Divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention

Journal of Addictive Diseases

Volumn 21, Issue 2, 2002, Pages 55-64

  Longo, Lance P ^a   Campbell, Todd ^b   Hubatch, Sandra ^a  

^a AURORA SINAI MEDICAL CENTER   (United States)

^b MARQUETTE UNIVERSITY   (United States)

Author keywords

Alcohol dependence; Detoxification; Divalproex sodium; Withdrawal syndrome

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BENZODIAZEPINE; CHLORDIAZEPOXIDE; DISULFIRAM; LORAZEPAM; NALTREXONE; VALPROATE SEMISODIUM;

ADULT; ALCOHOL WITHDRAWAL; ARTICLE; ATAXIA; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DETOXIFICATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; MALE; NAUSEA; PSYCHOMOTOR DISORDER; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SYMPTOM; WITHDRAWAL SYNDROME;

ADULT; ALCOHOL WITHDRAWAL DELIRIUM; ALCOHOLISM; AMBULATORY CARE; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; CHLORDIAZEPOXIDE; FEMALE; FOLLOW-UP STUDIES; HUMANS; LORAZEPAM; MALE; MIDDLE AGED; PATIENT ADMISSION; PILOT PROJECTS; RECURRENCE; SUBSTANCE ABUSE TREATMENT CENTERS; TREATMENT OUTCOME; VALPROIC ACID;

EID: 0036402350     PISSN: 10550887     EISSN: None     Source Type: Journal    
DOI: 10.1300/J069v21n02_05     Document Type: Article

References (21)

1. Mayo-Smith MF. Pharmacological management of alcohol withdrawal: A meta analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. JAMA. 1997; 278: 144-51.
2. Longo LP, Johnson B. Benzodiazepines: Side effects, abuse risks, and alternatives. Am Fam Physician. 2000;61: 2121-8.
3. Roache JD, Meisch RA. Findings from self-administration research on the addiction potential of benzodiazepines. Psychiatric Annals. 1995; 25(3): 153-7.
4. Ciraulo DA, Sands BF, Shader RI. Critical review of liability for benzodiazepine abuse among alcoholics. Am J Psychiatry. 1988; 145: 1501-6.
5. Busto VE, Romach MK, Sellers EM. Multiple drug use and psychiatric comorbidity in patients admitted to the hospital with severe benzodiazepine dependence. J Clin Psychopharmacol. 1996; 16: 51-7.
6. Bursztajn HJ, Brodsky A. Ethical and legal dimensions of benzodiazepine prescription: A commentary. Psychiatric Annals. 1998: 28 (3): 121-8.
7. Prater CD, Miller KE, Zylstra RG. Outpatient detoxification of the addicted or alcoholic patient. Am Fam Physician. 1999; 60: 1175-83.
8. Anton RF, Myrick H. Clinical management of alcohol withdrawal. CNS Spectrums. 2000; 5(2): 22-32.
9. Malcohm R, Ballenger JC, Sturgis ET, Anton R. Double-blind controlled trial comparing carbamezepine to oxazepam treatment of alcohol withdrawal. Am J Drug Psychiatry. 1989; 146: 617-21.
10. Rosenthal RN, Perkel C, Singh P, et al. A pilot open randomized trial of Valproate and phenobarbital in the treatment of acute alcohol withdrawal. Am J Addictions. 1998; 7 (3): 189-97.
11. Myrick H, Brady KT, Malcolm R. Divalproex in the treatment of alcohol withdrawal. Am J Drug Alcohol Abuse. 2000, 26 (1): 155-60.
12. Minuk GY, Rockman GE, German GB et al. The use of sodium valproate in the treatment of alcoholism. J Addictive Dis. 1995; 14(2): 67-74.
13. Myrick H, Malcolm R. Gabapentin in the treatment of alcohol withdrawal (letter). Am J Psychiatry. 1998; 155: 1632.
14. Sussman N. (ed.) Anticonvulsants in Psychiatry. The Royal Society of Medicine Press, Ltd. Round Table Series 64. 1999.
15. Davis L, Ryan W, Adinoff B, Petty F. Comprehensive review of the psychiatric uses of valproate. J Clin Psychopharmacol. 2000; 20 (suppl 1): 1S-17S.
16. Wojnar M, Bizon Z, Wislewski D. Assessment of the role of kindling in the pathogenesis of alcohol withdrawal seizures and delirium tremens. Alcohol Clin Exp Res. 1999; 23: 204-8.
17. Hirschfield RM, Allen MH, McEvoy JP, Keck PE, Russell JM. Safety and tolerability of oral loading divalproex sodium in acutely manic bipolar patients. J Clin Psychiatry. 1999; 60: 815-8.
18. Longo LP. Non-benzodiazepine pharmacotherapy of anxiety and panic in substance abusing patients. Psychiatric Annals. 1998: 28 (3): 142-53.
19. Sullivan, JT, Sykora K, Schneiderman J, Narajo CA, Sellars EM. Assessment of alcohol withdrawal: The Revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-AR). Br J Addiction. 1989; 84:1353-7.
20. Croop RS, Faulkner EB, Labriola DF. The safety profile of naltrexone in the treatment of alcoholism. Results from a multicenter usage study. The Naltrexone Usage Study Group. Arch Gen Psychiatry. 1997; 54(12): 1130-5.]
21. Saxon AJ, Sloan KL, Reoux J, Haver VM. Disulfiram use in patients with abnormal liver function test results. J Clin Psychiatry. 1998; 59(6): 313-6.