Immunomodulation of Vascular Diseases: Atherosclerosis and Autoimmunity

European Journal of Vascular and Endovascular Surgery

Volumn 39, Issue 4, 2010, Pages 485-494

  Shi, G P ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Adaptive immunity; Atherosclerosis; Autoantibody; Autoantigen; Innate immunity

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CD3 ANTIBODY; FREUND ADJUVANT; IMMUNOGLOBULIN M; RAPAMYCIN;

ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CHEMICAL STRUCTURE; DENDRITIC CELL; DISEASE COURSE; HUMAN; IMMUNOMODULATION; IMMUNOTHERAPY; INFLAMMATORY CELL; MACROPHAGE; MAST CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE; VASCULAR DISEASE; VASCULITIS;

ADAPTIVE IMMUNITY; ANIMALS; ATHEROSCLEROSIS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; BACTERIAL INFECTIONS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; LYMPHOCYTE SUBSETS; TREATMENT OUTCOME; VACCINES;

EID: 77950299042     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1016/j.ejvs.2010.01.028     Document Type: Review

References (60)

1. Hansson G.K., and Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 6 (2006) 508-519
2. Benagiano M., Azzurri A., Ciervo A., Amedei A., Tamburini C., Ferrari M., et al. T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. Proc Natl Acad Sci USA 100 (2003) 6658-6663
3. Zhou X., Nicoletti A., Elhage R., and Hansson G.K. Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice. Circulation 102 (2000) 2919-2922
4. Caligiuri G., Nicoletti A., Poirier B., and Hansson G.K. Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 109 (2002) 745-753
5. Bobryshev Y.V. Dendritic cells in atherosclerosis: current status of the problem and clinical relevance. Eur Heart J 26 (2005) 1700-1704
6. Bot I., de Jager S.C., Zernecke A., Lindstedt K.A., van Berkel T.J., Weber C., et al. Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipoprotein E-deficient mice. Circulation 115 (2007) 2516-2525
7. Sun J., Sukhova G.K., Wolters P.J., Yang M., Kitamoto S., Libby P., et al. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13 (2007) 719-724
8. Shoenfeld Y., Sherer Y., George J., and Harats D. Autoantibodies associated with atherosclerosis. Ann Med 32 Suppl. 1 (2000) 37-40
9. Stemme S., Faber B., Holm J., Wiklund O., Witztum J.L., and Hansson G.K. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci USA 92 (1995) 3893-3897
10. + T cells reactive to modified low-density lipoprotein aggravates atherosclerosis. Arterioscler Thromb Vasc Biol 26 (2006) 864-870
11. Fredrikson G.N., Hedblad B., Berglund G., Alm R., Ares M., Cercek B., et al. Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease. Arterioscler Thromb Vasc Biol 23 (2003) 872-878
12. Perschinka H., Mayr M., Millonig G., Mayerl C., van der Zee R., Morrison S.G., et al. Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis. Arterioscler Thromb Vasc Biol. 23 (2003) 1060-1065
13. Xu Q., Kiechl S., Mayr M., Metzler B., Egger G., Oberhollenzer F., et al. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study. Circulation 100 (1999) 1169-1174
14. Benagiano M., D'Elios M.M., Amedei A., Azzurri A., van der Zee R., Ciervo A., et al. Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques. J Immunol 174 (2005) 6509-6517
15. McNeil H.P., Simpson R.J., Chesterman C.N., and Krilis S.A. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 87 (1990) 4120-4124
16. George J., Harats D., Gilburd B., Afek A., Shaish A., Kopolovic J., et al. Adoptive transfer of beta(2)-glycoprotein I-reactive lymphocytes enhances early atherosclerosis in LDL receptor-deficient mice. Circulation 102 (2000) 1822-1827
17. Manzi S., Meilahn E.N., Rairie J.E., Conte C.G., Medsger Jr. T.A., Jansen-McWilliams L., et al. Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham Study. Am J Epidemiol 145 (1997) 408-415
