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Volumn 78, Issue 4, 2010, Pages 1447-1456

Pseudomonas aeruginosa cytotoxin ExoU is injected into phagocytic cells during acute pneumonia

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; CYTOTOXIN; EXOU; UNCLASSIFIED DRUG;

EID: 77950271943     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01134-09     Document Type: Article
Times cited : (81)

References (42)
  • 1
    • 0033916705 scopus 로고    scopus 로고
    • Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread
    • Allewelt, M., F. T. Coleman, M. Grout, G. P. Priebe, and G. B. Pier. 2000. Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread. Infect. Immun. 68:3998-4004.
    • (2000) Infect. Immun. , vol.68 , pp. 3998-4004
    • Allewelt, M.1    Coleman, F.T.2    Grout, M.3    Priebe, G.P.4    Pier, G.B.5
  • 3
    • 3843065509 scopus 로고    scopus 로고
    • Identification of the secretion and translocation domain of the enteropathogenic and enterohemorrhagic Escherichia coli effector Cif, using TEM-1 beta-lactamase as a new fluorescencebased reporter
    • Charpentier, X., and E. Oswald. 2004. Identification of the secretion and translocation domain of the enteropathogenic and enterohemorrhagic Escherichia coli effector Cif, using TEM-1 beta-lactamase as a new fluorescencebased reporter. J. Bacteriol. 186:5486-5495.
    • (2004) J. Bacteriol. , vol.186 , pp. 5486-5495
    • Charpentier, X.1    Oswald, E.2
  • 5
    • 0032968052 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia
    • Comolli, J. C., A. R. Hauser, L. Waite, C. B. Whitchurch, J. S. Mattick, and J. N. Engel. 1999. Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia. Infect. Immun. 67:3625-3630.
    • (1999) Infect. Immun. , vol.67 , pp. 3625-3630
    • Comolli, J.C.1    Hauser, A.R.2    Waite, L.3    Whitchurch, C.B.4    Mattick, J.S.5    Engel, J.N.6
  • 6
    • 53649100267 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa induces localized immunosuppression during pneumonia in mammals
    • Diaz, M. H., C. M. Shaver, J. D. King, S. Musunuri, J. A. Kazzaz, and A. R. Hauser. 2008. Pseudomonas aeruginosa induces localized immunosuppression during pneumonia in mammals. Infect. Immun. 76:4414-4421.
    • (2008) Infect. Immun. , vol.76 , pp. 4414-4421
    • Diaz, M.H.1    Shaver, C.M.2    King, J.D.3    Musunuri, S.4    Kazzaz, J.A.5    Hauser, A.R.6
  • 7
    • 0028881698 scopus 로고
    • Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8
    • DiMango, E., H. Zar, R. Bryan, and A. Prince. 1995. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J. Clin. Invest. 96:2204-2210.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2204-2210
    • DiMango, E.1    Zar, H.2    Bryan, R.3    Prince, A.4
  • 8
    • 0034769748 scopus 로고    scopus 로고
    • Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa
    • Feltman, H., G. Schulert, S. Khan, M. Jain, L. Peterson, and A. R. Hauser. 2001. Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Microbiology 147:2659-2669.
    • (2001) Microbiology , vol.147 , pp. 2659-2669
    • Feltman, H.1    Schulert, G.2    Khan, S.3    Jain, M.4    Peterson, L.5    Hauser, A.R.6
  • 9
    • 0034977803 scopus 로고    scopus 로고
    • Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU
    • Finck-Barbançon, V., and D. W. Frank. 2001. Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU. J. Bacteriol. 183: 4330-4344.
    • (2001) J. Bacteriol. , vol.183 , pp. 4330-4344
    • Finck-Barbançon, V.1    Frank, D.W.2
  • 11
    • 37849026512 scopus 로고    scopus 로고
    • Analysis of cells targeted by Salmonella type III secretion in vivo
    • Geddes, K., F. Cruz, and F. Heffron. 2007. Analysis of cells targeted by Salmonella type III secretion in vivo. PLoS Pathog. 3:e196.
    • (2007) PLoS Pathog. , vol.3
    • Geddes, K.1    Cruz, F.2    Heffron, F.3
  • 12
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon, S., and P. R. Taylor. 2005. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5:953-964.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 13
    • 0036191393 scopus 로고    scopus 로고
    • Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa
    • Hauser, A. R., E. Cobb, M. Bodí, D. Mariscal, J. Vallés, J. N. Engel, and J. Rello. 2002. Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Crit. Care Med. 30:521-528.
