Physiopathology of melasma;Fisiopatologia do melasma

Anais Brasileiros de Dermatologia

Volumn 84, Issue 6, 2009, Pages 623-635

  Miot, Luciane Donida Bartoli ^a   Miot, Hélio Amante ^a   Da Silva, Márcia Guimarães ^a   Marques, Mariângela Esther Alencar ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Melanosis; Pigmentation disorders; Skin pigmentation; Ultraviolet rays

Indexed keywords

COSMETIC;

CHLOASMA; ENDOCRINE DISEASE; HEREDITY; HUMAN; HYPERPIGMENTATION; MELANOCYTE; MELANOSIS; REVIEW; SUN EXPOSURE; ULTRAVIOLET RADIATION;

HUMANS; MELANOSIS;

EID: 77949691097     PISSN: 03650596     EISSN: 18064841     Source Type: Journal    
DOI: 10.1590/S0365-05962009000600008     Document Type: Review

References (94)

1. Costin GE, Hearing VJ. Human skin pigmentation: melanocytes modulate skin color in response to stress. Faseb J. 2007;2:976-94.
2. Miot LDB, Miot HA, Silva MG, Marques MEA. Estudo comparativo morfofuncional de melanócitos em lesões de melasma. An Bras Dermatol. 2007;82:529-64.
3. Sulem P, Gudbjartsson DF, Stacey SN, Helgason A, Rafnar T, Magnusson KP, et al. Genetic determinants of hair, eye and skin pigmentation in Europeans. Nat Genet. 2007;39:1443-52.
4. Ortonne JP [homepage on the Internet]. Skin color variations in humankind: an explanation? Nice: Pigmentary Disorders Academy; 2005 [cited 2009 Jun 23]. Available from: http://www.pigmentarydisordersacademy.org/guest- editorials-ortonne-skincolor.jsp.
5. Jablonski NG, Chaplin G. The evolution of human skin coloration. J Hum Evol. 2000;39:57-106.
6. Relethford JH. Hemispheric difference in human skin color. Am J Phys Anthropol.1997;104:449-57.
7. Mosher DB, Fitzpatrick TB, Ortonne JP, Hori Y. Normal skin color and General Considerations of Pigmentary Disorders. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF. Dermatology in General Medicine. v. 1. New York: Mcgraw-Hill; 1999. p. 936-44.
8. Sulaimon SS, Kitchell BE. The biology of melanocytes. Vet Dermatol. 2003;14: 57-65.
9. Lin JY, Fisher DE. Melanocyte biology and skin pigmentation. Nature. 2007; 445:843-50.
10. Abdel-Malek ZA, Scott MC, Furumura M, et al. The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes. J Cell Sci. 2001;114:1019-24.
11. Jimbow K, Quevedo Jr WC, Fitzpatrick TB et al. Biology of Melanocytes. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF. Dermatology in General Medicine. v. 1. New York: Mcgraw-Hill; 1999. p.192-220.
12. Boissy RE. The melanocyte. Its structure, function, and subpopulations in skin, eyes, and hair. Dermatol Clin. 1988;6:161-73.
13. Bleehen SS, Ebling FJG, Champion RH. Disorders of Skin Color. In: Champion RH, Burton JL, Ebling FJG. Eds Rook / Wilkinson / Ebling textbook of Dermatology. v. 2. Oxford: Blackwell Scientific publications; 1992. p.1561-2.
14. Storm CA, Elder DE. Pele. In: Rubin E, Gorstein F, Rubin R, Scwarting R, Strayer D. Patologia: Bases clínico-patológicas da medicina. vl. 1. Rio de Janeiro: Guanabara-Koogan; 2006. p.1224-91.
15. Jones K, Hughes J, Hong M, Jia Q, Orndorff S. Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. Pigment Cell Res. 2002;15:335-40.
16. Bolognia JL, Orlow SJ. Melanocyte biology. In: Bolognia JL, Jorizzo JL, Rapini RP. Dermatology. v. 1. New York: Mosby; 2003.
17. Rouzaud F, Kadekaro AL, Abdel-Malek ZA, Hearing VJ. MC1R and the response of melanocytes to ultraviolet radiation. Mutat Res. 2005;57:133-52.
18. Murisier F, Beermann F. Genetics of pigment cells: lessons from the tyrosinase gene family. Histol Histopathol. 2006;2:567-78.
19. Ito S. A chemist's view of melanogenesis. Pigment Cell Res. 2003;16:230-6.
20. Thody AJ, Graham A. Does alpha-MSH have a role in regulating skin pigmentation in humans? Pigment Cell Res. 1998;1:265-74.
