GITR expression on T-cell receptor-stimulated human CD8+ T cell in a JNK-dependent pathway

Indian Journal of Human Genetics

Volumn 15, Issue 3, 2009, Pages 121-124

  Chattopadhyay, Subhasis ^a,b   Chakraborty, Nitya G ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b NATIONAL INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

Author keywords

GITR; Human CD8+ T cell; JNK; T cell receptor

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CD3 ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; T LYMPHOCYTE RECEPTOR;

ARTICLE; CD8+ T LYMPHOCYTE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; PHOSPHORYLATION; PROTEIN EXPRESSION;

EID: 77949640918     PISSN: 09716866     EISSN: 1998362X     Source Type: Journal    
DOI: 10.4103/0971-6866.60188     Document Type: Article

References (16)

1. Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 1997;94:6216-6221
2. Nocentini G, Bartoli A, Ronchetti S, Giunchi L, Cupelli A, Delfino D, et al. Gene structure and chromosomal assignment of mouse GITR: A member of the tumor necrosis factor/nerve growth factor receptor family. DNA Cell Biol 2002;19:207-219
3. Nocentini G, Riccardi C. GITR: A multifaceted regulator of immunity belonging to thetumor necrosis factor receptor superfamily. Eur J Immunol 2005;35:1016-1022
4. McHugh R, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, et al. CD41 CD251 immunoregulatory T cells: Gene expression analysis reveals afunctional role for the glucocorticoid-induced TNF receptor. Immunity 2002;16:311-323
5. Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S, Stimulation ofCD251 CD41 regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002;3:135-142
6. Ronchetti S, Zollo O, Bruscoli S, Agostini M, Bianchini R, Nocentini G, et al. GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur J Immunol 2004;34:613-622
7. Mehrotra S, Chhabra A, Chattopadhyay S, Dorsky DI, Chakraborty NG, Mukherji B. Rescuing melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death, by SP600125, an inhibitor of JNK: Implications in cancer immunotherapy. J Immunol 2004;173:6017-6024
8. Chattopadhyay S, Chakraborty NG. Continuous presence of Th1 conditions is necessary for longer lasting tumor-specific CTL activity in stimulation cultures with PBL. Hum Immunol 2005;66:884-891
9. Chattopadhyay S, Chakraborty NG, Mukherji B. Regulatory T cells and tumor immunity. Cancer Immunol Immunother 2005;54:1153-1161
10. Chattopadhyay S, Mehrotra S, Chhabra A, Hegde U, Mukherji B, Chakraborty NG. Effect of CD41 CD251 and CD41 CD252 T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro. J Immunol 2006;176:984-990
11. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, et al. SP600125: An anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001;98:13681-13686
12. + T cell activation. J Exp Med 2002;195:811-823
13. + T cells. Immunol Rev 2003;192:131-142
14. + T lymphocytes in control of Mycobacterium tuberculosis infection. Microbes Infect 2005;7:776-788
15. Snyder JT, Alexander-Miller MA, Berzofskyl JA, Belyakov IM. Molecular mechanisms and biological significance of CTL avidity. Curr HIV Res 2003;1:287-294
16. + T cells in autoimmunity. Curr Opin Immunol 2005;17:624-631