Asymmetrie synthesis of bicyclic diol derivatives through metal and enzyme catalysis: Application to the formal synthesis of sertraline

Chemistry - A European Journal

Volumn 16, Issue 13, 2010, Pages 4031-4036

  Krumlinde, Patrik ^a   Bogár, Krisztián ^a,b   Bäckvall, Jan E ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Alcohols; Asymmetric catalysis; Dynamic resolution; Enzyme catalysis; Metal catalysis

Indexed keywords

ENANTIOSELECTIVITY; ENZYMES; ESTERS; RUTHENIUM; SYNTHESIS (CHEMICAL);

ASYMMETRIC CATALYSIS; DIASTEREOMERIC PURITY; DIASTEREOSELECTIVE; DYNAMIC KINETIC ASYMMETRIC TRANSFORMATIONS; DYNAMIC RESOLUTION; ENANTIO; ENANTIOSELECTIVE SYNTHESIS; ENZYME CATALYSIS; ENZYME-CATALYZED ESTER; FORMAL SYNTHESIS; HIGH ENANTIOSELECTIVITY; HIGH YIELD; METAL CATALYSIS; SERTRALINE;

CATALYSIS;

ALCOHOL DERIVATIVE; BICYCLO COMPOUND; ORGANOMETALLIC COMPOUND; RUTHENIUM; SERTRALINE;

ARTICLE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HYDROLYSIS; KINETICS; STEREOISOMERISM; SYNTHESIS;

ALCOHOLS; BICYCLO COMPOUNDS; BIOCATALYSIS; CHEMICAL SYNTHESIS; CHEMISTRY; HYDROLYSIS; KINETICS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; RUTHENIUM; SERTRALINE; STEREOISOMERISM;

EID: 77950279207     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200903114     Document Type: Article

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