21. Wagner JK, Parra EJ, LNorton H, Jovel C, Shriver MD. Skin responses to ultraviolet radiation: effects of constitutive pigmentation, sex, and ancestry. Pigment Cell Re. 2002;15:385-90.
22. Hearing VJ. Biogenesis of pigment granules: a sensitive way to regulate melanocyte function. J Dermatol Sci. 2005;37:3-14.
23. Boissy RE. Melanosome transfer to and translocation in the keratinocyte. Exp Dermato. 2003;12 Suppl 2:5-12.
24. Szabo G, Hirobe T, Flynn EA, Garcia RI. The biology of the melanocyte. Prog Clin Biol Res.1988;256:463-74.
25. Rouzaud F, Hearing VJ. Regulatory elements of the melanocortin 1 receptor. Peptides. 2005;26:1858-70.
26. Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 2004;84:1155-228.
27. Klaus SN, Snell RS. The response of mammalian epidermal melanocytes in culture to hormones. J Invest Dermatol. 1967;48:352-8.
28. Barsh G, Attardi LD. A healthy tan? N Engl J Med. 2007;356:2208-10.
29. Wickelgren I. Skin biology. A healthy tan? Science. 2007; 315:1214-6.
30. Bastiaens M, ter Huurne J, Gruis N, Bergman W, Westendorp R, Vermeer BJ, et al. The melanocortin-1-receptor gene is the major freckle gene. Hum Mol Genet. 2001;10:1701-8.
31. Prusis P, Schioth HB, Muceniece R, Herzyk P, Afshar M, Hubbard RE, et al. Modeling of the three-dimensional structure of the human melanocortin 1 receptor, using an automated method and docking of a rigid cyclic melanocyte-stimulating hormone core peptide. J Mol Graph Model.1997;15:307-17, 334.
32. Abdel-Malek Z, Scott MC, Suzuki I, Tada A, Im S, Lamoreux L, et al. The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation. Pigment Cell Res. 2000;13 Suppl 8:156-62.
33. Thody AJ. alpha-MSH and the regulation of melanocyte function. Ann N Y Acad Sci. 1999;885:217-29.
34. Voisey J, Carroll L, van Daal A. Melanocortins and their receptors and antagonists. Curr Drug Targets. 2003;4:586-97.
35. Prusis P, Frandberg PA, Muceniece R et al. A three dimensional model for the interaction of MSH with the melanocortin-1 receptor. Biochem Biophys Res Commun. 1995;210:205-10.
36. Mountjoy KG, Robbins LS, Mortrud MT, Kalvinsh I, Wikberg JE. The cloning of a family of genes that encode the melanocortin receptors. Science. 1992;257:1248-51.
37. Valverde P, Healy E, Jackson I, Rees JL, Thody AJ. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat Genet. 1995;11:328-30.
38. Rees JL. The melanocortin 1 receptor (MC1R): more than just red hair. Pigment Cell Res. 2000;13:135-40.
39. Tan CP, McKee KK, Weinberg DH, MacNeil T, Palyha OC, Feighner SD, et al. Molecular analysis of a new splice variant of the human melanocortin-1 receptor. FEBS Lett.1999;451:137-41.
40. Rouzaud F, Costin GE, Yamaguchi Y, Valencia JC, Berens WF, Chen KG, et al. Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms. Faseb J. 2006; 20:1927-9.
41. Schaffer JV, Bolognia JL. The melanocortin-1 receptor: red hair and beyond. Arch Dermatol. 2001;137:1477-85.
42. Loir B, Perez Sanchez C, Ghanem G, Lozano JA, García-Borrón JC, Jiménez-Cervantes C. Expression of the MC1 receptor gene in normal and malignant human melanocytes. A semiquantitative RT-PCR study. Cell Mol Biol (Noisy-le-grand).1999;45:083-92.
43. Leonard JH, Marks LH, Chen W, Cook AL, Boyle GM, Smit DJ, et al. Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: pigmentation marker, ultrastructural and UVsurvival studies. Pigment Cell Res. 2003;16:198-207.
44. Branicki W, Brudnik U, Kupiec T, Wolañska-Nowak P, Wojas-Pelc A. Determination of phenotype associated SNPs in the MC1R gene. J Forensic Sci. 2007;52:349-54.
45. Branicki W, Brudnik U, Kupiec T. J Invest Dermatol. 2004;123:414.
