Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: A randomized controlled trial

JAMA

Volumn 287, Issue 5, 2002, Pages 598-605

  Jula, Antti ^a   Marniemi, Jukka ^a   Huupponen, Risto ^b   Virtanen, Arja ^a   Rastas, Merja ^a   Rönnemaa, Tapani ^b  

^a SOCIAL INSURANCE INSTITUTION   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; APOLIPOPROTEIN B; BETA CAROTENE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; PLACEBO; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; SIMVASTATIN; TRIACYLGLYCEROL; UBIQUINOL CYTOCHROME C REDUCTASE; VITAMIN;

ADULT; ARTICLE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET THERAPY; DIETARY FIBER; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; DRUG EFFECT; FINLAND; FOOD COMPOSITION; FRUIT; HUMAN; HYPERCHOLESTEROLEMIA; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; VEGETABLE; VITAMIN BLOOD LEVEL;

EID: 0037028782     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.287.5.598     Document Type: Article

References (32)

1. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian simvastatin survival study (4S)
2. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
3. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and Reinfarction Trial (DART)
4. Mediterranean alpha-linoleic acid-rich diet in secondary prevention of coronary heart disease
5. Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: Results of one year follow up
6. Calculated vs analysed nutrient composition of weight reduction diets
7. Classification of hyperlipidemias and hyperlipoproteinaemias
8. The homeostasis model in the San Antonio heart study
9. Retinol, alpha-tocopherol, lycopene, and alpha- and beta-carotene simultaneously determined in plasma by isocratic liquid chromatography
10. A rapid manual method for routine assay of ascorbic acid in serum and plasma
11. Simultaneous determination of reduced and oxidized ubiquinones
12. Simple methods of quantifying oxidation products and antioxidant potential of low density lipoproteins
13. A simple specific method for precipitation of low density lipoproteins
14. Monounsaturated versus polyunsaturated dietary fat and serum lipids: A meta-analysis
15. Plasma lipid and lipoprotein responses to dietary fat and cholesterol: A meta-analysis
16. Cholesterol-lowering effects of dietary fiber: A meta-analysis
17. The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia
18. The effect of simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia
19. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin
20. The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle
21. Distribution of α-tocopherol in human plasma lipoproteins
22. Simvastatin decreases aldehyde production derived from lipoprotein oxidation
23. Decreased in vitro oxidizability of low density lipoprotein in hypercholesterolaemic patients treated with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors
24. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids
25. Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men
26. Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women
27. Effect of the membrane lipid environment on the properties of insulin receptor
28. Insulin stimulation of glucose uptake can be mediated by diacylglycerol in adipocytes
29. A comparison between the effects of gemfibrozil and simvastatin on insulin sensitivity in patients with non-insulin dependent diabetes mellitus and hyperlipoproteinemia
30. The effects of lipid lowering drugs on metabolic control and lipoprotein composition in type 2 diabetic patients with mild hyperlipidemia
31. Lack of effects of simvastatin on insulin sensitivity in type 2 diabetic patients with hypercholesterolemia: Results from a double-blind, randomized, placebo-controlled crossover study
32. Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients