Bioavailability of 2-O-α-d-glucopyranosyl-l-ascorbic acid as ascorbic acid in healthy humans

Nutrition

Volumn 25, Issue 6, 2009, Pages 686-691

  Nakamura, Sadako ^a   Oku, Tsuneyuki ^a  

^a UNIVERSITY OF NAGASAKI   (Japan)

Author keywords

2 O d glucopyranosyl L ascorbic acid; Ascorbic acid; Bioavailability in humans; Intestinal maltase

Indexed keywords

2 O ALPHA DEXTRO GLUCOPYRANOSYL LEVO ASCORBIC ACID; ALPHA GLUCOSIDASE; ASCORBIC ACID; GLYCOSIDE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIOAVAILABILITY; BODY MASS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; RAT; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

ALPHA-GLUCOSIDASES; ANIMALS; AREA UNDER CURVE; ASCORBIC ACID; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; HYDROLYSIS; INTESTINAL MUCOSA; RATS; SPECIES SPECIFICITY; YOUNG ADULT;

RATTUS;

EID: 67349139599     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2008.11.031     Document Type: Article

References (20)

1. Mandai T., Yoneyama M., Sasaki S., Muto N., and Yamamoto I. The crystal structure and physicochemical properties of L-ascorbic acid 2-glucoside. Carbohydr Res 232 (1992) 197-205
2. Gregory III J.F. Nutritional properties and significance of vitamin glycosides. Annu Rev Nutr 18 (1998) 277-296
3. Takebayashi J., Tai A., Gohda E., and Yamamoto I. Characterization of the radical-scavenging reaction of 2-O-substituted ascorbic acid derivatives, AA-2G, AA-2P, and AA-2S: a kinetic and stoichiometric study. Biol Pharm Bull 29 (2006) 766-771
4. Muto N., Ban Y., Akiba M., and Yamamoto I. Evidence for the in vivo formation of ascorbic acid 2-O-α-glucoside in guinea pigs and rats. Biochem Pharmacol 42 (1991) 625-631
5. Wakamiya H., Suzuki E., Yamamoto I., Akiba M., and Arakawa N. In situ intestinal absorption of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid in guinea pigs. J Nutr Sci Vitaminol 41 (1995) 265-272
6. Yamamoto I., Suga S., Mitoh Y., Tanaka M., and Muto N. Antiscorbutic activity of L-ascorbic acid 2-glucoside and its availability as a vitamin C supplement in normal rats and guinea pigs. J Pharmacobiodyn 13 (1990) 688-695
7. Muto N., Terasawa K., and Yamamoto I. Evaluation of ascorbic acid 2-O-α-glucoside as vitamin C source: mode of intestinal hydrolysis and absorption following oral administration. Int J Vitam Nutr Res 62 (1992) 318-323
8. Kumano Y., Sakamoto T., Egawa M., Iwai I., Tanaka M., and Yamamoto I. In vitro and in vivo prolonged biological activities of novel vitamin C derivative, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), in cosmetic fields. J Nutr Sci Vitaminol 44 (1998) 345-359
9. Yamamoto I., Muto N., Murakami K., and Akiyama J. Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid. J Nutr 122 (1992) 871-877
10. Hodges R.E., Hood J., Canham J.E., Saubelich H.E., and Baker E.M. Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr 24 (1971) 432-443
11. Bezerra F.S., Valenca S.S., Lanzetti M., Pimenta W.A., Castro P., and Koatz V.L.G. α-Tocopherol and ascorbic acid supplementation reduced acute lung inflammatory response by cigarette smoke in mouse. Nutrition 22 (2006) 1192-1201
12. Gey K.F. Vitamins E plus C and interacting conutrients required for optimal health. A critical and constructive review of epidemiology and supplementation data regarding cardiovascular disease and cancer. Biofactors 7 (1998) 113-174
13. Dahlqvist A. Method of assay of intestinal disaccharidases. Anal Biochem 7 (1964) 18-25
14. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72 (1976) 248-258
15. Brubacher D., Moser U., and Jordan P. Vitamin C concentrations in plasma as a function of intake: meta-analysis. Int J Vitam Nutr Res 70 (2000) 226-237
16. Blanchard J., Tozer T.N., and Rowland M. Pharmacokinetic perspectives on megadoses of ascorbic acid. Am J Clin Nutr 66 (1997) 1165-1171
17. Cameron E., and Campbell A. The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer. Chem Biol Interact 9 (1974) 285-315
18. Kallner A.B., Hartmann D., and Hornig D.H. On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers. Am J Clin Nutr 34 (1981) 1347-1355
19. Li Y., and Schellhorn H.E. New developments and novel therapeutic perspectives for vitamin C. J Nutr 137 (2007) 2171-2184
20. Ataka S., Tanaka M., Nozaki S., Mizuma H., Mizuno K., Tahara T., et al. Effects of applephenon and ascorbic acid on physical fatigue. Nutrition 23 (2007) 419-423