Spotlights on advances in mycotoxin research

Applied Microbiology and Biotechnology

Volumn 87, Issue 1, 2010, Pages 1-7

  Bohnert, Markus ^a   Wackler, Barbara ^a   Hoffmeister, Dirk ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Ascomycetes; Basidiomycetes; Biosynthesis; Genomics; Mycotoxin; Natural products

Indexed keywords

BIOSYNTHETIC GENE; FILAMENTOUS FUNGI; GENOMICS; NATURAL PRODUCTS; REGULATORY MECHANISM; SECONDARY METABOLISM; SECONDARY METABOLITES; TRANSCRIPTOMICS;

BIOCHEMISTRY; BIOSYNTHESIS; GENE EXPRESSION; METABOLISM; METABOLITES;

FUNGI;

AFLATOXIN B1; ALPHA AMANITIN; FUMONISIN B1; GLIOTOXIN; MYCOTOXIN; SIRODESMIN PL; STERIGMATOCYSTIN; UNCLASSIFIED DRUG; VOMITOXIN; ZEARALENONE;

BIOACTIVITY; BIOCHEMISTRY; FUNGUS; GENE EXPRESSION; GENOMICS; METABOLISM; METABOLITE; TOXIN;

CHEMICAL STRUCTURE; FUNGAL METABOLISM; GENE EXPRESSION; GENOMICS; NONHUMAN; SHORT SURVEY; TRANSCRIPTOMICS; BIOSYNTHESIS; FUNGUS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RESEARCH; TRENDS;

FUNGI; GENE EXPRESSION REGULATION, FUNGAL; GENOMICS; MYCOTOXINS; RESEARCH;

ASCOMYCOTA; BASIDIOMYCOTA; FUNGI;

EID: 77950310790     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2565-8     Document Type: Short Survey

References (46)

