Complex and cryptic chromosomal rearrangements involving the MLL gene in acute leukemia: A study of 7 patients and review of the literature

Blood Cells, Molecules, and Diseases

Volumn 44, Issue 4, 2010, Pages 268-274

  De Braekeleer, Etienne ^a,b,c   Meyer, Claus ^d   Douet Guilbert, Nathalie ^a,b,c   Morel, Frédéric ^a,b,c   Le Bris, Marie Josée ^c   Berthou, Christian ^c   Arnaud, Bertrand ^e   Marschalek, Rolf ^d   Férec, Claude ^a,b,c   De Braekeleer, Marc ^a,b,c  

^a FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

^b INSERM   (France)

^c CHU MORVAN   (France)

^d GOETHE UNIVERSITY   (Germany)

^e CH de Cornouaille Quimper Concarneau   (France)

Author keywords

Acute leukemia; Complex translocations; Cryptic rearrangements; Fusion genes; MLL

Indexed keywords

MIXED LINEAGE LEUKEMIA PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ACUTE LEUKEMIA; ADULT; AGED; ARTICLE; CHROMOSOME 11; CHROMOSOME DELETION; CHROMOSOME DELETION 11Q; CHROMOSOME INSERTION; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION 6; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE PROBE; GENETIC ASSOCIATION; HUMAN; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ACUTE DISEASE; ADENOCARCINOMA; ADULT; AGED; BLAST CRISIS; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 11; DUODENAL NEOPLASMS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; INFANT, NEWBORN; LEUKEMIA; LEUKEMIA, MONOCYTIC, ACUTE; LEUKEMIA, MYELOMONOCYTIC, ACUTE; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MALE; MUTAGENESIS, INSERTIONAL; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEOPLASMS, SECOND PRIMARY; ONCOGENE PROTEINS, FUSION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROSTATIC NEOPLASMS; SEQUENCE DELETION; TRANSLOCATION, GENETIC;

EID: 77950299029     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2010.02.011     Document Type: Article

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