-
2
-
-
17744418769
-
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
-
Steinbach G, Lynch PM, Phillips RKS, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 2000;342:1946-52.
-
(2000)
N Engl J Med
, vol.342
, pp. 1946-1952
-
-
Steinbach, G.1
Lynch, P.M.2
Phillips, R.K.S.3
-
3
-
-
33748180713
-
Celecoxib for the prevention of colorectal adenomatous polyps
-
Arber N, Eagle CJ, Spicak J, et al. Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med 2006;355: 885-95.
-
(2006)
N Engl J Med
, vol.355
, pp. 885-895
-
-
Arber, N.1
Eagle, C.J.2
Spicak, J.3
-
4
-
-
34247272614
-
Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: Two steps forward, one step back
-
Bertagnolli MM. Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back. Lancet Oncol 2007;8:439-43.
-
(2007)
Lancet Oncol
, vol.8
, pp. 439-443
-
-
Bertagnolli, M.M.1
-
5
-
-
20144365496
-
Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention
-
Solomon SD, McMurray JJ, Pfeffer MA, et al. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med 2005;352:1071-80.
-
(2005)
N Engl J Med
, vol.352
, pp. 1071-1080
-
-
Solomon, S.D.1
McMurray, J.J.2
Pfeffer, M.A.3
-
6
-
-
19744380776
-
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
-
Bresalier RS, Sandler RS, Quan H, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2005;352:1092-102.
-
(2005)
N Engl J Med
, vol.352
, pp. 1092-1102
-
-
Bresalier, R.S.1
Sandler, R.S.2
Quan, H.3
-
7
-
-
33745728135
-
Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2-inhibitor
-
Carothers AM, Moran AE, Cho NL, Redston M, Bertagnolli MM. Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2-inhibitor. Cancer Res 2006;66:6432-8.
-
(2006)
Cancer Res
, vol.66
, pp. 6432-6438
-
-
Carothers, A.M.1
Moran, A.E.2
Cho, N.L.3
Redston, M.4
Bertagnolli, M.M.5
-
8
-
-
0034796261
-
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc (△716) knockout mice
-
Sonoshita M, Takaku K, Sasaki N, et al. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc (△716) knockout mice. Nat Med 2001;7:1048-51.
-
(2001)
Nat Med
, vol.7
, pp. 1048-1051
-
-
Sonoshita, M.1
Takaku, K.2
Sasaki, N.3
-
9
-
-
21744453780
-
Epthelial cells and their neighbors: I. Role of intestinal myofibroblasts in development, repair, and cancer
-
Powell DW, Adegboyege PA, Di Mari JF, Mifflin RC. Epthelial cells and their neighbors: I. Role of intestinal myofibroblasts in development, repair, and cancer. Am J Physiol 2005;289:G2-7.
-
(2005)
Am J Physiol
, vol.289
-
-
Powell, D.W.1
Adegboyege, P.A.2
Di Mari, J.F.3
Mifflin, R.C.4
-
11
-
-
1542269250
-
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
-
Takeda H, Miyoshi H, Tamai Y, Oshima M, Taketo MM. Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. Br J Cancer 2004;90:701-4.
-
(2004)
Br J Cancer
, vol.90
, pp. 701-704
-
-
Takeda, H.1
Miyoshi, H.2
Tamai, Y.3
Oshima, M.4
Taketo, M.M.5
-
12
-
-
0028803728
-
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
-
Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 1995;493-501.
-
(1995)
Cell
, pp. 493-501
-
-
Tsujii, M.1
DuBois, R.N.2
-
13
-
-
36148989932
-
Cyclooxygenase 2 overexpression abrogates the antiproliferative effects of TGF-β
-
Enders G. Cyclooxygenase 2 overexpression abrogates the antiproliferative effects of TGF-β. Br J Cancer 2007;7:1388-92.
-
(2007)
Br J Cancer
, vol.7
, pp. 1388-1392
-
-
Enders, G.1
-
14
-
-
33845334175
-
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
-
Pardali K, Moustakas A. Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta 2007; 1775:21-62.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 21-62
-
-
Pardali, K.1
Moustakas, A.2
-
16
-
-
0032544448
-
Smad3 mutant mice develop metastatic colorectal cancer
-
Zhu Y, Richardson J, Parada L, Graff J. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998;703-14.
-
(1998)
Cell
, pp. 703-714
-
-
Zhu, Y.1
Richardson, J.2
Parada, L.3
Graff, J.4
-
18
-
-
0036277026
-
Myofibroblasts and mechano-regulation of connective tissue remodeling
-
Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodeling. Nat Rev Mol Cell Biol 2002;3:349-63.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 349-363
-
-
Tomasek, J.J.1
Gabbiani, G.2
Hinz, B.3
Chaponnier, C.4
Brown, R.A.5
-
19
-
-
0032527902
-
Mutation of the type II transforming growth factor β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas
-
Grady W, Rajput A, Meyeroff L, et al. Mutation of the type II transforming growth factor β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res 1998;58:3101-4.