1. A Atoui D Bao N Kaur WS Grayburn AM Calvo 2008 Aspergillus nidulans natural product biosynthesis is regulated by MpkB, a putative pheromone response mitogen-activated protein kinase Appl Environ Microbiol 74 3596 3600 10.1128/AEM.02842-07 1:CAS:528:DC%2BD1cXntFartr0%3D (Pubitemid 351812815)
2. CJ Balibar CT Walsh 2006 GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin Biochemistry 45 15029 15038 10.1021/bi061845b 1:CAS:528: DC%2BD28Xht1Wmtr%2FO (Pubitemid 44937015)
3. CJ Balibar AR Howard-Jones CT Walsh 2007 Terrequinone A biosynthesis through l-tryptophan oxidation, dimerization and bisprenylation Nat Chem Biol 3 584 592 10.1038/nchembio.2007.20 1:CAS:528:DC%2BD2sXpt1ersL0%3D (Pubitemid 47294397)
4. Ö Bayram S Krappmann M Ni JW Bok K Helmstaedt O Valerius S Braus-Stromeyer NJ Kwon NP Keller JH Yu GH Braus 2008 VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism Science 320 1504 1506 10.1126/science.1155888 1:CAS:528:DC%2BD1cXntVWqsro%3D (Pubitemid 351929431)
5. S Bergmann J Schümann K Scherlach C Lange AA Brakhage C Hertweck 2007 Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans Nat Chem Biol 3 213 217 10.1038/nchembio869 1:CAS:528: DC%2BD2sXjtFKnsrg%3D (Pubitemid 46440540)
6. JW Bok NP Keller 2004 LaeA, a regulator of secondary metabolism in Aspergillus spp Eukaryot Cell 3 527 535 10.1128/EC.3.2.527-535.2004 1:CAS:528:DC%2BD2cXjtlKqs7s%3D (Pubitemid 38497990)
7. JW Bok SA Balajee KA Marr D Andes KF Nielsen JC Frisvad NP Keller 2005 LaeA, a regulator of morphogenetic fungal virulence factors Eukaryot Cell 4 1574 1582 10.1128/EC.4.9.1574-1582.2005 1:CAS:528:DC%2BD2MXhtV2hu7rF (Pubitemid 41339112)
8. JW Bok D Hoffmeister LA Maggio-Hall R Murillo JD Glasner NP Keller 2006 Genomic mining for Aspergillus natural products Chem Biol 13 31 37 10.1016/j.chembiol.2005.10.008 1:CAS:528:DC%2BD28XmsV2ktw%3D%3D (Pubitemid 43099922)
9. JW Bok D Noordermeer SP Kale NP Keller 2006 Secondary metabolic gene cluster silencing in Aspergillus nidulans Mol Microbiol 61 1636 1645 10.1111/j.1365-2958.2006.05330.x 1:CAS:528:DC%2BD28XhtFensbnK (Pubitemid 44359389)
10. JW Bok YM Chiang E Szewczyk Y Reyes-Dominguez AD Davidson JF Sanchez HC Lo K Watanabe J Strauss BR Oakley CC Wang NP Keller 2009 Chromatin-level regulation of biosynthetic gene clusters Nat Chem Biol 5 462 464 10.1038/nchembio.177 1:CAS:528:DC%2BD1MXmtVOrtrk%3D
11. S Bouhired M Weber A Kempf-Sontag NP Keller D Hoffmeister 2007 Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA Fungal Genet Biol 44 1134 1145 10.1016/j.fgb.2006.12.010 1:CAS:528:DC%2BD2sXhtFKhsLvI (Pubitemid 47532762)
12. DW Brown JH Yu HS Kelkar M Fernandes TC Nesbitt NP Keller TH Adams TJ Leonard 1996 Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans Proc Natl Acad Sci USA 93 1418 1422 10.1073/pnas.93.4.1418 1:CAS:528:DyaK28Xht1ens7w%3D (Pubitemid 26075137)
13. YM Chiang KH Lee JF Sanchez NP Keller CC Wang 2009 Unlocking fungal cryptic natural products Nat Prod Commun 4 1505 1510 1:CAS:528: DC%2BD1MXhsVCjsLfK
14. JJ Coleman SD Rounsley M Rodriguez-Carres A Kuo CC Wasmann J Grimwood J Schmutz M Taga GJ White S Zhou DC Schwartz M Freitag LJ Ma EG Danchin B Henrissat PM Coutinho DR Nelson D Straney CA Napoli BM Barker M Gribskov M Rep S Kroken I Molnár C Rensing JC Kennell J Zamora ML Farman EU Selker A Salamov H Shapiro J Pangilinan E Lindquist C Lamers IV Grigoriev DM Geiser SF Covert E Temporini HD Vanetten 2009 The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion PLoS Genet 5 e1000618 10.1371/journal.pgen.1000618
