Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats

Journal of Nutrition

Volumn 135, Issue 1, 2005, Pages 9-13

  Nagao, Koji ^a   Inoue, Nao ^a   Wang, Yu Ming ^a   Shirouchi, Bungo ^a   Yanagita, Teruyoshi ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

Adiponectin; Conjugated linoleic acid; Nonalcoholic fatty liver disease; Tumor necrosis factor ; Zucker (fa fa) rats

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE; CONJUGATED LINOLEIC ACID; LACTATE DEHYDROGENASE; LINOLEIC ACID; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID OXIDATION; FEEDING; GENE EXPRESSION; HEPATOMEGALY; HYPERINSULINEMIA; INSULIN SENSITIVITY; LIPID STORAGE; LIPOPROTEIN SECRETION; LIVER INJURY; LIVER PROTECTION; LIVER WEIGHT; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; RAT STRAIN;

ANIMALIA;

EID: 11844291384     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.1.9     Document Type: Article

References (46)

1. Harrison, S. A. & Diehl, A. M. (2002) Fat and the liver - a molecular overview. Semin. Gastrointest. Dis. 13: 3-16.
2. Youssef, W. & McCullough, A. J. (2002) Diabetes mellitus, obesity, and hepatic steatosis. Semin. Gastrointest. Dis. 13: 17-30.
3. Fong, D. G., Nehra, V., Lindor, K. D. & Buchman, A. L. (2000) Metabolic and nutritional considerations in nonalcoholic fatty liver. Hepatology 32: 3-10.
4. Chua, S. C., Chung, W. K., Wu-Peng, S., Zhang, Y. Y., Liu, S., Tartaglia, L. A. & Leibel, R. L. (1996) Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science (Washington, DC) 271: 994-996.
5. Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. J. & Hess, J. F. (1996) Leptin receptor missense mutation in the fatty Zucker rat. Nat. Genet. 13: 18-19.
6. Stepp, D. W. & Frisbee, J. C. (2002) Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats. Am. J. Physiol. 282: H816-H820.
7. Ha, Y. L., Grimm, N. K. & Pariza, M. W. (1989) Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J. Agric. Food Chem. 37: 75-81.
8. Chin, S. F., Liu, W., Storkson, J. M., Ha, Y. L. & Pariza, M. W. (1992) Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J. Food Comp. Anal. 5: 185-197.
9. Ip, C., Scimeca, J. A. & Thompson, H. J. (1994) Conjugated linoleic acid, a powerful anticarcinogen from animal fat sources. Cancer 74: 1050-1054.
10. Lee, K. N., Kritchevsky, D. & Pariza, M. W. (1994) Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108: 19-25.
11. Nagao, K., Wang, Y. M., Inoue, N., Han, S. Y., Buang, Y., Noda, T., Kouda, N., Okamatsu, H. & Yanagita, T. (2003) The 10trans,12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. Nutrition 19: 652-656.
12. Houseknecht, K. L., Vanden Heuvel, J. P., Moya-Camarena, S. Y., Portocarrero, C. P., Peck, L. W., Nickel, K. P. & Belury, M. A. (1998) Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem. Biophys. Res. Commun. 244: 678-682.
13. Smedman, A. & Vessby, B. (2001) Conjugated linoleic acid supplementation in human metabolic effects. Lipids 36: 773-781.
14. Nagao, K., Inoue, N., Wang, Y. M., Buang, Y., Hirata, J., Nagao, T., Shimada, Y., Matsui, T. & Yanagita, T. (2003) The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima Fatty rats. Biochem. Biophys. Res. Commun. 306: 134-138.
15. Nagao, K., Inoue, N., Wang, Y. M. & Yanagita, T. (2003) Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats. Biochem. Biophys. Res. Commun. 310: 562-566.
16. Clement, L., Pirier, H., Niot, I., Bocher, V., Guerre-Millo, M., Krief, S., Staels, B. & Besnard, P. (2002) Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J. Lipid Res. 43: 1400-1409.
17. Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H. J., Tnage, T., Okuyama, H., Kasai, M., Ikemoto, S. & Ezaki, O. (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49: 1534-1542.
18. Berven, G., Bye, A., Hals, O., Blankson, H., Fagertun, H., Thom, E., Wadstein, J. & Gudmundsen, O. (2000) Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur. J. Lipid Sci. Technol. 102: 455-462.
19. Kreider, R. B., Ferreira, M. P., Greenwood, M., Wilson, M. & Almada, A. L. (2002) Effect of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J. Strength Cond. Res. 16: 325-334.
20. Pariza, M. W. (2004) Perspective on the safety and effectiveness of conjugated linoleic acid. Am. J. Clin. Nutr. 79: 1132S-1136S.
21. Tsuboyama-Kasaoka, N., Miyazaki, H., Kasaoka, S. & Ezaki, O. (2003) Increasing the amount of fat in a conjugated linoleic acid-supplemented diet reduces lipodystrophy in mice. J. Nutr. 133: 1793-1799.
22. American Institute of Nutrition (1977) Report of the American Institute of Nutrition of ad hoc committee on standards for nutritional studies. J. Nutr. 107: 1340-1348.
23. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
24. Markwell, M.A.K., McGroarty, E. J., Bieber, L. L & Tolbert, N. E. (1973) The subcellular distribution of carnitine acyltransferases in mammalian liver and kidney. J. Biol. Chem. 248: 3433-3440.
25. Folch, J., Lee, M. & Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
26. Fletcher, M.J.A (1968) Colorimetric method for estimation of serum triglycerides. Clin. Chem. Acta 22: 393-397.
27. Sakono, M., Miyanaga, F., Kawahara, S., Yamauchi, K., Fukuda, N., Watanabe, K., Iwata, T. & Sugano, M. (1999) Dietary conjugated linoleic acid reciprocally modifies ketogenesis and lipid secretion by the rat liver. Lipids 34: 997-1000.
28. Rahman, S. M., Wang, Y. M., Han, S. Y., Cha, J. Y., Fukuda, N., Yotsumoto, H. & Yanagita, T. (2001) Effects of short-term administration of conjugated linoleic acid on lipid metabolism in white and brown adipose tissues of starved/refed Otsuka Long-Evans Tokushima Fatty rats. Food Res. Int. 34: 515-520.
29. Rahman, S. M., Wang, Y. M., Yotsumoto, H., Cha, J. Y., Han, S. Y., Inoue, S. & Yanagita, T. (2001) Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. Nutrition 17: 385-390.
30. Wang, Y. M., Rahman, S. M., Nagao, K., Arao, K., Inoue, N. & Yanagita, T. (2003) Comparison of the effects of triacylglycerol-CLA and free fatty acid-CLA on hepatic lipid metabolism in OLETF obese rats. J. Oleo Sci. 52: 121-128.
31. Zammit, V. A., Waterman, I. J., Topping, D. & McKay, G. (2001) Insulin stimulation of hepatic triacylglycerol secretion and the etiology of insulin resistance. J. Nutr. 131: 2074-2077.
32. Marceau, P., Biron, S., Hould, F. S., Marceau, S., Simard, S., Thung, S. N. & Kral, J. G. (1999) Liver pathology and the metabolic Syndrome X in severe obesity. J. Clin. Endocrinol. Metab. 84: 1513-1517.
33. Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G. & Melchionda, N. (2001) Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50: 1844-1850.
34. Marchesini, G., Bugianesi, E., Forlani, G., Cerrelli, F., Lenzi, M., Manini, R., Natale, S., Vanni, E., Villanova, N., Melchionda, N. & Rizzetto, M. (2003) Non-alcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37: 917-923.
35. Ryder, J. W., Portocarrero, C. P., Song, X. M., Cui, L., Yu, M., Combatsiaris, T., Galuska, D., Bauman, D. E., Barbano, D. M., Charron, M. J., Zierath, J. R. & Houseknecht, K. L. (2001) Isomer specific antidiabetic properties of conjugated linoleic acid. Diabetes 50: 1149-1157.
36. Henriksen, E. J., Teachey, M. K., Taylor, Z. C., Jacob, S., Ptock, A., Kramer, K. & Hsselwander, O. (2003) Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. Am. J. Physiol. 285: E98-E105.
37. Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T. & Matsuzawa, Y. (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257: 79-83.
38. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y. Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M. L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P. & Kadowaki, T. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7: 941-946.
39. Berg, A. H., Combs, T. P., Du, X., Brownlee, M. & Sherer, P. E. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7: 947-953.
40. Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C. & Matsuzawa, Y. (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50: 1126-1133.
41. Xu, A., Wang, Y., Keshaw, H., Xu, L. Y., Lam, K. S. L. & Cooper, G. J. S. (2003) The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver disease in mice. J. Clin. Investig. 112: 91-100.
42. Lopez-Bermejo, A., Botas, P., Funahashi, T., Delgado, E., Kihara, S., Ricart, W. & Fernandez-Real, J. M. (2004) Adiponectin, hepatocellular dysfunction and insulin sensitivity. Clin. Endocrinol. 60: 256-263.
43. Bajaj, M., Suraamornkul, S., Piper, P., Hardies, L. J., Glass, L., Cersosimo, E., Pratipanawatr, T., Miyazaki, Y. & Defronzo, R. A. (2004) Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type2 diabetes patients. J. Clin. Endocrinol. Metab. 89: 200-206.
44. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki, T., Uchida, S., Takekawa, S., Waki, H., Tsuno, N. H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R. & Kadowaki, T. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (Lond.) 423: 762-769.
45. Day, C. P. & James, O. F. (1998) Steatohepatitis: a tale of two "hits"? Gastroenterology 114: 842-845.
46. Koteish, A. (2002) Animal models of Steatohepatitis. Best Pract. Res. Clin. Gastroenterol. 16: 679-690.