Effects of clozapine on ethanol withdrawal syndrome in rats

Alcohol and Alcoholism

Volumn 43, Issue 6, 2008, Pages 619-625

  Kayir, Hakan ^a   Uzbay, Tayfun ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALCOHOL; CLOZAPINE;

AGITATION; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; BEHAVIOR CHANGE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG RESPONSE; HYPERACTIVITY; LOCOMOTION; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RIGIDITY; STEREOTYPY; TREMOR; WISTAR RAT;

ALCOHOL DRINKING; ANIMALS; CLOZAPINE; ETHANOL; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; STEREOTYPED BEHAVIOR; SUBSTANCE WITHDRAWAL SYNDROME;

CANIS FAMILIARIS; RATTUS; RATTUS NORVEGICUS;

EID: 55149085260     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agn052     Document Type: Article

References (57)

1. Alldredge BK. (1999) Seizure risk associated with psychotropic drugs: clinical and pharmacokinetic considerations. Neurol 53(Suppl 2): S68-75.
2. Alvir JM, Lieberman JA, Safferman AZ et al. (1993) Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med 329:162-7.
3. Ashby CR Jr, Wang, RY. (1996) Pharmacological actions of the atypical antipsychotic drug clozapine: A review. Synapse 24:349-94.
4. Baldessarini RJ, Centorrino F, Flood JG et al. (1993) Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology 9:117-24.
5. Batel P. (2000) Addiction and schizophrenia. Eur Psychiatry 15 115-22.
6. Brust JCM. (2004) Neurological Aspects of Substance Abuse, 2nd edn. Philadelphia: Elsevier Butterworth-Heinemann, 334.
7. Conroy SK, Rodd Z, Chambers RA. (2007) Ethanol sensitization in a neurodevelopmental lesion model of schizophrenia in rats. Pharmacol Biochem Behav 86:386-94.
8. Costall B, Domeney AM, Kelly ME et al. (1993) The effects of 5-HT3 receptor antagonists in models of dependency and withdrawal. Alcohol Alcohol 2(Suppl.):269-73.
9. Costall B, Naylor RJ, Tyers MB. (1990) The psychopharmacology of 5-HT3 receptors. Pharmacol Ther 47:181-202.
10. Dall'Olio R, Gandolfi O, Vaccheri A et al. (1988) Changes in behavioural responses to the combined administration of D1 and D2 dopamine agonists in normosensitive and D1 supersensitive rats. Psychopharmacology 95:381-5.
11. D'Souza DC, Gil RB, Madonick S et al. (2006) Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia. Neurupsychopharmacology 31:2767-75.
12. Drake RE, Xie H, McHugo GJ et al. (2000) The effects of clozapine on alcohol and drug use disorders among patients with schizophrenia. Schizophr Bull 26:441-9.
13. Fahlke C, Berggren U, Balldin J. (1999) Mental well-being in alcohol withdrawal: Relationship to alpha2-adrenoceptor function. Alcohol Alcohol 34:718-25.
14. Feldman DJ, Frank RA, Kehne JH et al. (1997) Mixed D2/5-HT2 antagonism differentially affects apomorphine- and amphetamine-induced stereotyped behavior. Pharmacol Biochem Behav 58:565-72.
15. Fone KC, Robinson AJ, Marsden CA. (1991) Characterization of the 5-HT receptor subtypes involved in the motor behaviours produced by intrathecal administration of 5-HT agonists in rats. Br J Pharmacol 103:1547-55.
16. Frye GD, McCown TJ, Breese GR. (1983) Differential sensitivity of ethanol withdrawal signs in the rat to gamma amino butyric acid (GABA) mimetics: Blockade of audiogenic seizures but not forelimb tremors. J Pharmacol Exp Ther 226:720-5.
17. Hambrecht M, Hafner H. (1996) Substance abuse and the onset of schizophrenia. Biol Psychiatry 40:1155-63.
18. Hauber W, Münkle M. (1997) Motor depressant effects mediated by dopamine D2 and adenosine A2 A receptors in the nucleus accumbens and the caudate-putamen. Eur J Pharmacol 323:127-31.
19. Hedges D, Jeppson K, Whitehead P. (2003) Antipsychotic medication and seizures: A review. Drugs Today 39:551-7.
20. Helzer D, Pryzbeck TR. (1988) The co-occurrence of alcoholism with other psychiatric disorders in the general population and its impact on treatment. J Stud Alcohol 49:219-24.
21. Hutchison KE, Wooden A, Swift RM et al. (2003) Olanzapine reduces craving for alcohol: A DRD4 VNTR polymorphism by pharmacotherapy interaction. Neuropsychopharmacology 28:1882-8.
22. Ingman K, Korpi ER. (2006) Alcohol drinking of alcohol-preferring AA rats is differentially affected by clozapine and olanzapine. Eur J Pharmacol 534:133-40.
23. Jaffe JH. (1990) Drug addiction and drug abuse. In Gilman AG, Rall, TW, Wies AS (eds). Goodman and Gilman's The Pharrmacological Basis of Therapeutics. New York: Pergamon, 522-73.
24. Kalkman HO, Neumann V, Hoyer D et al. (1998) The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat. Br J Pharmacol 124:1550-6.
25. Kuriyama K, Ohkuma S. (1990) Alterations in the function of cerebral neurotransmitter receptors during the establishment of alcohol dependence: Neurochemical aspects. Alcohol Alcohol 25:239-49.
26. Langosch JM, Trimble MR. (2002) Epilepsy, psychosis and clozapine. Hum Psychopharmacol 17:115-119.
