A highly specific and sensitive fluorescence in situ hybridization assay for the detection of t(4;11)(q21;q23) and concurrent submicroscopic deletions in acute leukaemias

British Journal of Haematology

Volumn 116, Issue 4, 2002, Pages 758-764

  König, Margit ^a   Reichel, Martin ^b   Marschalek, Rolf ^b,c   Haas, Oskar A ^a,d   Strehl, Sabine ^a  

^a CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

AF4 gene; FISH; Fusion transcript; MLL gene; t(4; 11)(q21; q23)

Indexed keywords

ACUTE LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER SCREENING; CHILD; CHIMERA; CHROMOSOME 11; CHROMOSOME REARRANGEMENT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; FEMALE; FLUORESCENCE ANALYSIS; GENE DELETION; GENE FUSION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; IN SITU HYBRIDIZATION; INFANT; MALE; METASTASIS; MOLECULAR CLONING; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

3' FLANKING REGION; ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 4; CYTOGENETIC ANALYSIS; FEMALE; GENE DELETION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; INTERPHASE; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; METAPHASE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSLOCATION, GENETIC;

EID: 0036121966     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0007-1048.2002.03340.x     Document Type: Article

References (31)

1. Rapid and sensitive detection of all types of MLL gene translocations with a single FISH probe set
2. A DNA probe combination for improved detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias
3. Cryptic t(4;11) encoding MLL-AF4 due to insertion of 5′ MLL sequences in chromosome 4
4. Sensitivity of FISH in detection of MLL translocations
5. MLL rearrangements in haematological malignancies: Lessons from clinical and biological studies
6. The der (11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia
7. Leukemia in infants
8. The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7
9. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
10. The detection and significance of chromosomal abnormalities in childhood acute lymphoblastic leukaemia
11. Cytogenetic studies of infant acute lymphoblastic leukemia: Poor prognosis of infants with t(4;11) - A report of the Children's Cancer Group
12. 11q23 Rearrangements in leukaemia
13. An Atlas on chromosomes in hematological malignancies. Example: 11q23 and MLL Partners
14. Hematologic malignancies with t(4;11)(q21;q23) - A cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. European 11q23 Workshop participants
15. The impact of the new FISH technologies on the cytogenetics of haematological malignancies
16. Chromosome 11q23 translocations in both infant and adult acute leukemias are detected by in situ hybridization with a yeast artificial chromosome
17. Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis
18. The biological significance of the multidrug resistance gene MRP in inversion 16 leukemias
19. Molecular characterization of 16p deletions associated with inversion 16 defines the critical fusion for leukemogenesis
20. Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;11)
21. Molecular cytogenetics of childhood hematological malignancies
22. A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia
23. Fluorescence in situ hybridization: Molecular probes for diagnosis of pediatric neoplastic diseases
24. Chromosomal abnormalities in 478 children with acute myeloid leukemia: Clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821
25. Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: Implications for basic and clinical research
26. Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL
27. Rearrangements involving chromosome band 11q23 in acute leukaemia
28. Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: Identification of 11q23 translocation breakpoints with a yeast artificial chromosome
29. Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia
30. Multiplex reverse transcriptase-polymerase chain reaction screening in childhood acute myeloblastic leukemia