The role of doxycycline as a matrix metalloproteinase inhibitor for the treatment of chronic wounds

Biological Research for Nursing

Volumn 11, Issue 4, 2010, Pages 336-344

  Stechmiller, Joyce ^a   Cowan, Linda ^a   Schultz, Gregory ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Chronic wounds; Doxycycline; Inflammation; Metalloproteinase inhibitors

Indexed keywords

DOXYCYCLINE; MATRIX METALLOPROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; CHRONIC DISEASE; DRUG ANTAGONISM; HUMAN; INJURY;

CHRONIC DISEASE; DOXYCYCLINE; HUMANS; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; WOUNDS AND INJURIES;

EID: 77949807337     PISSN: 10998004     EISSN: 15524175     Source Type: Journal    
DOI: 10.1177/1099800409346333     Document Type: Article

References (65)

1. Agren, M.S. (1994). Gelatinase activity during wound healing. British Journal of Dermatology, 131, 634.
2. Armstrong, D.A., & Jude, E.B. (2002). The role of matrix metalloproteinases in wound healing. Journal of the American Podiatric Medical Association, 92, 12-18.
3. Assoian, R.K. (1997). Anchorage-dependent cell cycle progression. Journal of Cell Biology, 36, 1-4.
4. Barone, E.J., Yager, D.R., Pozez, A.L., Olutoye, O.O., Crossland, M.C., Diegelmann, R.F.,et al.(1998). Interleukin-1alpha and collagenase activity are elevated in chronic wounds. Plastic and Reconstructive Surgery, 102, 1023-1027.
5. Bartlett, J.D., Simmer, J.P., Xue, J., Margolis, H.C., & Morena, E.C. (1996). Molecular cloning and mRNA tissue distribution of a novel matrix metalloproteinase isolated from porcine enamel organ. Gene, 183, 123.
6. Bazzoni, F., & Beutler, B. (1996). The tumor necrosis factor ligand and receptor families. New England Journal of Medicine, 334, 117-125.
7. Birkedal-Hansen, H. (1995). Proteolytic remodeling of extracellular matrix. Current Opinion in Cell Biology, 7, 728.
8. Burns, F.R., Stack, M.S., Gray, R.D., & Paterson, C.A. (1989). Inhibition of purified collagenase from alkali-burned rabbit corneas. Investigative Ophthalmology and Visual Science, 30, 1569-1575.
9. Chang, K.M., Ramamurthy, N., McNamara, T.F., Evans, R.T., Klausen, B., Murray, P.A.,et al.(1994). Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism. Journal of Periodontal Research, 29, 242-249.
10. Chin, G.A., Thigpin, T.G., Perrin, K.J., Moldawer, L.L., & Schultz, G. (2003). Treatment of chronic ulcers in diabetic patients with a topical metalloproteinase inhibitor, doxycycline. Wounds, 15, 315-323.
11. Golub, L.M., McNamara, T.F., Ryan, M.E., Kohut, B., Flieden, T., Payonk, G.,et al.(2001). Adjunctive treatment with subantimicrobial doses of doxycycline: Effects on gingival fluid collagenase activity and attachment loss in adult periodontitis. Journal of Clinical Periodontology, 28, 146-156.
12. Golub, L.M., Sorsa, T., Lee, H.M., Ciancio, S., Sorbi, D., Ramamurthy, N.S.,et al.(1995). Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. Journal of Clinical Periodontology, 22, 100-109.
13. Grinnell, F., Ho, C.H., & Wysocki, A. (1996). Degradation of fibronectin and vitronectin in chronic wound fluid: Analysis by cell blotting, immunoblotting, and cell adhesion assays. Journal of Investigative Dermatology, 98, 410-416.
14. Grinnell, F., & Zhu, M. (1996). Fibronectin degradation in chronic wounds depends on the relative levels of elastase, a1-proteinase inhibitor, and a2-macroglbulin. Journal of Investigative Dermatology, 106, 335-341.
15. Lauhio, A., Konttinen, Y.T., Salo, T., Tschesche, H., Nordström, D., Lähdevirta, J.,et al.(1994). The in vivo effect of doxycycline treatment on matrix metalloproteinases in reactive arthritis. Annals of the New York Academy of Science, 732, 431-432.
16. Lee, H.M., Golub, L.M., Chan, D., Leung, M., Schroeder, K., Wolff, M.,et al.(1997). Alpha 1-proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: Serpinolytic inhibition by doxycycline. Journal of Periodontal Research, 32, 9-19.
17. Lindy, O., Konttinen, Y.T., Sorsa, T., Ding, Y., Santavirta, S., Ceponis, A.,et al.(1997). Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium. Arthritis Rheumatism, 40, 1391-1399.
18. Llano, E., Pendas, A.M., Knauper, V., Sorsa, T., Salo, T., Salido, E.,et al.(1997). Identification and structural and functional characterization of human enalmelysis (MMP-20). Biochemistry, 36, 15101.
