MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia

Cancer Genetics and Cytogenetics

Volumn 168, Issue 2, 2006, Pages 162-167

  Kadkol, ShriHari S ^a   Bruno, Annette ^a   Oh, Steven ^a   Schmidt, Mary Lou ^a   Lindgren, Valerie ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ACUTE GRANULOCYTIC LEUKEMIA; ANAMNESIS; ARTICLE; CANCER CHEMOTHERAPY; CARCINOGENESIS; CASE REPORT; CELL POLARITY; CHROMOSOME 11Q; CHROMOSOME XQ; CLINICAL FEATURE; CORRELATION ANALYSIS; CYTOGENETICS; CYTOKINESIS; DISEASE ASSOCIATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE FUSION; GENE LOCATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; LABORATORY TEST; MALE; MLL GENE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPT6 GENE;

BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, X; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; KARYOTYPING; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; ONCOGENE PROTEINS, FUSION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 33745726045     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2006.02.020     Document Type: Article

References (13)

1. Eguchi M., Eguchi-Ishimae M., and Greaves M. The role of the MLL gene in infant leukemia. Int J Hematol 78 (2003) 390-401
2. Collins E.C., and Rabbitts T.H. The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. Trends Mol Med 8 (2002) 436-442
3. Felix C.A., Hosler M.R., Winick N.J., Masterson M., Wilson A.E., and Lange B.J. ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children. Blood 85 (1995) 3250-3256
4. Borkhardt A., Teigler-Schlegel A., Fuchs U., Keller C., Konig M., Harbott J., and Haas O.A. An ins(X;11)(q24;q23) fuses the MLL and the Septin 6/KIAA0128 gene in an infant with AML-M2. Genes Chromosomes Cancer 32 (2001) 82-88
5. Slater D.J., Hilgenfeld E., Rappaport E.F., Shah N., Meek R.G., Williams W.R., Lovett B.D., Osheroff N., Autar R.S., Ried T., and Felix C.A. MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site. Oncogene 21 (2002) 4706-4714
6. Kim H.J., Ki C.S., Park Q., Koo H.H., Yoo K.H., Kim E.J., and Kim S.H. MLL/SEPTIN6 chimeric transcript from inv ins(X;11)(q24;q23q13) in acute monocytic leukemia: report of a case and review of the literature. Genes Chromosomes Cancer 38 (2003) 8-12
7. Fu J.F., Liang D.C., Yang C.P., Hsu J.J., and Shih L.Y. Molecular analysis of t(X;11)(q24;q23) in an infant with AML-M4. Genes Chromosomes Cancer 38 (2003) 253-259
8. Ono R., Taki T., Taketani T., Kawaguchi H., Taniwaki M., Okamura T., Kawa K., Hanada R., Kobayashi M., and Hayashi Y. SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24. Cancer Res 62 (2002) 333-337
9. Arnaud B., Morel F., Douet-Guilbert N., Le Bris M.J., and De Braekeleer M. X chromosome insertion in the MLL gene in a case of childhood acute myeloblastic leukemia. Cancer Genet Cytogenet 152 (2004) 149-152
10. Faty M., Fink M., and Barral Y. Septins: a ring to part mother and daughter. Curr Genet 41 (2002) 123-131
11. Macara I.G., Baldarelli R., Field C.M., Glotzer M., Hayashi Y., Hsu S.C., Kennedy M.B., Kinoshita M., Longtine M., Low C., Maltais L.J., McKenzie L., Mitchison T.J., Nishikawa T., Noda M., Petty E.M., Peifer M., Pringle J.R., Robinson P.J., Roth D., Russell S.E., Stuhlmann H., Tanaka M., Tanaka T., Trimble W.S., Ware J., Zeleznik-Le N.J., and Zieger B. Mammalian septins nomenclature. Mol Biol Cell 13 (2002) 4111-4113
12. Kartmann B., and Roth D. Novel roles for mammalian septins: from vesicle trafficking to oncogenesis. J Cell Sci 114 (2001) 839-844
13. van der Burg M., Poulsen T.S., Hunger S.P., Beverloo H.B., Smit E.M., Vang-Nielsen K., Langerak A.W., and van Dongen J.J. Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia. Leukemia 18 (2004) 895-908