18. Asanuma Y., Oeser A., Shintani A.K., Turner E., Olsen N., Fazio S., et al. Premature coronary-artery atherosclerosis in systemic lupus erythematosus. N Engl J Med 349 (2003) 2407-2415
19. Braun N., Wade N.S., Wakeland E.K., and Major A.S. Accelerated atherosclerosis is independent of feeding high fat diet in systemic lupus erythematosus-susceptible LDLr(-/-) mice. Lupus 17 (2008) 1070-1078
20. Sherer Y., and Shoenfeld Y. Mechanisms of disease: atherosclerosis in autoimmune diseases. Nat Clin Pract Rheumatol 2 (2006) 99-106
21. Peters M.J., van Halm V.P., Nurmohamed M.T., Damoiseaux J., Tervaert J.W., Twisk J.W., et al. Relations between autoantibodies against oxidized low-density lipoprotein, inflammation, subclinical atherosclerosis, and cardiovascular disease in rheumatoid arthritis. J Rheumatol 35 (2008) 1495-1499
22. Ginsburg K.S., Liang M.H., Newcomer L., Goldhaber S.Z., Schur P.H., Hennekens C.H., et al. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. Ann Intern Med 117 (1992) 997-1002
23. Ma-Krupa W., Jeon M.S., Spoerl S., Tedder T.F., Goronzy J.J., and Weyand C.M. Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. J Exp Med 199 (2004) 173-183
24. Cohen Tervaert J.W. Translational mini-review series on immunology of vascular disease: accelerated atherosclerosis in vasculitis. Clin Exp Immunol 156 (2009) 377-385
25. Slot M.C., Theunissen R., van Paassen P., Damoiseaux J.G., Cohen Tervaert J.W., and Limburg Nephrology Working Group. Anti-oxidized low-density lipoprotein antibodies in myeloperoxidase-positive vasculitis patients preferentially recognize hypochlorite-modified low density lipoproteins. Clin Exp Immunol 149 (2007) 257-264
26. Gruber R., Lederer S., Bechtel U., Lob S., Riethmüller G., and Feucht H.E. Increased antibody titers against mycobacterial heat-shock protein 65 in patients with vasculitis and arteriosclerosis. Int Arch Allergy Immunol 110 (1996) 95-98
27. Espinosa G., Tàssies D., Font J., Muñoz-Rodríguez F.J., Cervera R., Ordinas A., et al. Antiphospholipid antibodies and thrombophilic factors in giant cell arteritis. Semin Arthritis Rheum 31 (2001) 12-20
28. George J. Mechanisms of disease: the evolving role of regulatory T cells in atherosclerosis. Nat Clin Pract Cardiovasc Med 5 (2008) 531-540
29. Yang K., Li D., Luo M., and Hu Y. Generation of HSP60-specific regulatory T cell and effect on atherosclerosis. Cell Immunol 243 (2006) 90-95
30. Ait-Oufella H., Salomon B.L., Potteaux S., Robertson A.K., Gourdy P., Zoll J., et al. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12 (2006) 178-180
31. Palinski W., Miller E., and Witztum J.L. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc Natl Acad Sci USA 92 (1995) 821-825
32. Binder C.J., Hartvigsen K., Chang M.K., Miller M., Broide D., Palinski W., et al. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114 (2004) 427-437
33. van Puijvelde G.H., Hauer A.D., de Vos P., van den Heuvel R., van Herwijnen M.J., van der Zee R., et al. Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis. Circulation 114 (2006) 1968-1976
34. Harats D., Yacov N., Gilburd B., Shoenfeld Y., and George J. Oral tolerance with heat shock protein 65 attenuates mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions. J Am Coll Cardiol 40 (2002) 1333-1338
35. Maron R., Sukhova G., Faria A.M., Hoffmann E., Mach F., Libby P., et al. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 106 (2002) 1708-1715
36. George J., Yacov N., Breitbart E., Bangio L., Shaish A., Gilburd B., et al. Suppression of early atherosclerosis in LDL-receptor deficient mice by oral tolerance with beta 2-glycoprotein I. Cardiovasc Res 62 (2004) 603-609
37. Fredrikson G.N., Söderberg I., Lindholm M., Dimayuga P., Chyu K.Y., Shah P.K., et al. Inhibition of atherosclerosis in ApoE-null mice by immunization with apoB-100 peptide sequences. Arterioscler Thromb Vasc Biol. 23 (2003) 879-884
38. Fredrikson G.N., Andersson L., Söderberg I., Dimayuga P., Chyu K.Y., Shah P.K., et al. Atheroprotective immunization with MDA-modified apo B-100 peptide sequences is associated with activation of Th2 specific antibody expression. Autoimmunity 38 (2005) 171-179
39. Nicoletti A., Paulsson G., Caligiuri G., Zhou X., and Hansson G.K. Induction of neonatal tolerance to oxidized lipoprotein reduces atherosclerosis in ApoE knockout mice. Mol Med 6 (2000) 283-290
40. Binder C.J., Hörkkö S., Dewan A., Chang M.K., Kieu E.P., Goodyear C.S., et al. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between streptococcus pneumoniae and oxidized LDL. Nat Med 9 (2003) 736-743
41. Caligiuri G., Khallou-Laschet J., Vandaele M., Gaston A.T., Delignat S., Mandet C., et al. Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol 50 (2007) 540-546
42. Wigren M., Bengtsson D., Dunér P., Olofsson K., Björkbacka H., Bengtsson E., et al. Atheroprotective effects of alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells. Circ Res 104 (2009) e62-e70
43. George J., Afek A., Gilburd B., Blank M., Levy Y., Aron-Maor A., et al. Induction of early atherosclerosis in LDL-receptor-deficient mice immunized with beta2-glycoprotein I. Circulation 98 (1998) 1108-1115
44. Afek A., George J., Shoenfeld Y., Gilburd B., Levy Y., Shaish A., et al. Enhancement of atherosclerosis in beta-2-glycoprotein I-immunized apolipoprotein E-deficient mice. Pathobiology 67 (1999) 19-25
45. George J., Shoenfeld Y., Afek A., Gilburd B., Keren P., Shaish A., et al. Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65. Arterioscler Thromb Vasc Biol. 19 (1999) 505-510
46. Afek A., George J., Gilburd B., Rauova L., Goldberg I., Kopolovic J., et al. Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis. J Autoimmun 14 (2000) 115-121
47. Xu Q., Dietrich H., Steiner H.J., Gown A.M., Schoel B., Mikuz G., et al. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler Thromb 12 (1992) 789-799
48. Mandal K., Jahangiri M., and Xu Q. Autoimmunity to heat shock proteins in atherosclerosis. Autoimmun Rev 3 (2004) 31-37
49. Palinski W., Hörkkö S., Miller E., Steinbrecher U.P., Powell H.C., Curtiss L.K., et al. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma. J Clin Invest 98 (1996) 800-814
50. Zhou X., Caligiuri G., Hamsten A., Lefvert A.K., and Hansson G.K. LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis. Arterioscler Thromb Vasc Biol 21 (2001) 108-114
51. Xu Q., Schett G., Perschinka H., Mayr M., Egger G., Oberhollenzer F., et al. Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation 102 (2000) 14-20
52. Kol A., Sukhova G.K., Lichtman A.H., and Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 98 (1998) 300-307
53. Xu Q., Schett G., Seitz C.S., Hu Y., Gupta R.S., and Wick G. Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells. Circ Res 75 (1994) 1078-1085
54. Ayada K., Yokota K., Kobayashi K., Shoenfeld Y., Matsuura E., and Oguma K. Chronic infections and atherosclerosis. Ann N Y Acad Sci 1108 (2007) 594-602
55. Brey R.L., Abbott R.D., Curb J.D., Sharp D.S., Ross G.W., Stallworth C.L., et al. Beta(2)-glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction: the Honolulu heart program. Stroke 32 (2001) 1701-1706
56. Kobayashi K., Kishi M., Atsumi T., Bertolaccini M.L., Makino H., Sakairi N., et al. Circulating oxidized LDL forms complexes with beta2-glycoprotein I: implication as an atherogenic autoantigen. J Lipid Res 44 (2003) 716-726
57. van de Ven A., Prakken B., and Albani S. Immunological tolerance in the therapy of rheumatoid arthritis. Discov Med 7 (2007) 46-50
58. Raz I., Elias D., Avron A., Tamir M., Metzger M., and Cohen I.R. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 358 (2001) 1749-1753
59. Holzer A.M., Martiniuk F., and Levis W.R. Heat-shock proteins as drugs: potential applications in cancer, infections, and autoimmune and atopic diseases. J Drugs Dermatol 6 (2007) 393-399
60. Lindblad E.B. Aluminium compounds for use in vaccines. Immunol Cell Biol 82 (2004) 497-505