-
(1998)
Cancer Res
, vol.58
, pp. 3101-3104
-
-
Grady, W.1
Rajput, A.2
Meyeroff, L.3
-
20
-
-
0036073299
-
Differential expression of TGFβ isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
-
McKaig BC, Hughes K, Tighe PJ, Mahida TR. Differential expression of TGFβ isoforms by normal and inflammatory bowel disease intestinal myofibroblasts. Am J Physiol 2002;C172-82.
-
(2002)
Am J Physiol
-
-
McKaig, B.C.1
Hughes, K.2
Tighe, P.J.3
Mahida, T.R.4
-
21
-
-
66649106333
-
Transforming growth factor-β signaling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures
-
Di Sabatino A, Jackson CL, Pickard KM, et al. Transforming growth factor-β signaling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut 2009;58:777-89.
-
(2009)
Gut
, vol.58
, pp. 777-789
-
-
Di Sabatino, A.1
Jackson, C.L.2
Pickard, K.M.3
-
23
-
-
47549100061
-
Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: An immunohistochemical study of clinically annotated tumors
-
Hashimoto Y, Skacel M, Adams JC. Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: an immunohistochemical study of clinically annotated tumors. BMC Cancer 2008;8:185.
-
(2008)
BMC Cancer
, vol.8
, pp. 185
-
-
Hashimoto, Y.1
Skacel, M.2
Adams, J.C.3
-
24
-
-
0033934447
-
Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice
-
Alexander CM, Reichsman F, Hinkes MT, et al. Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice. Nat Genet 2000;25:329-32.
-
(2000)
Nat Genet
, vol.25
, pp. 329-332
-
-
Alexander, C.M.1
Reichsman, F.2
Hinkes, M.T.3
-
25
-
-
34548844181
-
Potential role of heparan sulfate proteoglycans in regulation of transforming growth factor-β (TGF-β) bymodulating assembly of latent TGF-β-binding protein-1
-
Chen Q, Sivakumar P, Barley C, Peters DM, Gomes RR, Farach-Carson MC. Potential role of heparan sulfate proteoglycans in regulation of transforming growth factor-β (TGF-β) bymodulating assembly of latent TGF-β-binding protein-1. J Biol Chem 2007;282:26418-30.
-
(2007)
J Biol Chem
, vol.282
, pp. 26418-26430
-
-
Chen, Q.1
Sivakumar, P.2
Barley, C.3
Peters, D.M.4
Gomes, R.R.5
Farach-Carson, M.C.6
-
26
-
-
38149103259
-
Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function
-
Bode L, Salvestrini C, Park PW, et al. Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest 2008;118:229-38.
-
(2008)
J Clin Invest
, vol.118
, pp. 229-238
-
-
Bode, L.1
Salvestrini, C.2
Park, P.W.3
-
27
-
-
0034695918
-
Shedding of syndecan-1 and -1 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase
-
Fitzgerald ML, Wang Z, Park PW, Murphy G, Bernfield M. Shedding of syndecan-1 and -1 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase. J Cell Biol 2000;148:811-24.
-
(2000)
J Cell Biol
, vol.148
, pp. 811-824
-
-
Fitzgerald, M.L.1
Wang, Z.2
Park, P.W.3
Murphy, G.4
Bernfield, M.5
-
28
-
-
63649101805
-
Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis
-
Kliment CR, Englert JM, Gouchuico BR, et al. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. J Biol Chem 2009;284:3537-45.
-
(2009)
J Biol Chem
, vol.284
, pp. 3537-3545
-
-
Kliment, C.R.1
Englert, J.M.2
Gouchuico, B.R.3
-
29
-
-
34250366643
-
Heparanase enhances syndecan-1 shedding: A novel mechanism for stimulation of tumor growth and metastasis
-
Yang Y, MacLeod V, Miao H-Q, et al. Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis. J Biol Chem 2007;282:13326-33.
-
(2007)
J Biol Chem
, vol.282
, pp. 13326-13333
-
-
Yang, Y.1
MacLeod, V.2
Miao, H.-Q.3
-
30
-
-
33845684922
-
Heparanase upregulation by colonic epithelium in inflammatory bowel disease
-
Waterman M, Ben-Izhak O, Eliakim R, Groisman G, Vlodavsky I, Ilan N. Heparanase upregulation by colonic epithelium in inflammatory bowel disease. Mod Pathol 2007;20:8-14.
-
(2007)
Mod Pathol
, vol.20
, pp. 8-14
-
-
Waterman, M.1
Ben-Izhak, O.2
Eliakim, R.3
Groisman, G.4
Vlodavsky, I.5
Ilan, N.6
-
31
-
-
0035914414
-
Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice
-
Carothers AM, Melstrom KAJ, Mueller JD, Weyant MJ, Bertagnolli MM. Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice. J Biol Chem 2001; 276:39094-102.
