Increased synthesis of leukotrienes in the mouse model of diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 3, 2010, Pages 1699-1708

  Talahalli, Ramaprasad ^a   Zarini, Simona ^b   Sheibani, Nader ^c   Murphy, Robert C ^b   Gubitosi Klug, Rose A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CALCIMYCIN; GLUCOSE; ISOPHANE INSULIN; LEUKOTRIENE; LEUKOTRIENE A4; LEUKOTRIENE B4; MESSENGER RNA; STREPTOZOCIN; LEUKOTRIENE B4 RECEPTOR; LTB4R1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL DEATH; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENDOTHELIUM CELL; GLIA CELL; LIPOGENESIS; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA CELL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; APOPTOSIS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GENETICS; GLIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERGLYCEMIA; METABOLISM; PATHOLOGY; RETINA; RETINA BLOOD VESSEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

ANIMALS; APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; BLOTTING, WESTERN; BONE MARROW CELLS; CALCIMYCIN; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIUM, VASCULAR; GLUCOSE; HYPERGLYCEMIA; LEUKOTRIENE A4; LEUKOTRIENE B4; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; NEUROGLIA; RECEPTORS, LEUKOTRIENE B4; RETINA; RETINAL VESSELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77949900429     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3557     Document Type: Article

References (39)

1. Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes. 1998;47:1953-1959.
2. Antonetti DA, Lieth E, Barber AJ, Gardner TW. Molecular mechanisms of vascular permeability in diabetic retinopathy. Semin Ophthalmol. 1999;14:240-248.
3. Du Y, Miller CM, Kern TS. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Radical Biol Med. 2003;35:1491-1499.
4. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Nakamura M. New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets. Diabetes Technol Ther. 2000;2:601-608.
5. Joussen AM, Poulaki V, Le ML, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004;18: 1450-1452.
6. Kowluru RA, Chan PS. Oxidative stress and diabetic retinopathy. Exp Diabetes Res. 2007;2007:43603.
7. Aguilar E, Friedlander M, Gariano RF. Endothelial proliferation in diabetic retinal microaneurysms. Arch Ophthalmol. 2003;121: 740-741.
8. Cogan DG, Kuwabara T. The mural cell in perspective. Arch Ophthalmol. 1967;78:133-139.
9. Engerman RL. Pathogenesis of diabetic retinopathy. Diabetes. 1989;38:1203-1206.
10. Gubitosi-Klug RA, Talahalli R, Du Y, Nadler JL, Kern TS. 5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy. Diabetes. 2008;57:1387-1393.
11. Murphy RC, Gijon MA. Biosynthesis and metabolism of leukotrienes. Biochem J. 2007;405:379-395.
12. Fitzpatrick FA, Morton DR, Wynalda MA. Albumin stabilizes leukotriene A4. J Biol Chem. 1982;257:4680-4683.
13. Islam SA, Thomas SY, Hess C, et al. The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans. Blood. 2006;107:444-453.
14. Lundeen KA, Sun B, Karlsson L, Fourie AM. Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells. J Immunol. 2006;177:3439-3447.
15. Pompeia C, Freitas JJ, Kim JS, Zyngier SB, Curi R. Arachidonic acid cytotoxicity in leukocytes: implications of oxidative stress and eicosanoid synthesis. Biol Cell. 2002;94:251-265.
16. Austen KF. The mast cell and the cysteinyl leukotrienes. Novartis Found Symp. 2005;271:166-175; discussion 176-168, 198-169.
17. Letts LG. Leukotrienes: role in cardiovascular physiology. Cardiovasc Clin. 1987;18:101-113.
18. Maekawa A, Kanaoka Y, Xing W, Austen KF. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. Proc Natl Acad Sci U S A. 2008;105:16695-16700.
19. Osher E, Weisinger G, Limor R, Tordjman K, Stern N. The 5 lipoxygenase system in the vasculature: emerging role in health and disease. Mol Cell Endocrinol. 2006;252:201-206.
20. Peters-Golden M. Expanding roles for leukotrienes in airway inflammation. Curr Allergy Asthma Rep. 2008;8:367-373.
21. Crooks SW, Stockley RA. Leukotriene B4. Int J Biochem Cell Biol. 1998;30:173-178.
22. Cuzzocrea S, Rossi A, Mazzon E, et al. 5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration. Lab Invest. 2005;85:808-822.
23. Farooqui AA, Horrocks LA, Farooqui T. Modulation of inflammation in brain: a matter of fat. J Neurochem. 2007;101:577-599.
24. Huang XJ, Zhang WP, Li CT, et al. Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. Glia. 2008;56:27-37.
25. Mathis S, Jala VR, Haribabu B. Role of leukotriene B4 receptors in rheumatoid arthritis. Autoimmun Rev. 2007;7:12-17.
26. Sharma JN, Mohammed LA. The role of leukotrienes in the pathophysiology of inflammatory disorders: is there a case for revisiting leukotrienes as therapeutic targets? Inflammopharmacology. 2006;14:10-16.
27. Fabre JE, Goulet JL, Riche E, et al. Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo. J Clin Invest. 2002;109:1373-1380.
28. Folco G, Murphy RC. Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol Rev. 2006;58:375-388.
29. Farias SE, Zarini S, Precht T, Murphy RC, Heidenreich KA. Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. J Neurochem. 2007;103:1310-1318.
30. Gijon MA, Zarini S, Murphy RC. Biosynthesis of eicosanoids and transcellular metabolism of leukotrienes in murine bone marrow cells. J Lipid Res. 2007;48:716-725.
31. Scheef E, Wang S, Sorenson CM, Sheibani N. Isolation and characterization of murine retinal astrocytes. Mol Vis. 2005;11:613-624.
32. Su X, Sorenson CM, Sheibani N. Isolation and characterization of murine retinal endothelial cells. Mol Vis. 2003;9:171-178.
33. Carrier DJ, Bogri T, Cosentino GP, Guse I, Rakhit S, Singh K. HPLC studies on leukotriene A4 obtained from the hydrolysis of its methyl ester. Prostaglandins Leukot Essent Fatty Acids. 1988;34: 27-30.
34. Hall LM, Murphy RC. Electrospray mass spectrometric analysis of 5-hydroperoxy and 5-hydroxyeicosatetraenoic acids generated by lipid peroxidation of red blood cell ghost phospholipids. J Am Soc Mass Spectrom. 1998;9:527-532.
35. Mencia-Huerta JM, Razin E, Ringel EW, et al. Immunologic and ionophore-induced generation of leukotriene B4 from mouse bone marrow-derived mast cells. J Immunol. 1983;130:1885-1890.
36. Stenke L, Lauren L, Reizenstein P, Lindgren JA. Leukotriene production by fresh human bone marrow cells: evidence of altered lipoxygenase activity in chronic myelocytic leukemia. Exp Hematol. 1987;15:203-207.
37. Zheng L, Du Y, Miller C, et al. Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia. 2007;50: 1987-1996.
38. Zheng L, Szabo C, Kern TS. Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-κB. Diabetes. 2004;53:2960-2967.
39. McMurdo L, Stephenson AH, Baldassare JJ, Sprague RS, Lonigro AJ. Biosynthesis of sulfidopeptide leukotrienes via the transfer of leukotriene A4 from polymorphonuclear cells to bovine retinal pericytes. J Pharmacol Exp Ther. 1998;285:1255-1259.