Increased plasma kynurenine values and kynurenine-tryptophan ratios after major trauma are early indicators for the development of sepsis

Shock

Volumn 32, Issue 1, 2009, Pages 29-34

  Lögters, Tim T ^a   Laryea, Maurice D ^a   Altrichter, Jens ^a   Sokolowski, Janina ^a   Cinatl, Jindrich ^b   Reipen, Jenny ^a   Linhart, Wolfgang ^a   Windolf, Joachim ^a   Scholz, Martin ^a   Wild, Michael ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Kynurenine; Multiple organ failure; Sepsis; Trauma; Tryptophan

Indexed keywords

KYNURENINE; TRYPTOPHAN;

ABDOMINAL INJURY; ADOLESCENT; ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; BRAIN INJURY; CONTROLLED STUDY; CORRELATIONAL STUDY; DEATH; DISEASE COURSE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOSPITAL ADMISSION; HUMAN; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; SEPSIS; THORAX INJURY;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; INJURY SEVERITY SCORE; KINETICS; KYNURENINE; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; SEPSIS; TIME FACTORS; TRYPTOPHAN; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 67749144008     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31819714fa     Document Type: Article

References (35)

1. Bozza S, Fallarino F, Pitzurra L, Zelante T, Montagnoli C, Bellocchio S, Mosci P, Vacca C, Puccetti P, Romani L: A crucial role for tryptophan catabolism at the host/Candida albicans interface. J Immunol 174:2910-2918, 2005.
2. Brown RR, Ozaki Y, Datta SP, Borden EC, Sondel PM, Malone DG: Implications of interferon-induced tryptophan catabolism in cancer, autoimmune diseases and AIDS. Adv Exp Med Biol 294:425-435, 1991.
3. Mellor AL, Munn DH: IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4:762-774, 2004.
4. Moffett JR, Namboodiri MA: Tryptophan and the immune response. Immunol Cell Biol 81:247-265, 2003.
5. Sas K, Robotka H, Toldi J, Vécsei L: Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders. J Neurol Sci 257:221-239, 2007.
6. Taylor MW, Feng GS: Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 5:2516-2522, 1991.
7. Mulley WR, Nikolic-Paterson DJ: Indoleamine 2,3-dioxygenase in transplantation. Nephrology 13:204-211, 2008.
8. Pfefferkorn ER: Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci U S A 81:908-912, 1984.
9. Yoshida R, Oku T, Imanishi J, Kishida T, Hayaishi O: Interferon: a mediator of indoleamine 2,3-dioxygenase induction by lipopolysaccharide, poly (I), X poly (C), and pokeweed mitogen in mouse lung. Arch Biochem Biophys 249: 596-604, 1986.
10. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL: Prevention of allogenic fetal rejection by tryptophan catabolism. Science 281:1191-1193, 1998.
11. Mackay GM, Forrest CM, Stoy N, Christofides J, Egerton M, Stone TW, Darlington LG: Tryptophan metabolism and oxidative stress in patients with chronic brain injury. Eur J Neurology 13:30-42, 2006.
12. Pellegrin K, Neurauter G, Wirleitner B, Fleming AW, Peterson VM, Fuchs D: Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma. Shock 23:209-215, 2005.
13. Kwidzinski E, Bechmann I: IDO expression in the brain: a double-edged sword. J Mol Med 85:1351-1359, 2007.
14. Schwarcz R, Whetsell WO Jr, Mangano RM: Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219: 316-318, 1983.
15. Smith AJ, Stone TW, Smith RA: Neurotoxicity of tryptophan metabolites. Biochem Soc Trans 35:1287-1289, 2007.
16. Mole DJ, McFerran NV, Collett G, O'Neill CO, Diamond T, Garden OJ, Kylanpaa L, Repo H, Deitch EA: Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure. Br J Surg 95:855-867, 2008.
17. Greenspan L, McLellan BA, Greig H: Abbreviated Injury Scale and Injury Severity Score: a scoring chart. J Trauma 25:60-64, 1985.
18. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29:530-538, 2003.
19. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ: Multiple Organ Dysfunction Score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23:1638-1652, 1995.
20. Widner B, Werner ER, Schennach H, Wachter H, Fuchs D: Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem 43: 2424-2426, 1997.
21. Margraf S, Lögters T, Reipen J, Altrichter J, Scholz M, Windolf J: Neutrophilderived circulating free DNA (cf-DNA/NETs), a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis. Shock 30:352-358, 2008.
22. Meisner M, Adina H, Schmidt J: Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients. Crit Care 10:R1, 2006.
23. Puccetti P, Grohmann U: IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation. Nat Rev Immunol 7: 817-823, 2007.
24. Romani L, Fallarino F, De Luca A, Montagnoli C, D'Angelo C, Zelante T, Vacca C, Bistoni F, Fioretti MC, Grohmann Z, et al.: Detective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 451:211-215, 2008.
25. Moore FA, Moore EE, Jones TN, McCroskey BL, Peterson VM: TEN versus TPN following major abdominal trauma reduced septic morbidity. J Trauma 29:916-922, 1989.
26. Scholz M, Cinatl J, Schädel-Höpfner M, Windolf J: Neutrophils and the bloodbrain barrier dysfunction after trauma. Med Res Rev 27:401-416, 2007.
27. Hietbrink F, Koenderman L, Rijkers G, Leenen L: Trauma: the role of the innate immune system. World J Emerg Surg 20:1-15, 2006.
28. Keel M, Trentz O: Pathophysiology of polytrauma. Injury 36:691-709, 2005.
29. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 348:138-150, 2003.
30. Pillay J, Hietbrink F, Koenderman L, Leenen LP: The systemic inflammatory response induced by trauma is reflected by multiple phenotypes of blood neutrophils. Injury 38:1365-1372, 2007.
31. Seitz DH, Perl M, Mangold S, Neddermann A, Braumüller ST, Zhou S, Bachem MG, Huber-Lang MS, Knöferl MW: Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils. Shock 30:537-544, 2008.
32. Heseler K, Spekker K, Schmidt SK, MacKenzie CR, Däubener W: Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-gammaYinduced tryptophan degradation. FEMS Immunol Med Microbiol 52:273-281, 2008.
33. Lendemans S, Kreuzfelder E, Waydhas C, Schade FU, Flohé S: Differential immunostimulating effect of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and interferon gamma (IFNgamma) after severe trauma. Inflamm Res 56:38-44, 2007.
34. Madihally SV, Toner M, Yarmush ML, Mitchell RN: Interferon gamma modulates trauma-induced muscle wasting and immune dysfunction. Ann Surg 236:649-657, 2002.
35. McDaniel DO, Hamilton J, Brock M, May W, Calcote L, Tee LY, Vick L, Newman DB, Vick K, Harrison S, et al.: Molecular analysis of inflammatory markers in trauma patients at risk of postinjury complications. J Trauma 63:147-157, 2007.