Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2α in regulating interfacial kinetics and binding and cellular function

Journal of Biological Chemistry

Volumn 284, Issue 14, 2009, Pages 9596-9611

  Tucker, Dawn E ^a   Ghosh, Moumita ^a   Ghomashchi, Farideh ^b   Loper, Robyn ^a   Suram, Saritha ^a   St John, Bonnie ^a   Girotti, Milena ^c   Bollinger, James G ^b   Gelb, Michael H ^b   Leslie, Christina C ^a,d  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACIDS; BISPHOSPHATE; CALCIUM MOBILIZATION; CALCIUM OSCILLATION; CALCIUM TRANSIENTS; CATALYTIC DOMAINS; CELLULAR FUNCTION; CONCENTRATION OF; CYTOSOLIC PHOSPHOLIPASE; EXTRACELLULAR; HYDROLYTIC ACTIVITIES; IN-VITRO; INTERFACIAL BINDING; INTERFACIAL KINETIC; LOW-AMPLITUDE; MOUSE LUNG; PHORBOL 12 MYRISTATE 13 ACETATES; PHOSPHATIDYLINOSITOL; PHOSPHORYLATION SITES; WILD TYPES;

BINDING ENERGY; CALCIUM; CALCIUM ALLOYS; CELL CULTURE; CELL MEMBRANES; PHOSPHOLIPIDS; PHOSPHORYLATION; PLANTS (BOTANY);

BINDING SITES;

ARACHIDONIC ACID; CALCIUM; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE A2; PHOSPHOLIPID; DRUG DERIVATIVE; PHORBOLOL MYRISTATE ACETATE; PHOSPHOLIPASE A2 GROUP IV;

ANIMAL CELL; ARTICLE; BINDING KINETICS; BINDING SITE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL FUNCTION; CELL IMMORTALIZATION; CELL KINETICS; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EXTRACELLULAR CALCIUM; GENE MUTATION; GOLGI COMPLEX; IN VITRO STUDY; LIPID HYDROLYSIS; LUNG FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WILD TYPE; ANIMAL; CELL CULTURE; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KINETICS; METABOLISM; MOUSE MUTANT; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT;

ANIMALS; CALCIUM; CATALYTIC DOMAIN; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GROUP IV PHOSPHOLIPASES A2; HUMANS; KINETICS; MICE; MICE, KNOCKOUT; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT; TETRADECANOYLPHORBOL ACETATE;

EID: 66149150981     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807299200     Document Type: Article

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