TLR3c. 1377, TLR9 -1486, and TLR9 2848 gene polymorphisms and multiple sclerosis

Journal of Central South University (Medical Sciences)

Volumn 35, Issue 2, 2010, Pages 116-122

  Ji, Xiaobei ^a   Wang, Yuzhong ^a   Huang, Guoxiang ^a   Zhou, Wenbin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Multiple sclerosis; Single nucleotide polymorphism; Toll like receptor

Indexed keywords

TLR3 PROTEIN, HUMAN; TLR9 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 9;

ADOLESCENT; ADULT; AGED; ARTICLE; ASIAN; CHILD; CHINA; ETHNOLOGY; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS;

ADOLESCENT; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; CHINA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; POLYMORPHISM, GENETIC; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 9; YOUNG ADULT;

EID: 77949783429     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1672-7347.2010.02.005     Document Type: Article

References (15)

1. Sun J, Walsh M, Villarino A V, et al. TLR ligands can activate dendritic cells to provide a MyD88 -dependent negative signal for Th2 cell development [J]. J Immnol, 2005 , 174(2) : 742-751.
2. Takeda K, Kaisho T, Akira S. Toll-like receptors [ J ]. Annu Rev Immunol, 2003 , 21(4) : 335-376.
3. Lafon M , Megret F, Lafage M, et al. The innate immune facet of brain: human neurons express TLR -3 and sense viral dsRNA[J]. J Mol Neurosci, 2006, 29(3): 185-194.
4. + T cells by Toll-like receptor 3-activated human microglia [ J ] . J Neuropathol Exp Neurol, 2007 , 66 ( 9 ): 848-859.
5. Ichikawa H T , Williams L P , Segal B M. Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease [J]. J Immunol, 2002, 169(5): 2781-2787.
6. Raimondi G, Turner M S, Thomson A W, et al. Naturally occurring regulatory T cells : recent insights in health and disease [ J ] . Crit Rev Immunol, 2007 , 27 ( 1 ): 61-95.
7. Prinz M, Garbe F, Schmidt H, et al. Innate immunity mediated by TLR 9 modulates pathogenicity in an animal model of multiple sclerosis [ J ] . J Clin Invest, 2006, 116(2): 454-464.
8. Smit L A, Siroux V, Bouzigon E, et al. CD14 and tolllike receptor gene polymorphisms , country living , and asthma in adults [J]. Am J Respir Crit Care Med, 2009 , 179 (5): 363-368.
9. Polman C H, Reingold S C, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the " McDonald Criteria" [J]. Ann Neurol, 2005, 58(6): 840-846.
10. Ueta M , Sotozono C, Inatomi T, et al. Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome [J]. Br J Ophthalmol, 2007, 91(7): 962-965.
11. De Jager P L, Richardson A, Vyse T J, et al. Genetic variation in Toll-like receptor 9 and susceptibility to systemic lupus erythematosus [J]. Arthritis Rheum , 2006 , 54(4): 1279-1282.
12. Kikuchi K, Lian Z X , Kimura Y, et al. Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis[J]. J Autoimmun, 2005, 24(4): 347-352.
13. Epplen C, Jackel S, Santos E J, et al. Genetic predisposition to multiple sclerosis as revealed by immunoprinting [J]. Ann Neurol, 1997 , 41 ( 3 ): 341-352.
14. Wandstrat A, Wakeland E. The genetics of complex autoimmune diseases : non - MHC susceptibility genes [J]. Nat Immunol, 2001 , 2(9): 802-809.
15. Hur J W, Shin H D, Park B L, et al. Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus [J]. Antigens , 2005 , 65(3): 266-270.