Insoluble carob fiber rich in polyphenols lowers total and ldl cholesterol in hypercholesterolemic sujects

Plant Foods for Human Nutrition

Volumn 65, Issue 1, 2010, Pages 50-56

  Ruiz Roso, Baltasar ^a   Quintela, José C ^b   de la Fuente, Ester ^b   Haya, Javier ^c   Pérez Olleros, Lourdes ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b Puleva Biotech SA   (Spain)

^c HOSPITAL UNIVERSITARIO SANTA CRISTINA   (Spain)

Author keywords

Dietary fiber; Exxenterol; HDL cholesterol; Hyperlipemia; Insoluble polyphenols; LDL cholesterol; Total cholesterol

Indexed keywords

ALGAROBA; CHOLESTEROL; FLAVONOID; GALACTAN; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MANNAN; PHENOL DERIVATIVE; PLANT GUM; PLANT MEDICINAL PRODUCT; POLYPHENOLS; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DIETARY FIBER; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; LEGUME; MALE; MIDDLE AGED; PHYTOTHERAPY; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL, LDL; DIETARY FIBER; DOUBLE-BLIND METHOD; FABACEAE; FEMALE; FLAVONOIDS; GALACTANS; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MANNANS; MIDDLE AGED; PHENOLS; PHYTOTHERAPY; PLANT GUMS; PLANT PREPARATIONS; TRIGLYCERIDES;

ANIMALIA; CERATONIA SILIQUA;

EID: 77949541094     PISSN: 09219668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11130-009-0153-9     Document Type: Article

References (33)

