α1-Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: Serpinolytic inhibition by doxycycline

Journal of Periodontal Research

Volumn 32, Issue 1 PART 1, 1997, Pages 9-19

  Lee, H M ^a   Golub, L M ^a   Chan, D ^a   Leung, M ^c   Schroeder, K ^d   Wolff, M ^a   Simon, S ^b   Crout, R ^d  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

^d WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Adult periodontitis; Doxycycline; Gingival crevicular fluid; 1 proteinase inhibitor

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTIINFECTIVE AGENT; COLLAGENASE; DOXYCYCLINE; LEUKOCYTE ELASTASE; TRYPSIN INHIBITOR;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; ENZYMOLOGY; FEMALE; GINGIVITIS; HUMAN; IMMUNOBLOTTING; MALE; METABOLISM; NEUTROPHIL; PERIODONTAL DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ADULT; ALPHA 1-ANTITRYPSIN; ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; COLLAGENASES; DOXYCYCLINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GINGIVAL CREVICULAR FLUID; HUMANS; IMMUNOBLOTTING; LEUKOCYTE ELASTASE; MALE; NEUTROPHILS; PERIODONTAL DISEASES; TRYPSIN INHIBITORS;

EID: 0030632754     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.1997.tb01377.x     Document Type: Article

References (56)