-
(2001)
J Biol Chem
, vol.276
, pp. 39094-39102
-
-
Carothers, A.M.1
Melstrom, K.A.J.2
Mueller, J.D.3
Weyant, M.J.4
Bertagnolli, M.M.5
-
32
-
-
34547960749
-
The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses
-
Bellin A, Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 2007;87:858-70.
-
(2007)
Lab Invest
, vol.87
, pp. 858-870
-
-
Bellin, A.1
Mattoli, S.2
-
33
-
-
0029144854
-
Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinoma
-
Pyke C, Salo S, Ralfkiaer E, Romer J, Dano K, Tryggvason K. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinoma. Cancer Res 1995;55:4132-9.
-
(1995)
Cancer Res
, vol.55
, pp. 4132-4139
-
-
Pyke, C.1
Salo, S.2
Ralfkiaer, E.3
Romer, J.4
Dano, K.5
Tryggvason, K.6
-
34
-
-
33748196958
-
A randomized trial of celecoxib to prevent sporadic colorectal adenomas
-
Bertagnolli MM, Eagle CJ, Zauber AG, et al. A randomized trial of celecoxib to prevent sporadic colorectal adenomas. N Engl J Med 2006;355:873-84.
-
(2006)
N Engl J Med
, vol.355
, pp. 873-884
-
-
Bertagnolli, M.M.1
Eagle, C.J.2
Zauber, A.G.3
-
35
-
-
57249089705
-
Aberrant crypt foci in the Adenoma Prevention with Celecoxib (APC) Trial
-
Cho NL, Zauber A, Redston M, et al. Aberrant crypt foci in the Adenoma Prevention with Celecoxib (APC) Trial. Cancer Prev Res 2008;1:21-31.
-
(2008)
Cancer Prev Res
, vol.1
, pp. 21-31
-
-
Cho, N.L.1
Zauber, A.2
Redston, M.3
-
36
-
-
22544475938
-
Prostaglandin E2 stimulates the β-catenin/T cell factor-dependent transcription in colon cancer
-
Shao J, Jung C, Liu C, Sheng H. Prostaglandin E2 stimulates the β-catenin/T cell factor-dependent transcription in colon cancer. J Biol Chem 2005;280:26565-72.
-
(2005)
J Biol Chem
, vol.280
, pp. 26565-26572
-
-
Shao, J.1
Jung, C.2
Liu, C.3
Sheng, H.4
-
37
-
-
5644289372
-
Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice
-
Moran AE, Hunt DH, Javid SH, Redston M, Carothers AM, Bertagnolli MM. Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. J Biol Chem 2004;43261-72.
-
(2004)
J Biol Chem
, pp. 43261-43272
-
-
Moran, A.E.1
Hunt, D.H.2
Javid, S.H.3
Redston, M.4
Carothers, A.M.5
Bertagnolli, M.M.6
-
38
-
-
59149102643
-
Lkb1 is required for TGFβ-mediated myofibroblast differentiation
-
Vaahtomeri K, Ventelä E, Laajanen K, et al. Lkb1 is required for TGFβ-mediated myofibroblast differentiation. J Cell Sci 2008;121: 3531-40.
-
(2008)
J Cell Sci
, vol.121
, pp. 3531-3540
-
-
Vaahtomeri, K.1
Ventelä, E.2
Laajanen, K.3
-
39
-
-
27744577296
-
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
-
Shim J-H, Xiao C, Paschal AE, et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 2005;19:2668-81.
-
(2005)
Genes Dev
, vol.19
, pp. 2668-2681
-
-
Shim, J.-H.1
Xiao, C.2
Paschal, A.E.3
-
40
-
-
34248384441
-
Dose-dependent crosstalk between the transforming growth factor-β and interleukin-1 signaling pathways
-
Lu T, Tian L, Han Y, Vogelbaum M, Stark GR. Dose-dependent crosstalk between the transforming growth factor-β and interleukin-1 signaling pathways. Proc Natl Acad Sci U S A 2007;104:4365-70.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 4365-4370
-
-
Lu, T.1
Tian, L.2
Han, Y.3
Vogelbaum, M.4
Stark, G.R.5
-
41
-
-
34548225362
-
NF-κβ is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of IKKβ
-
Greten FR, Arkan MC, Bollrath J, et al. NF-κβ is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of IKKβ. Cell 2007;130:918-31.
-
(2007)
Cell
, vol.130
, pp. 918-931
-
-
Greten, F.R.1
Arkan, M.C.2
Bollrath, J.3
-
42
-
-
13444257363
-
Carnosol inhibits β-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J-Min/+ (Min/+) mouse
-
Moran AE, Carothers AM, Weyant MJ, Redston M, Bertagnolli MM. Carnosol inhibits β-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J-Min/+ (Min/+) mouse. Cancer Res 2005;65:1097-104.
-
(2005)
Cancer Res
, vol.65
, pp. 1097-1104
-
-
Moran, A.E.1
Carothers, A.M.2
Weyant, M.J.3
Redston, M.4
Bertagnolli, M.M.5
|