Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells

Allergology International

Volumn 59, Issue 1, 2010, Pages 67-73

  Iwamura, Chiaki ^a   Shinoda, Kenta ^a   Yoshimura, Mineka ^b   Watanabe, Yukiko ^a   Obata, Akio ^b   Nakayama, Toshinori ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KIKKOMAN CORPORATION   (Japan)

Author keywords

Airway hyperreactivity; Asthma; Prevention; Th2 cell; Tomato extract

Indexed keywords

CHALCONE DERIVATIVE; NARINGENIN CHALCONE; OVALBUMIN; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS HYPERREACTIVITY; BRONCHUS MUCUS; CD4+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; IN VIVO STUDY; LOEFFLER PNEUMONIA; LUNG LAVAGE; MOUSE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SENSITIZATION; TH2 CELL;

EID: 77949686197     PISSN: 13238930     EISSN: 14401592     Source Type: Journal    
DOI: 10.2332/allergolint.09-OA-0118     Document Type: Article

References (29)

1. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006;355:2226-35.
2. Umetsu DT, DeKruyff RH. The regulation of allergy and asthma. Immunol Rev 2006;212:238-55.
3. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001; 344:350-62.
4. Hamelmann E, Gelfand EW. IL-5-induced airway eosinophilia - the key to asthma? Immunol Rev 2001;179:182-91.
5. Wills-Karp M. Interleukin-13 in asthma pathogenesis. Immunol Rev 2004;202:175-90.
6. Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 2008;454:445-54.
7. Iwamura C, Nakayama T. Toll-like receptors in the respiratory system: their roles in inflammation. Curr Allergy Asthma Rep 2008;8:7-13.
8. Voynow JA, Gendler SJ, Rose MC. Regulation of mucin genes in chronic inflammatory airway diseases. Am J Respir Cell Mol Biol 2006;34:661-5.
9. Suzuki M, Yoshino K, Maeda-Yamamoto M, Miyase T, Sano M. Inhibitory effects of tea catechins and Omethylated derivatives of (-)-epigallocatechin-3- O-gallate on mouse type IV allergy. J Agric Food Chem 2000;48: 5649-53.
10. Yamamoto T, Yoshimura M, Yamaguchi F et al. Antiallergic activity of naringenin chalcone from a tomato skin extract. Biosci Biotechnol Biochem 2004;68:1706-11.
11. Akiyama H, Sato Y, Watanabe T et al. Dietary unripe apple polyphenol inhibits the development of food allergies in murine models. FEBS Lett 2005;579:4485-91.
12. Yoshimura M, Enomoto T, Dake Y et al. An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis. Allergol Int 2007;56:225-30.
13. Sur R, Nigam A, Grote D, Liebel F, Southall MD. Avenanthramides, polyphenols from oats, exhibit antiinflammatory and anti-itch activity. Arch Dermatol Res 2008;300:569-74.
14. Yoshimura M, Sano A, Kamei J, Obata A. Identification and quantification of metabolites of orally administered naringenin chalcone in rats. J Agric Food Chem 2009;57: 6432-7.
15. Iwamura C, Kimura MY, Shinoda K et al. Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness. Int Immunol 2007;19:755-62.
16. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999;103:175-83.
17. Kimura MY, Iwamura C, Suzuki A et al. Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. J Immunol 2007;178:4926-36.
18. Kimura M, Koseki Y, Yamashita M et al. Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity 2001;15:275-87.
19. Zhu J, Paul WE. CD4 T cells: fates, functions, and faults. Blood 2008;112:1557-69.
20. Lloyd CM, Gonzalo JA, Coyle AJ, Gutierrez-Ramos JC. Mouse models of allergic airway disease. Adv Immunol 2001;77:263-95.
21. Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999;17: 255-81.
22. Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunol 2006;24:147-74.
23. Denzler KL, Borchers MT, Crosby JR et al. Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation. J Immunol 2001;167:1672-82.
24. Denzler KL, Farmer SC, Crosby JR et al. Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma. J Immunol 2000;165:5509-17.
25. Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol 2008;8:205-17.
26. Aubry JP, Pochon S, Graber P, Jansen KU, Bonnefoy JY. CD21 is a ligand for CD23 and regulates IgE production. Nature 1992;358:505-7.
27. Rosenwasser LJ, Meng J. Anti-CD23. Clin Rev Allergy Immunol 2005;29:61-72.
28. Tan Y, Lim LH. trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation. Br J Pharmacol 2008;155:995-1004.
29. Yamakoshi J, Sato T, Matsumura T et al. Safety evaluation of flavonoids-containing tomato skin extract. Pharmacometrics 2004;67:313-21.