27. Larue-Achagiotis C, Poussard AM, Louis-Sylvestre J. (1990) Alcohol drinking, food and fluid intakes and body weight gain in rats. Physiol Behav 47:545-8.
28. Longoni R, Spina L, Di Chiara G. (1987) Permissive role of D-1 receptor stimulation for the expression of D-2 mediated behavioral responses: A quantitative phenomenological study in rats. Life Sci 41 2135-45.
29. Magnusson O, Fowler CJ, Köhler C et al. (1986) Dopamine D2 receptors and dopamine metabolism. Relationship between biochemical and behavioural effects of substituted benzamide drugs. Neuropharmacology 25:187-97.
30. Majchrowicz E. (1975) Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia 43:1993-6.
31. Meltzer HY. (1994) An overview of the mechanism of action of clozapine. J Clin Psychiatry 55(Suppl. B):47-52.
32. Meltzer HY. (1997) Treatment-resistant schizophrenia: The role of clozapine. Curr Med Res Opin 14:1-20.
33. Miyamoto S, Duncan GE, Marx CE et al. (2005) Treatments for schizophrenia: A critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 10: 79-104.
34. Nutt D, Glue P, Molyneux S et al. (1988) Alpha-2-adrenoceptor function in alcohol withdrawal: A pilot study of the effects of iv clonidine in alcoholics and normals. Alcohol Clin Exp Res 12 14-8.
35. Parale MP, Kulkarni SK. (1986) Studies with alpha-2 adrenoceptor agonists and alcohol abstinence syndrome in rats. Psychopharmacology 88:237-9.
36. Potvin S, Stip E, Roy JY. (2003) Clozapine, quetiapine and olanzapine among addicted schizophrenic patients: Towards testable hypotheses. Int Clin Psychopharmacol 18:121-32.
37. Regier D, Farmer M, Rae D et al. (1990) Comorbidity of mental disorders with alcohol and other drug abuse. Results from the epidemiologic catchment area (ECA) study. J Am Med Assoc 264 2511-8.
38. Riihioja P, Jaatinen P, Oksanen H et al. (1997) Dexmedetomidine alleviates ethanol withdrawal symptoms in the rat. Alcohol 14 537-44.
39. Schatzberg AF, Cole JO, DeBattista C. (2003) Manual of Clinical Pharmacology, 4th edn. Washington, DC: American Psychiatric Publishing, 159-244.
40. Seeman P, Schwarz J, Chen JF et al. (2006) Psychosis pathways converge via D2 high dopamine receptors. Synapse 60:319-49.
41. Singhal SK, Zhang L, Morales M et al. (2007) Antipsychotic clozapine inhibits the function of a7-nicotinic acetylcholine receptors. Neuropharmacology 52:387-94.
42. Stefan M, Travis M, Murray RM (2002) An Atlas of Schizophrenia. London: The Parthenon Publishing Group, 74-7.
43. Svensson TH. (2003) Alpha-adrenoceptor modulation on hypothesis of antipsychotic activity. Prog Neuropsychopharmacol Biol Psychiatry 27:1145-58.
44. Takao K, Nagatani T, Kitamura Y et al. (1995) Chronic forced swim stress of rats increases frontal cortical 5-HT2 receptors and the wet-dog shakes they mediate, but not frontal cortical beta-adrenoceptors. Eur J Pharmacol 294:721-6.
45. Thrasher MJ, Freeman PA, Risinger FO. (1999) Clozapine's effects on ethanol's motivational properties. Alcohol Clin Exp Res 23 1377-85.
46. Unsalan, N., Saglam, E., Kayir, H et al. (2008) Effects of olanzapine on ethanol withdrawal syndrome in rats. Eur J Pharmacol 579:208-14.
47. Uzbay IT. (2008) Serotonergic antidepressants and ethanol withdrawal syndrome: A review. Alcohol Alcohol 43:15-24.
48. Uzbay IT, Akarsu ES, Kayaalp SO. (1994) Effects of bromocriptine and haloperidol on ethanol withdrawal syndrome in rats. Pharmacol Biochem Behav 49:969-74.
49. Uzbay IT, Erden BF, Tapanyiǧit EE et al. (1997) Nitric oxide synthase inhibition attenuates signs of ethanol withdrawal in rats. Life Sci 61:2197-209.
50. Uzbay IT, Kayaalp SO. (1995) A modified liquid diet of chronic ethanol administration: Validation by ethanol withdrawal syndrome in rats. Pharmacol Res 31:37-42.
51. Uzbay IT, Saglam E, Kayir H et al. (2004) Effects of fluoxetine on ethanol withdrawal syndrome in rats. J Psychiatr Res 38 445-50.
52. Uzbay IT, Usanmaz SE, Akarsu ES. (2000a) Effects of chronic ethanol administration on serotonin metabolism in the various regions of the rat brain. Neurochem Res 25:257-62.
53. Uzbay IT, Usanmaz SE, Tapanyigit EE et al. (1998) Dopaminergic and serotonergic alterations in the rat brain during ethanol withdrawal: association with behavioral signs. Drug Alcohol Depend 53 39-47.
54. Uzbay IT, Yesilyurt O, Celik T et al. (2000b) Effects of agmatine on ethanol withdrawal in rats. Behav Brain Res 107:153-9.
55. White DM, Van Cott AC. (2007) Clozapine (Clozaril), seizures, and EEG abnormalities. Am J Electroneurodiagnostic Technol 47:190-7.
56. Wong J, Delva N. (2007) Clozapine-induced seizures: Recognition and treatment. Can J Psychiatry 52:457-63.
57. Yap CY, Taylor DA. (1983) Involvement of 5-HT2 receptors in the wet-dog shake behaviour induced by 5-hydroxytryptophan in the rat. Neuropharmacology 22:801-4.