The cationic cluster of group IVA phospholipase A 2 (Lys 488 /Lys 541 /Lys 543 /Lys 544) is involved in translocation of the enzyme to phagosomes in human macrophages

Journal of Lipid Research

Volumn 51, Issue 2, 2010, Pages 388-399

  Casas, Javier ^a   Valdearcos, Martín ^a,b   Pindado, José ^a   Balsinde, Jesús ^a,b   Balboa, María A ^a,b  

^a University of Valladolid   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Infl ammation; Lipid mediators; Monocytes macrophages; Phagocytosis; Phospholipase A 2

Indexed keywords

ANION; CATION; LYSINE DERIVATIVE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 GROUP IV; PHOSPHOLIPASE A2 GROUP IVA; PHOSPHOLIPASE C GAMMA1; UNCLASSIFIED DRUG; ZYMOSAN; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; LYSINE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MACROPHAGE; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TRANSPORT; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVE SITE; GENETICS; METABOLISM; MUTATION;

CATALYTIC DOMAIN; ENZYME ACTIVATION; GREEN FLUORESCENT PROTEINS; GROUP IV PHOSPHOLIPASES A2; HUMANS; LYSINE; MACROPHAGES; MUTATION; PHAGOCYTOSIS; PHAGOSOMES; PROTEIN TRANSPORT; ZYMOSAN;

EID: 77949533550     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M001461     Document Type: Article

References (48)