19. Lobmann, R., Ambrosch, A., Schultz, G., Waldmann, K., Schiweck, S., & Lehnert, H. (2002). Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and nondiabetic patients. Diabetologia, 45, 1011-1016.
20. Mackelfresh, J., Soon, S., & Arbiser, J. (2005). Combination therapy of doxycycline and topical tacrolimus for venous ulcers. Archives of Dermatology, 141, 1476-1477.
21. Mast, B.A., & Schultz, G.S. (1996). Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Repair and Regeneration, 4, 411-420.
22. Medina, A., Scott, P., Ghahary, A., & Tredget, E. (2005). Pathophysiology of chronic nonhealing wounds. Journal of Burn Care & Rehabilitation, 26, 306-319.
23. Murphy, G. (1995). Matrix metalloproteinases and their inhibitors. Acta Orthopaedica Scandinavica Supplementum, 266, 55-60.
24. Murphy, G.J., Murphy, G., & Reynolds, J.J. (1991). The origin of matrix metalloproteinases and their familial relationships. FRBS Letters, 289, 4-7.
25. Murphy, G., & Nagase, H. (2008). Progress in matrix metalloproteinase research. Molecular Aspects of Medicine, 29, 290-308.
26. Murphy, G., & Willenbrock, F. (1995). Tissue inhibitors of matrix metalloendopeptidases. Methods in Enzymology, 248, 496-510.
27. Nagase, H., & Woessner, J.F. Jr. (1999). Matrix metalloproteinases. Journal of Biological Chemistry, 274, 21491-21494.
28. Nwomeh, B.C., Liang, H.X., Cohen, I.K., & Yager, D.R. (1999). MMP-8 is the predominant collagenase in healing wounds and non-healing ulcers. Journal of Surgical Research, 81, 189-195.
29. Nwomeh, B.C., Liang, H.X., Diegelmann, R.F., Cohen, I.K., & Yager, D.R. (1998). Dynamics of the matrix metalloproteinases MMP-1 and MMP-8 in acute open human dermal wounds. Wound Repair and Regeneration, 6, 127-134.
30. Nwomeh, B.C., Yager, D.R., & Cohen, I.K. (1998). Physiology of the chronic wound. Clinics in Plastic Surgery, 25, 341-356.
31. Parks, W. (1999). Matrix metalloproteinases in repair. Wound Repair and Regeneration, 7, 423-432.
32. Pendas, A.M., Knauper, V., Puente, X.S., Llano, E., Mattei, M.G., Apte, S.,et al.(1997). Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. Journal of Biological Chemistry, 272, 4281-4286.
33. Perry, H.D., & Golub, L.M. (1985). Systemic tetracyclines in the treatment of noninfected corneal ulcers: A case report and proposed new mechanism of action. Annals of Ophthalmology, 17, 742-744.
34. Pilcher, B.K., Gaither-Ganim, J., Parks, W.C., & Welgus, H.G. (1997). Cell type-specific inhibition of keratinocyte collagenase-1 expression by basic fibroblast growth factor and keratinocyte growth factor. A common receptor pathway. Journal of Biological Chemistry, 272, 18147-18154.
35. Pilcher, B.K., Wang, M., Quin, X.J., Parks, W.C., Senior, R.M., & Welgus, H.G. (1999). Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity. Annals of the New York Academy of Sciences, 878, 12-24.
36. Quantin, B., Murphy, G., & Breathnach, R. (1989). Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members. Biochemistry, 28, 5327-5334.
37. Ramamurthy, N.S., Jucine, A.J., McClain, S.A., McNamara, T.F., & Golub, L.M. (1998). Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin. Advances in Dental Research, 12, 144-148.
38. Sang, Q.X., Jin, Y., Newcomer, R., Monroe, S., Fang, X., Hurst, D.,et al.(2006). Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases. Current Topics in Medicinal Chemistry, 6, 289-316.
39. Savage, F.J., Lacombe, D.L., Boulos, P.B., & Hembry, R.M. (1997). Role of matrix metalloproteinases in healing of colonic anastomosis. Diseases of the Colon and Rectum, 40, 962-970.
40. Schultz, G.S., Chin, G.A., Moldawer, L., & Diegelmann, R.F. (2007). Wound care. In R. Fitridge & M. Thompson (Eds.), Mechanisms of vascular disease: A textbook for vascular surgeons (pp. 329-345). Cambridge, MA: Cambridge University Press.
41. Schultz, G.S., Strelow, S., Stern, G.A., Chegini, N., Grant, M.B., Galardy, R.E.,et al.(1992). Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Investigative Ophthalmology Visual Science, 33, 3325-3331.
42. Seedor, J.A., Perry, H.D., McNamara, T.F., Golub, L.M., Buxton, D.F., & Guthrie, D.S. (1987). Systemic tetracycline treatment of alkali-induced corneal ulceration in rabbits. Archives of Ophthalmology, 105, 268-271.