1. Janoff A, Scherer J. Mediators of inflammation in Neutrophil lysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 1968, 128: 1137-1151.
2. Murphy G, Bretz U, Baggiolini M, Reynolds JJ. The latent collagenase and gelatinase of human polymorphonuclear neutrophil leukocytes. Biochem J 1980; 192: 517-525.
3. Birkedal-Hansen H, Moore WGI, Bodden MK, et al. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 1993; 4: 197-250.
4. 1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis. J Periodontol 1994; 65: 702-709.
5. Armitage GC, Jeffcoat MK, Chadwick DE, et al. Longitudinal evaluation of elastase as a marker for the progression of periodontitis. J Periodontol 1994; 65: 120-128.
6. Palcanis KG, Larjava IK, Wells BR, et al. Elastase as an indicator of periodontal disease progression. J Periodontol 1992; 63: 237-242.
7. Sandholm L. Proteases and their inhibitors in chronic inflammatory periodontal disease. J Clin Periodontol 1986; 13: 19-26.
8. 1-antitrypsin-deficient individuals. J Clin Invest 1986; 77: 1952-1961.
9. 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes. EMBO J 1987; 6: 2767-2771.
10. 1-proteinase inhibitor binds to extracellular matrix in vitro with retention of inhibitory activity. Am J Respir Cell Mol Biol 1993; 9: 666-679.
11. Schenkein HA, Genco RJ. Gingival fluid and serum in periodontal diseases. Quantitative study of immunoglobulins, complement components, and other plasma proteins. J Periodontol 1977; 48: 772-777.
12. Giannopoulou C, Andersen E, Demeurisse C, Cimasoni G. Neutrophil elastase and its inhibitors in human gingival crevicular fluid during experimental gingivitis. J Dent Res 1992; 71: 359-363.
13. Janoff A. Elastases and emphysema: current assesment of the protease-antiprotease hypothesis. Am Rev Respir Dis 1985; 132: 417-433.
14. 1-Antitrypsin deficiency The metabolic basis of inherited disease. Scriver CR, Beaudet AL, Sly WS, Valle D, eds. New York: McGraw-Hill, 1989; 2409-2437.
15. 1-antitrypsin deficiency panniculitis. Acta Derm Venereal (Stockh) 1991; 71: 189-194.
16. 1-antitrypsin protease inhibitor system and periodontal bone loss. J Periodontol 1991; 62: 805.
17. Carp H, Janoff A. In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes. J Clin Invest 1979; 63: 793-797.
18. 1-proteinase inhibitor by human PMN leukocyte collagenase. FEBS Lett 1990; 263: 355-357.
19. 1-antitrypsin. Biochemistry 1990; 270: 809-814.
20. 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases. J Biol Chem 1992; 267: 5005-5012.
21. 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant. J Exp Med 1988; 167: 1608-1615.
22. 1-proteinase inhibitor on neutrophil chemotaxis. Am J Respir Cell Mol Biol 1990; 2: 163-170.
23. Golub LM, Lee HM, Lehrer G, et al. Minocycline reduces gingival collagenolytic activity during diabetes: preliminary observations and a proposed new mechanism of action. J Periodont Res 1983; 18: 516-526.
24. Golub LM, Wolff M, Lee HM, et al. Further evidence that tetracyclines inhibit collagenase activity in human crevicular fluid and from other mammalian sources. J Periodont Res 1985; 20: 12-23.
25. Golub LM, McNamara TF, D'Angelo G, Greenwald RA, Ramamurthy NS. A non-antibacterial chemically modified tetracycline inhibits mammalian collagenase activity. J Dent Res 1987; 66: 1310-1314.
26. Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991; 2: 297-322.
27. Rifkin BR, Vernillo AT, Golub LM. Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs. J Periodontol 1993; 64: 819-827.
28. 1-antitrypsin from human neutrophil collagenase and gelatinase. Antimicrob Agents Chemother 1993; 37: 592-594.
29. Golub LM, Ciancio S, Ramamurthy NS, Leung M, McNamara TF. Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans. J Periodont Res 1990; 25: 321-330.
30. Golub LM, Wolff M, Roberts S, Lee HM, Leung M, Payonk GS. Treating periodontal diseases by blocking tissue-destructive enzymes. JADA 1994; 125: 163-171.
31. Crout R, Lee HM, Schroeder K, et al. The cyclic regimen of low-dose doxycycline for adult periodontitis: a preliminary study. J Periodontol 1996; 67: 506-514.
32. Loe H, Silness P. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963; 21: 533-551.
33. Silness P, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964; 22: 121-135.
34. 3H-methyl] collagen. J Biochem Biophys Methods 1981; 5: 147-153.
35. Roscoe JT. Fundamental research statistics for behaviour science. New York: Holt, Rinehart and Winston, 1975; 309-350.
36. 1-proteinase inhibitor probes by limited proteolysis. Biochemistry 1992; 31: 2720-2728.
37. Golub LM, Sorsa T, Lee HM, et al. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodont 1995; 22: 100-109.
38. Adonogianaki E, Mooney J, Kinane DF. The ability of gingival crevicular fluid-acute phase proteins to distinguish health, gingivitis and periodontitis sites. J Clin Periodont 1992; 19: 98-102.
39. 2-macroglobulin in gingival crevicular fluid from patients with chronic adult periodontitis. Arch Oral Biol 1988; 33: 425-431.
40. 2-M in human gingiva: a study of the concentration of macro globulin and albumin in gingival fluid and serum. Arch Oral Biol 1990; 35: 13-16.
41. Shasby M. Antioxidant activity of some antiproteinases. Am Rev Respir Dis 1985; 131: 293-294.
42. 1-antitrypsin. FEBS Lett 1992; 300: 21-24.
43. Winyard PG, Zhang K, Chidwick DR, Blake RW, Carrell, Murphy G. Proteolytic inactivation of human alpha-1-antitrypsin by human stromelysin. FEBS Lett 1991; 279: 91-94.
44. Cimasoni G. Crevicular fluid updated. Monographs in oral science. Basel: Karger; 1983.
45. 2-macroglobulin synthesis in cultured human monocytes indicating inhibition of the terminal monocyte maturation into macrophages. Adv Exp Med Biol 1988; 240: 425-432.
46. Birrer P, McElvaney NG, Rudeberg A, et al. Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am J Respir Crit Care Med 1994; 150: 207-213.
47. Power C, O'Connor CM, MacFarlane D, et al. Neutrophil collagenase in sputum from patients with cystic fibrosis. Am J Respir Crit Care Med 1994; 150: 818-822.
48. Delacourt C, Bourgeois ML, D'Ortho M, et al. Imbalance between 95kDa type IV collagenase and tissue inhibitor of metalloproteinases in sputum of patients with cystic fibrosis. Am J Respir Crit Care Med 1995; 152: 765-774.
49. 1-antitrypsin. Biochem Biophy Res Commun 1994; 204: 613-620.
50. Golub LM, Evans RT, McNamara TF, Lee HM, Ramamurthy NS. A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats. Ann NY Acad Sci 1994; 732: 96-111.
51. Ryan ME, Ramamurthy NS, Golub LM. Matrix metalloproteinases and their inhibition in periodontal treatment. Curr Opin Periodontol 1996; 3: 85-96.
52. Weiss SJ. Tissue destruction by neutrophils. New Engl J Med 1989; 320: 365-376.
53. Wasil M, Halliwell BI, Moorhouse CP. Scavenging of hypochlorous acid by tetracycline, rifampicin and some other antibiotics: a possible antioxidant action of rifampicin and tetracycline. Biochem Pharmacol 1981; 37: 775-778.
54. Gabler WL, Creamer HC. Suppression of human neutrophil functions by tetracyclines. J Periodont Res 1991, 26: 52-58.
55. Ramamurthy NS, Vernillo AT, Greenwald RA, et al. Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase. J Bone Min Res 1993; 8: 1247-1253.
56. 2-macroglobulin by neutrophils and eosinophils. J Biol Chem 1989; 264: 13801-13809.