Enantioselective pharmacokinetics of sibutramine in rat

Archives of Pharmacal Research

Volumn 33, Issue 2, 2010, Pages 267-273

  Noh, Keumhan ^a   Bae, Kyoungjin ^a   Min, Bokyoung ^a   Kim, Eunyoung ^b   Kwon, Kwang Il ^c   Jeong, Taecheon ^d   Kang, Wonku ^a  

^a Catholic University of Daegu   (South Korea)

^b Samsung Medical Center   (South Korea)

^c Chungnam National University   (South Korea)

^d Yeungnam University   (South Korea)

Author keywords

Didesmethylsibutramine; Enantioselective pharmacokinetics; Isomer; Monodesmethylsibutramine; Sibutramine

Indexed keywords

DINORSIBUTRAMINE; DRUG METABOLITE; MONONORSIBUTRAMINE; SIBUTRAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG TRANSFORMATION; DRUG URINE LEVEL; ENANTIOMER; ENANTIOSELECTIVITY; ISOMER; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CYCLOBUTANES; INJECTIONS, INTRAVENOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 77949885683     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-0212-7     Document Type: Article

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