15. RA Cramer Jr MP Gamcsik RM Brooking LK Najvar WR Kirkpatrick TF Patterson CJ Balibar JR Graybill JR Perfect SN Abraham WJ Steinbach 2006 Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production Eukaryot Cell 5 972 980 10.1128/EC.00049-06 1:CAS:528: DC%2BD28XmtVajurs%3D (Pubitemid 43895027)
16. RA Cramer Jr JE Stajich Y Yamanaka FS Dietrich WJ Steinbach JR Perfect 2006 Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus Gene 383 24 32 10.1016/j.gene.2006.07.008 1:CAS:528: DC%2BD28XhtFSgsr7L (Pubitemid 44584582)
17. AE Desjardins 2009 From yellow rain to green wheat: 25 years of trichothecene biosynthesis research J Agric Food Chem 57 4478 4484 10.1021/jf9003847 1:CAS:528:DC%2BD1MXkvVGgsrc%3D
18. CE Elliott DM Gardiner G Thomas A Cozijnsen AV De Wouw BJ Howlett 2007 Production of the toxin sirodesmin PL by Leptosphaeria maculans during infection of Brassica napus Mol Plant Pathol 8 791 802 10.1111/j.1364-3703.2007.00433.x 1:CAS:528:DC%2BD2sXhtlGgsL7M (Pubitemid 47568900)
19. EM Fox BJ Howlett 2008 Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi Mycol Res 112 162 169 10.1016/j.mycres.2007.08.017 1:CAS:528:DC%2BD1cXlsFOhsLw%3D
20. I Gaffoor F Trail 2006 Characterization of two polyketide synthase genes involved in zearalenone biosynthesis in Gibberella zeae Appl Environ Microbiol 72 1793 1799 10.1128/AEM.72.3.1793-1799.2006 1:CAS:528:DC%2BD28XjsFCms7o%3D
21. HE Hallen H Luo JS Scott-Craig JD Walton 2007 Gene family encoding the major toxins of lethal Amanita mushrooms Proc Natl Acad Sci USA 104 19097 19101 10.1073/pnas.0707340104 1:CAS:528:DC%2BD2sXhsVSks7%2FM
22. D Hoffmeister NP Keller 2007 Natural products of filamentous fungi: enzymes, genes, and their regulation Nat Prod Rep 24 393 416 10.1039/b603084j 1:CAS:528:DC%2BD2sXlt1Oqsrg%3D (Pubitemid 46496563)
23. Z Hou C Xue Y Peng T Katan HC Kistler JR Xu 2002 A mitogen-activated protein kinase gene (MGV1) in Fusarium graminearum is required for female fertility, heterokaryon formation, and plant infection Mol Plant Microbe Interact 15 1119 1127 10.1094/MPMI.2002.15.11.1119 1:CAS:528: DC%2BD38XosVGru7s%3D
24. SP Kale L Milde MK Trapp JC Frisvad NP Keller JW Bok 2008 Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus Fungal Genet Biol 45 1422 1429 10.1016/j.fgb.2008.06.009 1:CAS:528: DC%2BD1cXht1ejtbbL
25. NP Keller G Turner JW Bennett 2005 Fungal secondary metabolism-from biochemistry to genomics Nat Rev Microbiol 3 937 947 10.1038/nrmicro1286 1:CAS:528:DC%2BD2MXht1OnsLbF (Pubitemid 43078157)
26. YT Kim YR Lee J Jin KH Han H Kim JC Kim T Lee SH Yun YW Lee 2005 Two different polyketide synthase genes are required for synthesis of zearalenone in Gibberella zeae Mol Microbiol 58 1102 1113 10.1111/j.1365-2958.2005.04884.x 1:CAS:528:DC%2BD2MXht12msrnE (Pubitemid 41667228)
27. K Kosalková C García-Estrada RV Ullán RP Godio R Feltrer F Teijeira E Mauriz JF Martín 2009 The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum Biochimie 91 214 225 10.1016/j.biochi.2008.09.004
28. S Kucht J Gross Y Hussein T Grothe U Keller S Basar WA Konig U Steiner E Leistner 2004 Elimination of ergoline alkaloids following treatment of Ipomoea asarifolia (Convolvulaceae) with fungicides Planta 219 619 625 10.1007/s00425-004-1261-2 1:CAS:528:DC%2BD2cXmt1Cqtb0%3D
29. C Kupfahl T Heinekamp G Geginat T Ruppert A Härtl H Hof AA Brakhage 2006 Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model Mol Microbiol 62 292 302 10.1111/j.1365-2958.2006.05373.x 1:CAS:528:DC%2BD28XhtFWgsLnL (Pubitemid 44386567)
30. N Lorenz T Haarmann S Pazoutová M Jung P Tudzynski 2009 The ergot alkaloid gene cluster: functional analyses and evolutionary aspects Phytochemistry 70 1822 1832 10.1016/j.phytochem.2009.05.023 1:CAS:528: DC%2BD1MXhsVWlsL7K