46. Motokawa T, Kato T, Hashimoto Y, Katagiri T. Effect of Val92Met and Arg163Gln variants of the MC1R gene on freckles and solar lentigines in Japanese. Pigment Cell Res. 2007;20:140-3.
47. Abdel-Malek Z, Suzuki I, Tada A, Im S, Akcali C. The melanocortin-1 receptor and human pigmentation. Ann N Y Acad Sci. 1999;885:117-33.
48. Ha T, Rees JL. Melanocortin 1 receptor: what's red got to do with it? J Am Acad Dermatol. 2001;45:961-4.
49. Ha T, Naysmith L, Waterston K, Oh C, Weller R, Rees JL. Defining the quantitative contribution of the melanocortin 1 receptor (MC1R) to variation in pigmentary phenotype. Ann N Y Acad Sci. 2003;994:339-47.
50. Scott MC, Wakamatsu K, Ito S, Kadekaro AL, Kobayashi N, Groden J, et al. Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation. J Cell Sci. 2002;115:2349-55.
51. Scott MC, Suzuki I, Abdel-Malek ZA. Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation. Pigment Cell Res. 2002;15:433-9.
52. Gantz I, Yamada T, Tashiro T, Konda Y, Shimoto Y, Miwa H, et al. Mapping of the gene encoding the melanocortin-1 (alpha-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24.3 by Fluorescence in situ hybridization. Genomics. 1994;19:394-5.
53. Hunt G, Thody AJ. Agouti protein can act independently of melanocyte-stimulating hormone to inhibit melano genesis. J Endocrinol. 1995;147:R1-4.
54. D'Orazio JA, Nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, et al. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature. 2006;443:340-4.
55. Sampaio SAP, Rivitti EA. Fotodermatoses. In: Sampaio SAP, Rivitti EA. Dermatologia. v. 1. São Paulo: Artes médicas; 1998. p. 629-42.
56. Funasaka Y, Chakraborty AK, Hayashi Y, Komoto M, Ohashi A, Nagahama M, et al. Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha. Br JDermatol. 1998;139:216-24.
57. Kang WH, Yoon KH, Lee ES, Kim J, Lee KB, Yim H, et al. Melasma: histopathological characteristics in 56 Korean patients. Br J Dermatol. 2002;146:228-37.
58. Bohm M, Metze D, Schulte U, Becher E, Luger TA, Brzoska T. Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ. Exp Dermatol. 1999;8:453-61.
59. Sanchez NP, Pathak MA, Sato S, Fitzpatrick TB, Sanchez JL, Mihm MC Jr. Melasma: a clinical, light microscopic, ultrastructural, and immunofluorescence study. J Am Acad Dermatol. 1981;4:698-710.
60. Johnston GA, Sviland L, McLelland J. Melasma of the arms associated with hormone replacement therapy. Br J Dermatol. 1998;139:932.
61. Piamphongsant T. Treatment of melasma: a review with personal experience. Int J Dermatol. 1998;3:897-903.
62. Grimes PE. Melasma. Etiologic and therapeutic considerations. Arch Dermatol. 1995;131:1453-7.
63. Ponzio HAS. Contribuição à classificação clínica e histopatológica dos melasmas [dissertação] . Porto Alegre: UFRGS; 1995. p. 157.
64. Guevara IL, Pandya AG. Melasma treated with hydroquinone, tretinoin, and a fluorinated steroid. Int J Dermatol. 2001;40:212-5.
65. Balkrishnan R, McMichael AJ, Camacho FT, Saltzberg F, Housman TS, Grummer S, et al. Development and validation of a health-related quality of life instrument for women with melasma. Br J Dermatol. 2003;149:572-7.
66. Cestari TF, Hexsel D, Viegas ML, Azulay L, Hassun K, Almeida AR, et al. Validation of a melasma quality of life questionnaire for Brazilian Portuguese language: the MelasQoL-BP study and improvement of QoL of melasma patients after triple combination therapy. Br J Dermatol. 2006;156 Suppl 1:13-20.
67. Dominguez AR, Balkrishnan R, Ellzey AR, Pandya AG. Melasma in Latina patients: cross-cultural adaptation and validation of a quality-of-life questionnaire in Spanish language. J Am Acad Dermatol. 2006;55:59-66.
68. Ponzio HAS, Cruz MF. Acurácia do exame sob a lâmpada de Wood na classificação dos cloasmas. An Bras Dermatol. 1993;68:325-8.
