Salutary effects of estrogen receptor-β agonist on lung injury after trauma-hemorrhage

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 5, 2006, Pages

  Yu, Huang Ping ^a,b   Hsieh, Ya Ching ^a   Suzuki, Takao ^a   Shimizu, Tomoharu ^a   Choudhry, Mashkoor A ^a   Schwacha, Martin G ^a   Chaudry, Irshad H ^a,c  

^a Kentucky   (United States)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Diarylpropiolnitrile; Propyl pyrazole triol; Shock

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LACTATE DEHYDROGENASE; MESSENGER RNA; NITRATE; NITRITE; PROPIOLNITRILE; PROPYLPYRAZOLE TRIOL; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; LUNG EDEMA; LUNG HEMORRHAGE; LUNG INJURY; LUNG PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; ESTRADIOL; ESTROGEN RECEPTOR BETA; HEMORRHAGE; HUMANS; INTERLEUKIN-6; L-LACTATE DEHYDROGENASE; MALE; NITRATES; NITRILES; NITRITES; PROPIONATES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 33646538833     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00504.2005     Document Type: Article

References (38)

1. Ameredes BT, Zamora R, Gibson KF, Billiar TR, Dixon-McCarthy B, Watkins S, and Calhoun WJ. Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice. J Leukoc Biol 70: 730-736, 2001.
2. Ananthakrishnan P, Cohen DB, Xu DZ, Lu Q, Feketeova E, and Deitch EA. Sex hormones modulate distant organ injury in both a trauma/hemorrhagic shock model and a burn model. Surgery 137: 56-65, 2005.
3. Baker AE, Brautigam VM, and Watters JJ. Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor β. Endocrinology 145: 5021-5032, 2004.
4. Baue AE, Durham R, and Faist E. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock 10: 79-89, 1998.
5. Chaudry IH, Samy TSA, Schwacha MG, Wang P, Rue LW III, and Bland KI. Endocrine targets in experimental shock. J Trauma 54: S118-S125, 2003.
6. Cuzzocrea S, Mazzon E, Sautebin L, Serraino I, Dugo L, Calabro G, Caputi AP, and Maggi A. The protective role of endogenous estrogens in carrageenan-induced lung injury in the rat. Mol Med 7: 478-487, 2001.
7. Cuzzozrea S, Santagati S, Sautebin L, Mazzon E, Calabro G, Serraino I, Caputi AP, and Maggi A. 17β-Estradiol anti-inflammatory activity in carrageenan-induced pleurisy. Endocrinology 141: 1455-1463, 2000.
8. Deitch EA. Multiple organ failure: pathophysiology and potential future therapy. Ann Surg 216: 117-134, 1992.
9. Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, Billiar TR, and Tweardy DJ. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 187: 917-928, 1998.
10. Hierholzer C, Menezes JM, Ungeheuer A, Billiar TR, Tweardy DJ, and Harbrecht BG. A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock 17: 98-103, 2002.
11. Homo-Delarche F, Fitzpatrick F, Christeff N, Nunez EA, Bach JF, and Dardenne M. Sex steroids, glucocorticoids, stress and autoimmunity. J Steroid Biochem Mol Biol 40: 619-637, 1991.
12. Jarrar D, Kuebler JF, Rue LW III, Matalon S, Wang P, Bland KI, and Chaudry IH. Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-κB and MAPK/ERK mechanisms. Am J Physiol Lung Cell Mol Physiol 283: L799-L805, 2002.
13. Kiang JG, Lu X, Tabaku LS, Bentley TB, Atkins JL, and Tsokos GC. Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage. J Appl Physiol 98: 550-556, 2005.
14. Kimura Y, Hirooka Y, Sagara Y, Ito K, Kishi T, Shimokawa H, Takeshita A, and Sunagawa K. Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circ Res 96: 252-260, 2005.
15. Kuiper GGJM, Carlsson B, Grandien J, Enmark E, Haggblad J, Nilsson S, and Gustafsson JA. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptor α and β. Endocrinology 138: 863-870, 1997.
16. Kunz D, Mühl H, Walker G, and Pfeilschifter J. Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells. Proc Natl Acad Sci USA 91: 5387-5391, 1994.
17. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, and Evans RM. The nuclear receptor superfamily: the second decade. Cell 83: 835-839, 1995.