31. H Luo HE Hallen-Adams JD Walton 2009 Processing of the phalloidin proprotein by prolyl oligopeptidase from the mushroom Conocybe albipes J Biol Chem 284 18070 18077 10.1074/jbc.M109.006460 1:CAS:528:DC%2BD1MXnslegtrY%3D
32. E Lysøe SS Klemsdal KR Bone RJ Frandsen T Johansen U Thrane H Giese 2006 The PKS4 gene of Fusarium graminearum is essential for zearalenone production Appl Environ Microbiol 72 3924 3932 10.1128/AEM.00963-05 (Pubitemid 43894853)
33. E Lysøe KR Bone SS Klemsdal 2009 Real-time quantitative expression studies of the zearalenone biosynthetic gene cluster in Fusarium graminearum Phytopathology 99 176 184 10.1094/PHYTO-99-2-0176
34. A Markert N Steffan K Ploss S Hellwig U Steiner C Drewke SM Li W Boland E Leistner 2008 Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a clavicipitalean fungus Plant Physiol 147 296 305 10.1104/pp.108.116699 1:CAS:528:DC%2BD1cXms1eksbw%3D (Pubitemid 352844368)
35. M Matsuura Y Saikawa K Inui K Nakae M Igarashi K Hashimoto M Nakata 2009 Identification of the toxic trigger in mushroom poisoning Nat Chem Biol 5 465 467 10.1038/nchembio.179 1:CAS:528:DC%2BD1MXmtlarsL4%3D
36. RM Perrin ND Fedorova JW Bok RA Cramer JR Wortman HS Kim WC Nierman NP Keller 2007 Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA PLoS Pathog 3 e50 10.1371/journal.ppat.0030050 (Pubitemid 46683486)
37. RH Proctor DW Brown RD Plattner AE Desjardins 2003 Co-expression of 15 contiguous genes delineates a fumonisin biosynthetic gene cluster in Gibberella moniliformis Fungal Genet Biol 38 237 249 10.1016/S1087-1845(02)00525-X 1:CAS:528:DC%2BD3sXhs1CgsL4%3D (Pubitemid 36279665)
38. RH Proctor RD Plattner DW Brown JA Seo YW Lee 2004 Discontinuous distribution of fumonisin biosynthetic genes in the Gibberella fujikuroi species complex Mycol Res 108 815 822 10.1017/S0953756204000577 1:CAS:528: DC%2BD2cXmtlSisr4%3D (Pubitemid 39123301)
39. Reyes-Dominguez Y, Bok JW, Berger H, Shwab EK, Basheer A, Gallmetzer A, Scazzocchio C, Keller N, Strauss J (2010) Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans. Mol Microbiol (in press) doi: 10.1111/j.1365-2958.2010.07051.x
40. K Scherlach C Hertweck 2006 Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining Org Biomol Chem 4 3517 3520 10.1039/b607011f 1:CAS:528:DC%2BD28XovVajt78%3D (Pubitemid 44319640)
41. P Schneider M Weber K Rosenberger D Hoffmeister 2007 A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones Chem Biol 14 635 644 10.1016/j.chembiol.2007.05. 005 1:CAS:528:DC%2BD2sXmvVOgt7w%3D (Pubitemid 46920983)
42. P Schneider S Bouhired D Hoffmeister 2008 Characterization of the atromentin biosynthesis genes and enzymes in the homobasidiomycete Tapinella panuoides Fungal Genet Biol 45 1487 1496 10.1016/j.fgb.2008.08.009 1:CAS:528:DC%2BD1cXhtlGhurfM
43. M Stadler NP Keller 2008 Paradigm shifts in fungal secondary metabolite research Mycol Res 112 127 130 10.1016/j.mycres.2007.12.002 1:CAS:528: DC%2BD1cXlsFOhs7s%3D (Pubitemid 351305475)
44. U Steiner MA Ahimsa-Müller A Markert S Kucht J Gross N Kauf M Kuzma M Zych M Lamshoft M Furmanowa V Knoop C Drewke E Leistner 2006 Molecular characterization of a seed transmitted clavicipitaceous fungus occurring on dicotyledoneous plants (Convolvulaceae) Planta 224 533 544 10.1007/s00425-006- 0241-0 1:CAS:528:DC%2BD28Xnsl2isL8%3D (Pubitemid 44188098)
45. JA Sugui J Pardo YC Chang KA Zarember G Nardone EM Galvez A Müllbacher JI Gallin MM Simon KJ Kwon-Chung 2007 Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone Eukaryot Cell 6 1562 1569 10.1128/EC.00141-07 1:CAS:528:DC%2BD2sXhtVKqt7nK (Pubitemid 47483599)
46. H von Döhren 2009 A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans Fungal Genet Biol 46 Suppl 1 S45 S52 10.1016/j.fgb.2008.08.008