1. Kannel WB (1996) Preventive efficacy of nutritional counseling. Arch Intern Med 156: 1138-1139.
2. Caggiula AW, Watson JE, Kuller LH, Olson MB, Milas NC, Berry M, Germanowski J (1996) Cholesterol-lowering intervention program. Effect of the step I diet in community office practices. Arch Intern Med 156: 1205-1213.
3. Ripsin C, Keenan J, Jacobs D (1992) Oat products and lipid lowering. JAMA 267: 3317-3325.
4. Glore SR, van Treeck D, Knehans AW, Guild M (1994) Soluble fiber and serum lipids: a literature review. J Am Diet Assoc 94: 425-436.
5. Brown L, Rosner B, Willet W, Sacks F (1999) Colesterol lowering effects of dietary fiber: a metanalysis. Am J Clin Nutr 69: 30-42.
6. Marakis S (1996) Carob bean in food and feed: current status and future potentials-a critical appraisal. J Food Sci Technol 33: 365-383.
7. Wursch P (1979) Influence of tanninrich carob pod fiber on the cholesterol metabolism in the rat. J Nutr 109: 685-692.
8. Pérez-Olleros L, Garcia-Cuevas M, Ruiz-Roso B, Requejo A (1999) Comparative study of natural carob fibre and psyllium husk in rats. Influence on some aspects of nutritional utilisation and lipidaemia. J Sci Food Agric 79: 173-178.
9. Pérez-Olleros L, Garcia-Cuevas M, Ruiz-Roso B (1999) Influence of pulp and natural carob fiber on some aspects of nutritional utilisation and lipidaemia. Food Sci Tech Int 5: 425-430.
10. Ruiz-Roso B, Pérez-Olleros L, Requejo A (2003) El Exxenterol, un extracto de fibra vegetal con un potente efecto reductor del colesterol. Schironia 2: 5-9.
11. Zunft HJ, Lueder W, Harde A, Haber B, Graubaum HJ, Gruenwald J (2001) Carob pulp preparation for treatment of hypercholesterolemia. Adv Ther 18: 230-236.
12. Zunft HJ, Lueder W, Harde A, Haber B, Graubaum HJ, Koebnick C, Gruenwald J (2003) Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients. Eur J Nutr 42: 235-242.
13. Ruiz-Roso B, Requejo A, Haya J, Pérez-Olleros L (2008) Efecto hipolipémico del exxenterol. Schironia 7: 21-25.
14. Ruiz-Roso B, Requejo A, Pérez-Olleros L, Holguín JA (2008) A product of vegetal origin comprising proanthocyanidines and its preparation process. European Patent No. EP1768682 B1.
15. AOAC (1997) Official methods of analyses, 16th edn. Association of Official Analytical Chemist, Washington.
16. Prosky L, Asp NG, Schweizer TF, De Vries JW, Furda L (1988) Determination of insoluble, soluble and total dietary fibre in foods and food products: collaboration study. JAOAC 71: 1017-1023.
17. Singleton VL, Orthofer R, Lamuela-Raventos RM (1999) Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299: 152-178.
18. Reed J, McDowell RE, van Soest PJ, Hovarth PJ (1982) Condensed tannins a factor limiting the use of cassava forage. J Sci Food Agric 33: 213-220.
19. Moher D, Schulz KF, Altman DG (2001) The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 357: 1191-1194.
20. LaRosa JC (2007) Low-density lipoprotein cholesterol reduction: the end is more important than the means. Am J Cardiol 100(2): 240-242.
21. Lewis SJ (2009) Prevention and treatment of atherosclerosis: a practitioner's guide for 2008. Am J Med 122(1 Suppl): S38-S50.
22. Shimizu C, Kihara M, Aoe S, Araki S, Ito K, Hayashi K, Watari J, Sakata Y, Ikegami S (2008) Effect of high beta-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men-a randomized, double-blinded, placebo-controlled trial. Plant Foods Hum Nutr 63(1): 21-25.
23. Theuwissen E, Mensink RP (2008) Water-soluble dietary fibers and cardiovascular disease. Physiol Behav 94(2): 285-292.
24. Anderson JW, Baird P, Davis RH Jr, Ferreri S, Knudtson M, Koraym A, Waters V, Williams CL (2009) Health benefits of dietary fiber. Nutr Rev 67(4): 188-205.
25. Slavin JL, Savarino V, Paredes-Diaz A, Fotopoulos G (2009) A review of the role of soluble fiber in health with specific reference to wheat dextrin. J Int Med Res 37(1): 1-17.
26. Jenkins AL, Vuksan V, Jenkins DJA (2001) Fiber in the treatment of hyperlipidemia. In: Spiller GA (ed) Handbook of dietary fiber in human nutrition. CRC Press LLC, Boca Raton, pp 401-421.
27. van Bennekum AM, Nguyen DV, Schulthess G, Hauser H, Phillips MC (2005) Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: relationships with intestinal and hepatic cholesterol parameters. Br J Nutr 94(3): 331-337.
28. John S, Sorokin AV, Thompson PD (2007) Phytosterols and vascular disease. Curr Opin Lipidol 18(1): 35-40.
29. Osada K, Suzuki T, Kawakami Y, Senda M, Kasai A, Sami M, Ohta Y, Kanda T, Ikeda M (2006) Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol. Lipids 41(2): 133-139.
30. Guo H, Ling W, Wang Q, Liu C, Hu Y, Xia M, Feng X, Xia X (2007) Effect of anthocyanin-rich extract from black rice (Oriza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats. Plant Foods Hum Nutr 62(1): 1-6.
31. Azadbakht L, Atabak S, Esmaillzadeh A (2008) Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial. Diabetes Care 31(4): 648-654.
32. Gelissen JC, Brodie B, Eastwood MA (1994) Effect of Plantago ovata (psyllium) husks and seeds on sterol metabolism: studies in normal and ileostomy subjects. Am J Clin Nutr 59: 395-400.
33. Fukushima M, Nakano M, Morii Y, Ohashi T, Fujiwara Y, Sonoyama K (2000) Hepatic LDL receptor mRNA in rats is increased by dietary mushroom (Agaricus bisporus) fiber and sugar beet fiber. J Nutr 130: 2151-2156.