69. Wolf R, Wolf D, Tamir A, Politi Y. Melasma: a mask of stress. Br J Dermatol. 1991; 125: 192-3.
70. Robins AH. Melanosis after prolonged chlorpromazine therapy. S Afr Med J. 1975;49:1521-4.
71. Sacre RC, Fernandes NC, Vaisman M, Tendrich M. Melasma idiopático: avaliação das funções tireoidiana, prolactínica e gonadal feminina. An Bras Dermatol. 1996;71:195-8.
72. Scheinfeld NS. Melasma. Skinmed. 2007;6:35-7.
73. Rigopoulos D, Gregoriou S, Katsambas A. Hyperpigmentation and melasma. J Cosmet Dermatol. 2007;6:195-202.
74. Grimes P, Nordlund JJ, Pandya AG, Taylor S, Rendon M, Ortonne JP. Increasing our understanding of pigmentary disorders. J Am Acad Dermatol. 2006;54:S255-61.
75. Pandya A, Berneburg M, Ortonne JP, Picardo M. Guidelines for clinical trials in melasma. Pigmentation Disorders Academy. Br J Dermatol. 2006;156 Suppl 1: 21-8.
76. Hexsel D, Arellano I, Rendon M. Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation. Br J Dermatol. 2006; 156 Suppl:7-12.
77. Rendon M, Berneburg M, Arellano I, Picardo M. Treatment of melasma. J Am Acad Dermatol. 2006;54:S272-81.
78. Toyoda M, Morohashi M. Morphological alterations of epidermal melanocytes in photoageing: an ultrastructural and cytomorphometric study. Br J Dermatol. 1998;139:444-52.
79. Imokawa G. Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment Cell Res. 2004;17:96-110.
80. Kang HY, Hwang JS, Lee JY, Ahn JH, Kim JY, Lee ES, et al. The dermal stem cell factor and c-kit are overexpressed in melasma. Br J Dermatol. 2006;154:1094-9.
81. Im S, Kim J, On WY, Kang WH. Increased expression of alpha-melanocyte- stimulating hormone in the lesional skin of melasma. Br J Dermatol. 2002;146: 165-7.
82. Lieberman R, Moy L. Estrogen receptor expression in melasma: results from facial skin of affected patients. J Drugs Dermatol. 2008;7:463-5.
83. Grimes PE, Yamada N, Bhawan J. Light microscopic, immunohistochemical, and ultrastructural alterations in patients with melasma. Am J Dermatopathol. 2005;27:96-101.
84. Pache M, Glatz-Krieger K, Sauter G, Meyer P. Expression of sex hormone receptors and cell cycle proteins in melanocytic lesions of the ocular conjunctiva. Graefes Arch Clin Exp Ophthalmol. 2006;244:113-7.
85. Matsumura R, Takeuchi S, Takahashi S. Effect of estrogen on melanocortin-3 receptor mRNA expression in mouse pituitary glands in vivo and in vitro. Neuroendocrinology. 2004;80:143-51.
86. Chowers I, Livni N, Frucht-Pery J, Pe'er J. Immunostaining of the estrogen receptor in conjunctival primary acquired melanosis. Ophthalmic Res. 1999;31:210-2.
87. Jee SH, Lee SY, Chiu HC, Chang CC, Chen TJ. Effects of estrogen and estrogen receptor in normal human melanocytes. Biochem Biophys Res Commun. 1994;199:1407-12.
88. Sawaya ME, Garland LD, Rothe MJ, Honig LS, Hsia SL. Oestrogen and progesterone receptors in lentigo maligna. Br J Dermatol. 1988;118:69-71.
89. Naysmith L, Waterston K, Ha T, Flanagan N, Bisset Y, Ray A, et al. Quantitative measures of the effect of the melanocortin 1 receptor on human pigmentary status. J Invest Dermatol.2004;122:423-8.
90. Carroll L, Voisey J, van Daal A. Gene polymorphisms and their effects in the melanocortin system. Peptides. 2005;26:1871-85.
91. Rees JL. Genetics of hair and skin color. Annu Rev Genet. 2003;37:67-90.
92. Carlson JA, Linette GP, Aplin A, Ng B, Slominski A. Melanocyte receptors: clinical implications and therapeutic relevance. Dermatol Clin. 2007;25:541-57, viii-ix.
93. Sriwiriyanont P, Ohuchi A, Hachiya A, Visscher MO, Boissy RE. Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts. Lab Invest. 2006;86:1115-25.
94. Tada A, Suzuki I, Im S et al. Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation. Cell Growth Differ. 1998;9:575-84.