Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients

Anaesthesia and Intensive Care

Volumn 38, Issue 2, 2010, Pages 307-316

  Zeden, J P ^a   Fusch, G ^a,b   Holtfreter, B ^a   Schefold, J C ^a,c   Reinke, P ^a,c   Domanska, G ^a   Haas, J P ^a,b   Gruendling, M ^a,b   Westerholt, A ^a,b   Schuett, C ^a,b  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Immunosuppression; Indoleamine 2,3 dioxygenase; Infection; Intensive care unit; Kynurenine; Quinolinic acid

Indexed keywords

HYPERTENSIVE AGENT; KYNURENIC ACID; KYNURENINE; NORADRENALIN; QUINOLINIC ACID; SEROTONIN; TRYPTOPHAN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIAGNOSTIC VALUE; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; FLUID RESUSCITATION; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; KIDNEY CLEARANCE; KIDNEY FAILURE; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PATIENT MONITORING; PROSPECTIVE STUDY; SEPSIS; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SURGICAL WARD; TANDEM MASS SPECTROMETRY; TRYPTOPHAN METABOLISM;

EID: 77949745005     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x1003800213     Document Type: Article

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