    • (2002) Crit. Care Med. , vol.30 , pp. 521-528
    • Hauser, A.R.1    Cobb, E.2    Bodí, M.3    Mariscal, D.4    Vallés, J.5    Engel, J.N.6    Rello, J.7
  • 14
    • 0031917203 scopus 로고    scopus 로고
    • PepA, a novel secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence
    • Hauser, A. R., P. J. Kang, and J. Engel. 1998. PepA, a novel secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence. Mol. Microbiol. 27:807-818.
    • (1998) Mol. Microbiol. , vol.27 , pp. 807-818
    • Hauser, A.R.1    Kang, P.J.2    Engel, J.3
  • 15
    • 0038579078 scopus 로고    scopus 로고
    • Rapid recruitment of inflammatory monocytes is independent of neutrophil migration
    • Henderson, R. B., J. A. Hobbs, M. Mathies, and N. Hogg. 2003. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 102:328-335.
    • (2003) Blood , vol.102 , pp. 328-335
    • Henderson, R.B.1    Hobbs, J.A.2    Mathies, M.3    Hogg, N.4
  • 16
    • 0033968474 scopus 로고    scopus 로고
    • Integration-proficient plasmids for Pseudomonas aeruginosa: Site-specific integration and use for engineering of reporter and expression strains
    • Hoang, T. T., A. J. Kutchma, A. Becher, and H. P. Schweizer. 2000. Integration- proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains. Plasmid 43:59-72.
    • (2000) Plasmid , vol.43 , pp. 59-72
    • Hoang, T.T.1    Kutchma, A.J.2    Becher, A.3    Schweizer, H.P.4
  • 17
    • 70049090384 scopus 로고    scopus 로고
    • Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model
    • Koberle, M., A. Klein-Gunther, M. Schutz, M. Fritz, S. Berchtold, E. Tolosa, I. B. Autenrieth, and E. Bohn. 2009. Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model. PLoS Pathog. 5:e1000551.
    • (2009) PLoS Pathog. , vol.5
    • Koberle, M.1    Klein-Gunther, A.2    Schutz, M.3    Fritz, M.4    Berchtold, S.5    Tolosa, E.6    Autenrieth, I.B.7    Bohn, E.8
  • 18
    • 77950262161 scopus 로고    scopus 로고
    • Reference deleted
    • Reference deleted.
  • 19
    • 0031813752 scopus 로고    scopus 로고
    • Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia
    • Kooguchi, K., S. Hashimoto, A. Kobayashi, Y. Kitamura, I. Kudoh, J. Wiener- Kronish, and T. Sawa. 1998. Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia. Infect. Immun. 66:3164-3169.
    • (1998) Infect. Immun. , vol.66 , pp. 3164-3169
    • Kooguchi, K.1    Hashimoto, S.2    Kobayashi, A.3    Kitamura, Y.4    Kudoh, I.5    Wiener- Kronish, J.6    Sawa, T.7
  • 21
    • 15544380187 scopus 로고    scopus 로고
    • Activities of Pseudomonas aeruginosa effectors secreted by the type III secretion system in vitro and during infection
    • Lee, V. T., R. S. Smith, B. Tummler, and S. Lory. 2005. Activities of Pseudomonas aeruginosa effectors secreted by the type III secretion system in vitro and during infection. Infect. Immun. 73:1695-1705.
    • (2005) Infect. Immun. , vol.73 , pp. 1695-1705
    • Lee, V.T.1    Smith, R.S.2    Tummler, B.3    Lory, S.4
  • 22
    • 0036225688 scopus 로고    scopus 로고
    • Lung infections associated with cystic fibrosis
    • Lyczak, J. B., C. L. Cannon, and G. B. Pier. 2002. Lung infections associated with cystic fibrosis. Clin. Microbiol. Rev. 15:194-222.
    • (2002) Clin. Microbiol. Rev. , vol.15 , pp. 194-222
    • Lyczak, J.B.1    Cannon, C.L.2    Pier, G.B.3
  • 25
    • 38849122594 scopus 로고    scopus 로고
    • Real-time analysis of effector translocation by the type III secretion system of enteropathogenic Escherichia coli
    • Mills, E., K. Baruch, X. Charpentier, S. Kobi, and I. Rosenshine. 2008. Real-time analysis of effector translocation by the type III secretion system of enteropathogenic Escherichia coli. Cell Host Microbe 3:104-113.
    • (2008) Cell Host Microbe , vol.3 , pp. 104-113
    • Mills, E.1    Baruch, K.2    Charpentier, X.3    Kobi, S.4    Rosenshine, I.5
  • 26
    • 0021257575 scopus 로고
    • Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S
    • Nicas, T. I., and B. H. Iglewski. 1984. Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S. Infect. Immun. 45:470-474.
    • (1984) Infect. Immun. , vol.45 , pp. 470-474
    • Nicas, T.I.1    Iglewski, B.H.2
  • 27
    • 0142135037 scopus 로고    scopus 로고
    • In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors
    • Phillips, R. M., D. A. Six, E. A. Dennis, and P. Ghosh. 2003. In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J. Biol. Chem. 278:41326-41332.
