Stepwise synthesis of oligonucleotide-peptide conjugates containing guanidinium and lipophilic groups in their 3′-termini

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2144-2147

  Grijalvo, Santiago ^a   Terrazas, Montserrat ^a   Aviñó, Anna ^a   Eritja, Ramón ^a  

^a BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

Antisense oligonucleotide; Dickerson Drew dodecamer; Luciferase; ODN peptide conjugates; Phosphorothioates; Postsynthetic guanidinylation reaction; Ureas

Indexed keywords

AMINE; ANTISENSE OLIGODEOXYNUCLEOTIDE; CARBONYL DERIVATIVE; FLUORENYLMETHYLOXYCARBONYL CHLORIDE; GUANIDINE; LYSINE; OLIGONUCLEOTIDE; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; UNCLASSIFIED DRUG; UREA;

3' UNTRANSLATED REGION; ARTICLE; CHEMICAL REACTION; CONJUGATION; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG SYNTHESIS; GUANIDINYLATION; HUMAN; HUMAN CELL; LIPOPHILICITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE SYNTHESIS;

ANIMALS; BASE SEQUENCE; CELL LINE; GENE SILENCING; GUANIDINE; LUCIFERASES; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDES; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RENILLA;

EID: 77949657147     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.049     Document Type: Article

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