43. Shlopov, B.V., Smith, G.N. Jr., Cole, A.A., & Hasty, K.A. (1999). Differential patterns of response to doxycycline and transforming growth factor beta1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes. Arthritis & Rheumatism, 42, 719-727.
44. Siemonsma, M., de Hingh, I.H., de Man, B.M., Lomme, R.M., Verhofstad, A.A., & Hendriks, T. (2003). Doxycycline improves wound strength after intestinal anastomosis in the rat. Surgery, 133, 268-275.
45. Smith, G.N. Jr., Mickler, E.A., Hasty, K.A., & Brandt, K.D. (1999). Specificity of inhibition of matrix metalloproteinase activity by doxycycline: Relationship to structure of the enzyme. Arthritis & Rheumatism, 42, 1140-1146.
46. Soo, C., Hu, F.Y., Zhang, X., Wang, Y., Beanes, S.R., Lorenz, H.P.,et al.(2000). Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. American Journal of Pathology, 157, 423-433.
47. Stechmiller, J.K., Kilpadi, D., Childress, B., & Schultz, G. (2006). Effect of Vacuum-Assisted Closure Therapy on the expression of cytokines and proteases in wound fluid of adults with pressure ulcers. Wound Repair and Regeneration, 14, 371-374.
48. Stechmiller, J.K., & Schultz, G. (2008). Bench science advances for chronic wound care. In D. Krasner, G. Sibbal, & G. Rodeheaver (Eds.), Chronic wound care: A clinical source book for healthcare professionals. (4th ed.). King of Prussia, PA: Health Management Publications.
49. Sudbeck, B.D., Pilcher, B.K., Welgus, H.G., & Parks, W.C. (1997). Induction and repression of collagenase-1 by keratinocytes is controlled by distinct components of different extracellular matrix compartments. Journal of Biological Chemistry, 272, 22103-22110.
50. Suh, D.Y., & Hunt, T.K. (1998). Time line of wound healing. Clinics in Podiatric Medicine and Surgery, 15, 1-9.
51. Takino, T., Sato, H., Shinagawa, A., & Seiki, M. (1995). Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library: MT-MMPs form a unique membrane-type subclass in the MMP family. Journal of Biological Chemistry, 270, 23013-23020.
52. Tamargo, R.J., Bok, R.A., & Brem, H. (1991). Angiogenesis inhibition by minocycline. Cancer Research, 51, 672-675.
53. Tarnuzzer, R.W., & Schultz, G.S. (1996). Biochemical analysis of acute and chronic wound environments. Wound Repair and Regeneration, 4, 321-325.
54. Trengove, N.J., Bielefeldt-Ohmann, H., & Stacey, M.C. (2000). Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Wound Repair and Regeneration, 8, 13-25.
55. Trengove, N.J., Stacey, M.C., MacAuley, S., Bennett, N., Gibson, J., Burslem, F.,et al.(1999). Analysis of the acute and chronic wound environments: The role of proteases and their inhibitors. Wound Repair and Regeneration, 7, 442-452.
56. Trengove, N.J., Stacey, M.C., McGechie, D.F., & Mata, S. (1996). Qualitative bacteriology and leg ulcer healing. Journal of Wound Care, 5, 277-280.
57. Ueno, H., Nakamura, H., Inoue, M., Imai, K., Noguchi, M., Sato, H.,et al.(1997). Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Cancer Research, 57, 2055-2060.
58. van der Stappen, J.W., Hendriks, T., & de Boer, H.H. (1989). Collagenolytic activity extracted from intestinal anastomoses of the rat. Matrix, 9, 238-243.
59. Wall, S.J., Bevan, D., Thomas, D.W., Harding, K.G., Edwards, D.R., & Murphy, G. (2002). Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse. Journal of Investigative Dermatology, 119, 91-98.
60. Weckroth, M., Vaheri, A., Lauharanta, J., Sorsa, T., & Konttinen, Y.T. (1996). Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers. Journal of Investigative Dermatology, 106, 1119-1124.
61. Wysocki, A.B., & Grinnell, F. (1990). Fibronectin profiles in normal and chronic wound fluid. Laboratory Investigation, 63, 825-831.
62. Wysocki, A.B., Staiano-Coico, L., & Grinnell, F. (1993). Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. Journal of Investigative Dermatology, 101, 64-68.
63. Yager, D.R., & Nwomeh, B.C. (1999). The proteolytic environment of chronic wounds. Wound Repair and Regeneration, 7, 433-441.
64. Yager, D.R., Zhang, L.Y., Liang, H.X., Diegelmann, R.F., & Cohen, I.K. (1996). Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluid. Journal of Investigative Dermatology, 107, 743-748.
65. Yu, L.P. Jr., Smith, G.N. Jr., Hasty, K.A., & Brandt, K.D. (1991). Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase. Journal of Rheumatology, 18, 1450-1452.