MLL-AF6 fusion resulting from a new three-way translocation t(6;11;7) in a patient with acute myeloid leukemia [8]

Leukemia

Volumn 15, Issue 10, 2001, Pages 1674-1676

  Giugliano, E ^a,b   Rege Cambrin, G ^a   Scaravaglio, P ^a   Serra, A ^a   Wlodarska, I ^b   Emanuel, B ^b   Saglio, G ^a   Hagemeijer, A ^b  

^a SAN LUIGI GONZAGA HOSPITAL   (Italy)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; ETOPOSIDE; HYBRID PROTEIN; MITOXANTRONE; ONCOPROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; BONE MARROW CELL; CASE REPORT; CHROMOSOME 11Q; CHROMOSOME ANALYSIS; CHROMOSOME BAND; CHROMOSOME BREAKAGE; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 6; CHROMOSOME TRANSLOCATION 7; DEATH; DISEASE ASSOCIATION; EXON; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; GENE MAPPING; GENE REARRANGEMENT; HUMAN; KARYOTYPING; LETTER; METAPHASE; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT FAILURE; TRISOMY 8;

EID: 0034781828     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402213     Document Type: Letter

References (11)

1. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations
2. The structure of the human ALL-1/MLL/HRX gene
3. ALL1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between alu elements
4. Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II
5. Molecular genetics of 11q23 chromosome translocation
6. A DNA probe combination for improved detection of MLL/11q23 breakpoints by dual color Interphase-FISH in acute leukemias
7. Cloning of the ALL-1 fusion partner, the AF6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation
8. A FISH study of variant Philadelphia rearrangements
9. Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia
10. Detection of four different 11q23 chromosomal abnormalities by multiplex-PCI and fluorescence-based automatic DNA-fragment analysis
11. The t(6;11)(q27;23) translocation in acute leukemia: A laboratory and clinical study of 30 cases