α-Ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain

Brain Research

Volumn 1324, Issue , 2010, Pages 75-84

  Amaral, Alexandre Umpierrez ^a   Leipnitz, Guilhian ^a   Fernandes, Carolina Gonçalves ^a   Seminotti, Bianca ^a   Schuck, Patrícia Fernanda ^c   Wajner, Moacir ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

Author keywords

Hydroxyisovaleric acid; Ketoglutarate dehydrogenase; Ketoisocaproic acid; Brain bioenergetic homeostasis; Leucine; Maple syrup urine disease

Indexed keywords

2 HYDROXYISOVALERIC ACID; 2 OXOGLUTARIC ACID; 2 OXOISOCAPROIC ACID; ADENOSINE DIPHOSPHATE; GLUTAMIC ACID; LEUCINE; MALIC ACID; OXOGLUTARATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCCINIC ACID; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BIOENERGY; BRAIN; CITRIC ACID CYCLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; FOREBRAIN; HOMEOSTASIS; IN VITRO STUDY; MAPLE SYRUP URINE DISEASE; MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM AGENTS; ELECTRON TRANSPORT; HOMEOSTASIS; KETO ACIDS; KETOGLUTARATE DEHYDROGENASE COMPLEX; LEUCINE; MAPLE SYRUP URINE DISEASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIAL DISEASES; MITOCHONDRIAL SWELLING; NADP; OXYGEN CONSUMPTION; PROSENCEPHALON; RATS; RATS, WISTAR; VALERATES;

ACER; RATTUS;

EID: 77949913454     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.02.018     Document Type: Article

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