Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma

Cancer Science

Volumn 101, Issue 3, 2010, Pages 624-630

  Ling, Zhi Qiang ^a,c   Mukaisho, Ken Ichi ^a   Yamamoto, Hiroto ^b   Chen, Kuan Hao ^a   Asano, Shinji ^b   Araki, Yoshio ^a   Sugihara, Hiroyuki ^a   Mao, Wei Min ^c   Hattori, Takanori ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b RITSUMEIKAN UNIVERSITY   (Japan)

^c ZHEJIANG CANCER HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EZRIN; MOESIN; RADIXIN;

AMPLICON; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; CELL LINE; CHROMOSOMAL INSTABILITY; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CYTOSKELETON; DNA EXTRACTION; DOWN REGULATION; DUODENOGASTRIC REFLUX; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOSS; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC GAIN; GENOMIC INSTABILITY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; WESTERN BLOTTING;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; CYTOSKELETAL PROTEINS; DUODENOGASTRIC REFLUX; ESOPHAGEAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY;

EID: 77949608574     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01470.x     Document Type: Article

References (47)

1. Parkin DM, Bray F, Ferlay J. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001, 94:153-6.
2. Nozoe T, Korenaga D, Kabashima A. Smoking-related increase of O(6)-methylguanine-DNA methyltransferase expression in squamous cell carcinoma of the esophagus. Cancer Lett 2002, 8:49-55.
3. Devesa S, Blot WJ, Fraumeni JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998, 83:2049-53.
4. Yokoyama A, Ohmori T, Muramatsu T. Cancer screening of upper aerodigestive tract in Japanese alcoholics with reference to drinking and smoking habits and aldehyde dehydrogenase-2 genotype. Int J Cancer 1996, 68:313-6.
5. Lagergren J, Bergstrom R, Lindgren A. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999, 340:825-31.
6. Kumagai H, Mukaisho K, Sugihara H. Cell kinetic study on histogenesis of Barrett's esophagus using rat reflux model. Scand J Gastroenterol 2003, 38:687-92.
7. Kumagai H, Mukaisho K, Sugihara H. Thioproline inhibits development of esophageal adenocarcinoma induced by gastroduodenal reflux in rats. Carcinogenesis 2004, 25:723-7.
8. Chen KH, Mukaisho K, Sugihara H. High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model. Cancer Sci 2007, 98:1683-8.
9. Chen KH, Mukaisho K, Ling ZQ. Association between duodenal contents reflux and squamous cell carcinoma - establishment of an esophageal cancer cell line derived from the metastatic tumor in a rat reflux model. Anticancer Res 2007, 27:175-81.
10. Xie JJ, Xu LY, Xie YM. Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cells. Int J Cancer 2009, 124:2549-58.
11. Zeng H, Xu L, Xiao D. Altered expression of ezrin in esophageal squamous cell carcinoma. J Histochem Cytochem 2006, 54:889-96.
12. Vaheri A, Carpén O, Heiska L. The ezrin protein family: membrane-cytoskeleton interactions and disease associations. Curr Opin Cell Biol 1997, 9:659-66.
13. Berryman M, Franck Z, Bretscher A. Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells. J Cell Sci 1993, 105:1025-43.
14. Bretscher A, Chambers D, Nguyen R. ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Annu Rev Cell Dev Biol 2000, 16:113-43.
15. Tsukita S, Oishi K, Sato N. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol 1994, 126:391-401.
16. Reczek D, Berryman M, Bretscher A. Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J Cell Biol 1997, 139:169-79.
17. Serrador JM, Nieto M, Sanchez-Madrid F. Cytoskeletal rearrangement during migration and activation of T lymphocytes. Trends Cell Biol 1999, 9:228-33.
18. Ng T, Parsons M, Hughes WE. Ezrin is a downstream effector of trafficking PKCintegrin complexes involved in the control of cell motility. EMBO J 2001, 20:2723-41.
19. Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 2002, 3:586-99.
20. Wu KL, Khan S, Lakhe-Reddy S. The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. J Biol Chem 2004, 279:26280-6.
21. Ramesh V. Merlin and the ERM proteins in Schwann cells, neurons and growth cones. Nat Rev Neurosci 2004, 5:462-70.
22. Gary R, Bretscher A. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. Mol Biol Cell 1995, 6:1061-75.
23. Hirao M, Sato N, Kondo T. Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol 1996, 135:37-51.
24. Fievet BT, Gautreau A, Roy C. Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol 2004, 164:653-9.
25. Matsui T, Maeda M, Doi Y. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol 1998, 140:647-57.
26. Tsukita S, Yonemura S. Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. J Biol Chem 1999, 274:34507-10.
27. Ohtani K, Sakamoto H, Rutherford T. Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion of endometrial cancer cells. Cancer Lett 1999, 147:31-8.
28. Khanna C, Wan X, Bose S. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 2004, 10:182-6.
29. Yu Y, Khan J, Khanna C. Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Nat Med 2004, 10:175-81.
30. Elliott BE, Meens JA, SenGupta SK. The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res 2005, 7:R365-73.
31. Ilmonen S, Vaheri A, Asko-Seljavaara S. Ezrin in primary cutaneous melanoma. Mod Pathol 2005, 18:503-10.
32. Weng WH, Ahlen J, Astrom K. Prognostic impact of immuno-histochemical expression of ezrin in highly malignant soft tissue sarcomas. Clin Cancer Res 2005, 11:6198-204.
33. Kobel M, Gradhand E, Zeng K. Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma. Int J Gynecol Pathol 2006, 25:121-30.
34. Bruce B, Khanna G, Ren L. Expression of the cytoskeleton linker protein ezrin in human cancers. Clin Exp Metastasis 2007, 24:69-78.
35. Asano S, Tega Y, Konishi K. Functional expression of gastric H+, K(+) - ATPase and site-directed mutagenesis of the putative cation binding site and catalytic center. J Biol Chem 1996, 271:2740-5.
36. Dennish GW, Castell DO. Inhibitory effect of smoking on the lower esophageal sphincter. N Engl J Med 1971, 284:1136-7.
37. Smit CF, Copper MP, van Leeuwen JA. Effect of cigarette smoking on gastropharyngeal and gastroesophageal reflux. Ann Otol Rhinol Laryngol 2001, 110:190-3.
38. Kadakia SC, Kikendall JW, Maydonovitch C. Effect of cigarette smoking on gastroesophageal reflux measured by 24-h ambulatory esophageal pH monitoring. Am J Gastroenterol 1995, 90:1785-90.
39. Kaufman SE, Kaye MD. Induction of gastro-oesophageal reflux by alcohol. Gut 1978, 19:336-8.
40. Vitale GC, Cheadle WG, Patel B. The effect of alcohol on nocturnal gastroesophageal reflux. JAMA 1987, 258:2077-9.
41. Miwa K, Hattori T, Miyazaki I. Duodenogastric reflux and foregut carcinogenesis. Cancer 1995, 75:1426-32.
42. Suo M, Mukaisho K, Shimomura A. Thioproline prevents carcinogenesis in the remnant stomach induced by duodenal reflux. Cancer Lett 2006, 237:256-62.
43. Terasaki M, Totsuka Y, Nishimura K. Detection of endogenous DNA adducts, O-carboxymethyl-2′-deoxyguanosine and 3-ethanesulfonic acid-2′-deoxycytidine, in the rat stomach after duodenal reflux. Cancer Sci 2008, 99:1741-6.
44. Shen ZY, Xu LY, Li EM. Ezrin, actin and cytoskeleton in apoptosis of esophageal epithelial cells induced by arsenic trioxide. Int J Mol Med 2003, 12:341-7.
45. Federici C, Brambilla D, Lozupone F. Pleiotropic function of ezrin in human metastatic melanomas. Int J Cancer 2009, 124:2804-12.
46. Louvet-Vallée S. ERM proteins: from cellular architecture to cell signaling. Biol Cell 2000, 92:305-16.
47. Ren L, Hong SH, Cassavaugh J. The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene 2009, 28:792-802.