushotham A, Liu L-F, et al. (2008) Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J Lipid Res 49, 98-106.
12. Halade GV, Rahman M & Fernandes G (2009) Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57BL/6J mice. J Nutr Biochem (Epublication ahead of print version 6 May 2009).
13. Ukropec J, Reseland JE, Gasperikova D, et al. (2003) The hypo-triglyceridemic effect of dietary n-3 FA is associated with increased b-oxidation and reduced leptin expression. Lipids 38, 1023-1029.
14. Kim K, Kim HY, Son EJ, et al. (2009) Oleic acid inhibits hepatic insulin signaling through deregulation of STAT3 activation and C/EBPalpha expression. Cell Signal 21, 1269-1276.
15. Montague CT, Farooqi IS, Whitehead JP, et al. (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908.
16. Kasiske BL, O'Donnell MP & Keane WF (1992) The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 19, Suppl. I, I110-I115.
17. Akahoshi A, Koba K, Enmoto R, et al. (2005) Combined effects of dietary protein type and fat level on the body fat-reducing activity of conjugated linoleic acid (CLA) in rats. Biosci Biotechnol Biochem 69, 2409-2415.
18. Hu FB, Manson JE & Willet WC (2001) Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr 20, 5-19.
19. Jerónimo E, Alves SP, Prates JAM, et al. (2009) Effect of dietary replacement of sunflower oil with linseed oil on intramuscular fatty acids of lamb meat. Meat Sci 83, 499-505.
20. Friedewald WT, Levy RI & Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499-502.
21. Covaci A, Voorspoels S, Thomsen C, et al. (2006) Evaluation of total lipids using enzymatic methods for the normalization of persistent organic pollutant levels in serum. Sci Total Environ 366, 361-366.
22. Matthews DR, Hosker JP, Rudenski AS, et al. (1985) Homeo-stasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419.
23. Fritshe J, Fritsche S, Solomon MB, et al. (2000) Quantitative determination of conjugated linoleic acid isomers in beef fat. Eur J Lipid Sci Technol 102, 667-672.
24. Christie WW, Sébédio JL, Juanéda P, et al. (2001) A practical guide to the analysis of conjugated inoleic acid (CLA). Inform 12, 147-152.
25. Raes K, Haak L, Balcaen A, et al. (2004) Effect of linseed feeding at similar linoleic acid levels on the fatty acid composition of double-muscled Belgian Blue young bulls. Meat Sci 66, 307-315.
26. Nagao K, Inoue N, Wang Y-M, et al. (2005) Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats. J Nutr 135, 9-13.
27. Noto A, Zahradka P, Yurkova N, et al. (2006) Conjugated lino-leic acid reduces hepatic steatosis, improves liver function, and favorably modifies lipid metabolism in obese insulin-resistant rats. Lipids 41, 179-188.
28. Gudbrandsen O, Rodriguez E, Wergedahl H, et al. (2009) Trans-10,cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats. Br J Nutr 102, 803-815.
29. Sisk MB, Hausman DB, Martins RJ, et al. (2001) Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. J Nutr 131, 1668-1674.
30. Noto A, Zahradka P, Yurkova N, et al. (2007) Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rat. Metabolism 56, 1601-1611.
31. Alessi MC, Bastelica D, Mavri A, et al. (2003) Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation. Arterioscler Thromb Vasc Biol 23, 1262-1268.
32. Munday JS, Thompson KG & James KA (1999) Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Br J Nutr 81, 251-255.
33. Kelley DS, Bartolini GL, Newman JW, et al. (2006) Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10,c12 and c9,t11-conjugated linoleic acid. Prostag Leukotr Ess 74, 271-282.
34. Park Y, Storkson J, Ntambi JM, et al. (2000) Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivates. Biochim Biophys Acta 1486, 285-292.
35. Byberg L, Smedman A, Vessby B, et al. (2001) Plasminogen activator inhibitor-1 and relations to fatty acid composition in the diet and in serum cholesterol esters. Arterioscler Thromb Vasc Biol 21, 2086-2092.
36. Roche HM, Noone E, Sewter C, et al. (2002) Isomer-dependent metabolic effects of conjugated linoleic acid-insights from molecular markers sterol regulatory element-binding protein-1c and LXRa. Diabetes 51, 2037-2044.
37. Ryder JW, Portocarrero CP, Song XM, et al. (2001) Isomer-specific antidiabetic properties of conjugated linoleic acid-improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes 50, 1149-1157.
38. Kennedy A, Martinez K, Chuang C-C, et al. (2009) Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications. J Nutr 139, 1-4.
39. Petersson H, Lind L, Hulthe J, et al. (2009) Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population. Atherosclerosis 203, 298-303.
40. Corl BA, Barbano DM & Bauman DE (2003) Cis-9,trans-11 CLA derived endogenously from trans-11 18: 1 reduces cancer risk in rats. J Nutr 133, 2893-2900.
41. Roy A, Chardigny JM, Bauchart D, et al. (2007) Butters rich either in trans-10-C18:1 or in trans-11-C18:1 plus cis-9,trans-11 CLA differentially affect plasma lipids and aortic fatty streak in experimental atherosclerosis in rabbits. Animal 1, 467-476.