    • (2003) J. Biol. Chem. , vol.278 , pp. 41326-41332
    • Phillips, R.M.1    Six, D.A.2    Dennis, E.A.3    Ghosh, P.4
  • 28
    • 33646374906 scopus 로고    scopus 로고
    • A C-terminal domain targets the Pseudomonas aeruginosa cytotoxin ExoU to the plasma membrane of host cells
    • Rabin, S. D., J. L. Veesenmeyer, K. T. Bieging, and A. R. Hauser. 2006. A C-terminal domain targets the Pseudomonas aeruginosa cytotoxin ExoU to the plasma membrane of host cells. Infect. Immun. 74:2552-2561.
    • (2006) Infect. Immun. , vol.74 , pp. 2552-2561
    • Rabin, S.D.1    Veesenmeyer, J.L.2    Bieging, K.T.3    Hauser, A.R.4
  • 29
    • 11144265658 scopus 로고    scopus 로고
    • Functional regions of the Pseudomonas aeruginosa cytotoxin ExoU
    • Rabin, S. D. P., and A. R. Hauser. 2005. Functional regions of the Pseudomonas aeruginosa cytotoxin ExoU. Infect. Immun. 73:573-582.
    • (2005) Infect. Immun. , vol.73 , pp. 573-582
    • Rabin, S.D.P.1    Hauser, A.R.2
  • 30
    • 15744390343 scopus 로고    scopus 로고
    • Etiology of ventilator-associated pneumonia
    • Rello, J., E. Diaz, and A. Rodriguez. 2005. Etiology of ventilator-associated pneumonia. Clin. Chest Med. 26:87-95.
    • (2005) Clin. Chest Med. , vol.26 , pp. 87-95
    • Rello, J.1    Diaz, E.2    Rodriguez, A.3
  • 33
    • 4444342607 scopus 로고    scopus 로고
    • ExoU is a potent intracellular phospholipase
    • Sato, H., and D. W. Frank. 2004. ExoU is a potent intracellular phospholipase. Mol. Microbiol. 53:1279-1290.
    • (2004) Mol. Microbiol. , vol.53 , pp. 1279-1290
    • Sato, H.1    Frank, D.W.2
  • 35
    • 0346256754 scopus 로고    scopus 로고
    • Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia
    • Schulert, G. S., H. Feltman, S. D. P. Rabin, C. G. Martin, S. E. Battle, J. Rello, and A. R. Hauser. 2003. Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia. J. Infect. Dis. 188:1695-1706.
    • (2003) J. Infect. Dis. , vol.188 , pp. 1695-1706
    • Schulert, G.S.1    Feltman, H.2    Rabin, S.D.P.3    Martin, C.G.4    Battle, S.E.5    Rello, J.6    Hauser, A.R.7
  • 36
    • 30744443237 scopus 로고    scopus 로고
    • Interactions between effector proteins of the Pseudomonas aeruginosa type III secretion system do not significantly affect several measures of disease severity in mammals
    • Shaver, C. M., and A. R. Hauser. 2006. Interactions between effector proteins of the Pseudomonas aeruginosa type III secretion system do not significantly affect several measures of disease severity in mammals. Microbiology 152:143-152.
    • (2006) Microbiology , vol.152 , pp. 143-152
    • Shaver, C.M.1    Hauser, A.R.2
  • 37
    • 9244236027 scopus 로고    scopus 로고
    • Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung
    • Shaver, C. M., and A. R. Hauser. 2004. Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung. Infect. Immun. 72:6969-6977.
    • (2004) Infect. Immun. , vol.72 , pp. 6969-6977
    • Shaver, C.M.1    Hauser, A.R.2
  • 38
    • 0021027842 scopus 로고
    • A broad host range mobilization system for in vivo genetic engineering: Transposon mutagenesis in gram negative bacteria
    • NY
    • Simon, R., U. Priefer, and A. Puhler. 1983. A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in gram negative bacteria. Biotechnology (NY) 1:784-791.
    • (1983) Biotechnology , vol.1 , pp. 784-791
    • Simon, R.1    Priefer, U.2    Puhler, A.3
  • 39
    • 77049313195 scopus 로고
    • Acetylornithinase of Escherichia coli partial purification and some properties
    • Vogel, H. J., and D. M. Bonner. 1956. Acetylornithinase of Escherichia coli partial purification and some properties. J. Biol. Chem. 218:97-106.
    • (1956) J. Biol. Chem. , vol.218 , pp. 97-106
    • Vogel, H.J.1    Bonner, D.M.2
  • 40
    • 0038153119 scopus 로고    scopus 로고
    • Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa
    • Wolfgang, M. C., B. R. Kulasekara, X. Liang, D. Boyd, K. Wu, Q. Yang, C. G. Miyada, and S. Lory. 2003. Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U. S. A. 100:8484-8489.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 8484-8489
    • Wolfgang, M.C.1    Kulasekara, B.R.2    Liang, X.3    Boyd, D.4    Wu, K.5    Yang, Q.6    Miyada, C.G.7    Lory, S.8


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