New eremophilane sesquiterpenoid compounds, eremoxylarins A and B directly inhibit calcineurin in a manner independent of immunophilin

Journal of Antibiotics

Volumn 61, Issue 8, 2008, Pages 496-502

  Ogasawara, Yukiko ^a   Yoshida, Jun ^a   Shiono, Yoshihito ^b   Miyakawa, Tokichi ^c   Kimura, Ken Ichi ^a  

^a IWATE UNIVERSITY   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Calcineurin (PP2B); Calcium signaling; Eremophilane sesquiterpene; Eremoxylarin; Saccharomyces cerevisiae

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; EREMOPHILANE DERIVATIVE; EREMOXYLARIN A; EREMOXYLARIN B; SESQUITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; COMPETITIVE INHIBITION; DRUG STRUCTURE; FUNGAL STRAIN; FUNGUS MUTANT; IC 50; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; CALCINEURIN; CALCIUM SIGNALING; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOPHILINS; IMMUNOSUPPRESSIVE AGENTS; INHIBITORY CONCENTRATION 50; LITHIUM CHLORIDE; MOLECULAR SEQUENCE DATA; NAPHTHALENES; SACCHAROMYCES CEREVISIAE; SESQUITERPENES;

SACCHAROMYCES CEREVISIAE;

EID: 57849138021     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.66     Document Type: Article

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