1. 2 superfamily and its group numbering system. Biochim. Biophys. Acta. 1761: 1246-1259.
2. 2. Annu. Rev. Pharmacol. Toxicol. 39: 175-189.
3. 2 regulation of arachidonic acid mobilization. FEBS Lett. 531: 2-6.
4. 2 in activated cells. Cell. Signal. 17: 1052-1062.
5. Balboa, M. A., and J. Balsinde. 2006. Oxidative stress and arachi-donic acid mobilization. Biochim. Biophys. Acta. 1761: 385-391.
6. Funk, C. D. 2001. Prostaglandins and leukotrienes: advances in ei-cosanoid biology. Science. 294: 1871-1875.
7. Serhan, C. N., N. Chiang, and T. E. Van Dyke. 2008. Resolving in-fl ammation: dual anti-infl ammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8: 349-361.
8. Bailie, M. B., T. J. Standiford, L. L. Laichalk, M. J. Coffery, R. Strieter, and M. Peters-Golden. 1996. Leukotriene-defi cient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J. Immunol. 157: 5221-5224.
9. 2 family. Prog. Lipid Res. 45: 487-510.
10. 2. Nature. 390: 622-625.
11. 2 in allergic response and parturition. Nature. 390: 618-622.
12. 2
13. 2. J. Biol. Chem. 277: 23838-23846.
14. 2 binds with high affi nity and specifi city to phosphatidylinositol 4,5-bisphosphate resulting in dramatic increases in activity. J. Biol. Chem. 273: 2184-2191.
15. 2 C2 domain for interfacial activity. J. Biol. Chem. 278: 23842-23850.
16. 2 via distinct and separate mechanisms. J. Lipid Res. 48: 2701-2708.
17. 2 to perinuclear membranes and decreases its calcium requirement for translocation in live cells. Mol. Biol. Cell. 17: 155-162.
18. 2a in regulating interfacial kinetics and binding and cellular function. J. Biol. Chem. 284: 9596-9611.
19. Stuart, L. M., and A. B. Ezekowitz. 2005. Phagocytosis: elegant com-plexity. Immunity. 22: 539-550.
20. 2 translocates to forming phagosomes during phagocytosis of zymosan in macrophages. J. Biol. Chem. 279: 19113-19121.
21. 2-dependent mechanisms in the ATP-mediated potentiation of antimycobacterial host resistance. J. Immunol. 175: 6741-6749.
22. 2 x does not regulate neutrophil NADPH oxidase activity., J. Biol. Chem., 280, 7519-7529.
23. 2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. J. Biol. Chem. 281: 6691-6698.
24. 2 concentration monitored in living cells. Curr. Biol. 8: 343-346.
25. 2 s in P388D 1 macrophages using GFP/RFP constructs. Biochim. Biophys. Acta. 1735: 119-129.
26. 2 protects cells from calcium-dependent death. J. Biol. Chem. 281: 6106-6116.
27. Larsen, E. C, J. A. DiGennaro, N. Saito, S. Mehta, D. J. Loegering, J. E. Mazurkiewicz, and M. R. Lennartz. 2000. Differential requirement for classic and novel PKC isoforms in respiratory burst and phagocytosis in RAW 264.7 cells. J. Immunol. 165: 2809-2817.
28. Marshall, J. G., J. W. Booth, V. Stambolic, T. Mak, T. Balla, A. D. Schreiber, T. Meyer, and S. Grinstein. 2001. Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis. J. Cell Biol. 153: 1369-1380.
29. 2 x, pyrrophenone. Biochem. J. 363: 727-735.
30. 2 s using fl uorogenic phospholipids. Methods Enzymol. 434: 15-27.
31. Botelho, R. J., M. Teruel, R. Dierckman, R. Anderson, A. Wells, J. D. York, Y. Meyer, and S. Grinstein. 2000. Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J. Cell Biol. 151: 1353-1367.
32. 2 in caveolin-enriched granules in activated P388D 1 macrophage-like cells. J. Biol. Chem. 278: 48059-48065.
33. 2 localizes in and protects mitochondria during apoptotic induction by staurosporine. J. Biol. Chem. 281: 22275-22288.
34. Fitzpatrick, F. A., and R. Soberman. 2001. Regulated formation of eicosanoids. J. Clin. Invest. 107: 1347-1351.
35. 2 to plasma membranes mediated by the NADPH oxidase in phagocytes. J. Cell Biol. 162: 683-692.
36. Wooten, R. E., M. C. Willingham, L. W. Daniel, C. C. Leslie, L. C. Rogers, S. Sergeant, and J. T. O'Flaherty. 2008. Novel translocation responses of cytosolic phospholipase A2alpha fl uorescent proteins. Biochim. Biophys. Acta. 1783: 1544-1550.
37. Balsinde, J., B. Fernandez, and E. Diez. 1990. Regulation of arachi-donic acid release in mouse peritoneal macrophages. The role of extracellular calcium and protein kinase C. J. Immunol. 144: 4298-4304.
38. Balsinde, J., B. Fernández, J. A. Solís-Herruzo, and E. Diez. 1992. Pathways for arachidonic acid mobilization in zymosan-stimulated mouse peritoneal macrophages. Biochim. Biophys. Acta. 1136: 75-82.
39. 2 activation by phosphorylation in mouse peritoneal macrophages. J. Biol. Chem. 268: 24506-24513.
40. 1 macrophages. Biochem. J. 321: 805-809.
41. 2-mediated oleic acid mobilization in lipopolysaccha-ride-stimulated P388D1 macrophages. J. Biol. Chem. 275: 4783-4786.
42. 2 regulation. J. Biol. Chem. 275: 20146-20156.
43. 1 macrophage-like cells. J. Biol. Chem. 275: 22544-22549.
44. 2 activation and cyclooxy-genase 2 expression in macrophages by the beta-glucan receptor. J. Biol. Chem. 281: 5506-5514.
45. 2 in providing lysophospholipid acceptors for fatty acid phospholipid incorporation and remodelling. Biochem. J. 364: 695-702.
46. 2 is required for lysozyme secretion in U937 promonocytes. J. Immunol. 170: 5276-5280.
47. 2 in hydrogen peroxide-induced accumulation of free fatty acids in human U937 cells. J. Biol. Chem. 277: 40384-40389.
48. 2 in arachidonic acid release, phospholipid fatty acid incorporation, and apoptosis in U937 cells responding to hydrogen peroxide. J. Biol. Chem. 279: 40385-40391.