18. Meldrum DR, McIntyre RC, Sheridan BC, Cleveland JC Jr, Fullerton DA, and Harken AH. L-arginine decreases alveolar macrophage proinflammatory monokine production during acute lung injury by a nitric oxide synthase-dependent mechanism. J Trauma 43: 888-893, 1997.
19. Meyers MJ, Sun J, Carlson KE, Marriner GA, Katzenellenbogen BS, and Katzenellenbogen JA. Estrogen receptor-β potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem 44: 4230-4251, 2001.
20. Moore FA, Sauaia A, and Moore EE. Post injury multiple organ failure: a bimodal phenomenon. J Trauma 2: 501-513, 1996.
21. Noris M, Todeschini M, Zappella S, Bonazzola S, Zoja C, Corna D, Gaspari F, Marchetti G, Aiello S, and Remuzzi G. 17β-Estradiol corrects hemostasis in uremic rats by limiting vascular expression of nitric oxide synthases. Am J Physiol Renal Physiol 279: F626-F635, 2000.
22. Perrella MA, Yoshizumi M, Fen Z, Tsai JC, Hsieh CM, Kourembanas S, and Lee ME. Transforming growth factor-β1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1β in rat smooth muscle cells. J Biol Chem 269: 14595-14600, 1994.
23. Pittet JF, Lu LN, Geiser T, Lee H, Matthay MA, and Welch WJ. Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats. J Physiol 538: 583-597, 2001.
24. Remmer DE, Wang P, Cioffi WG, Bland KI, and Chaudry IH. Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males. Am J Physiol Heart Circ Physiol 273: H2919-H2925, 1997.
25. Samy TSA, Schwacha MG, Cioffi WG, Bland KI, and Chaudry IH. Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. Shock 14: 465-470, 2000.
26. Sir O, Fazal N, Choudhry MA, Goris RJ, Gamelli RL, and Sayeed MM. Role of neutrophils in burn-induced microvascular injury in the intestine. Shock 14: 113-117, 2000.
27. Skidgel RA, Gao XP, Brovkovych V, Rahman A, Jho D, Predescu S, Standiford TJ, and Malik AB. Nitric oxide stimulates macrophage inflammatory protein-2 expression in sepsis. J Immunol 169: 2093-2101, 2002.
28. Song Y, Ao L, Raebum CD, Calkins CM, Abraham E, Harken AH, and Meng X. A low level of TNF-α mediates hemorrhage-induced acute lung injury via p55 TNF receptor. Am J Physiol Lung Cell Mol Physiol 281: L677-L684, 2001.
29. Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, Sun J, Katzenellenbogen BS, and Katzenellenbogen JA. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-α selective agonists. J Med Chem 43: 4934-4947, 2000.
30. Szabo C and Billiar TR. Novel roles of nitric oxide in hemorrhagic shock. Shock 12: 1-9, 1999.
31. Tsai BM, Wang M, Clauss M, Sun P, and Meldrum DR. Endothelial monocyte-activating polypeptide II causes NOS-dependent pulmonary artery vasodilation: a novel effect for a proinflammatory cytokine. Am J Physiol Regul Integr Comp Physiol 287: R767-R771, 2004.
32. Wang P, Hauptman JG, and Chaudry IH. Hepatocellular dysfunction occurs early after hemorrhage and persists despite fluid resuscitation. J Surg Res 48: 464-470, 1990.
33. Wang W, Wang P, and Chaudry IH. Intestinal alkaline phosphatase: role in the depressed gut lipid transport after trauma-hemorrhagic shock. Shock 8: 40-44, 1997.
34. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, and Chaudry IH. Mechanism of immunosuppression in males following trauma-hemorrhage: critical role of testosterone. Arch Surg 131: 1186-1191, 1996.
35. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, and Chaudry IH. Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation. Cytokine 8: 853-863, 1996.
36. Wu LL, Tang C, and Liu MS. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Am J Physiol Regul Integr Comp Physiol 281: R408-R416, 2001.
37. Yu HP, Shimizu T, Choudhry MA, Hsieh YC, Suzuki T, Bland KI, and Chaudry IH. Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-β agonist: upregulation of cardiac heat shock factor-1 and heat shock proteins. J Mol Cell Cardiol 40: 185-194, 2006.
38. Yu HP, Yang S, Choudhry MA, Hsieh YC, Bland KI, and Chaudry IH. Mechanism responsible for the salutary effects of flutamide on cardiac performance following trauma-hemorrhagic shock: upregulation of cardiomyocyte estrogen receptors. Surgery 138: 85-92, 2005.