Fold-Unfold transitions in the selectivity and mechanism of action of the N-Terminal fragment of the bactericidal/permeability-increasing protein (rBPI21)

Biophysical Journal

Volumn 96, Issue 3, 2009, Pages 987-996

  Domingues, Marco M ^a   Lopes, Sílvia C D N ^b   Santos, Nuno C ^a   Quintas, Alexandre ^c   Castanho, Miguel A R B ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^c INSTITUTO SUPERIOR DE CIÊNCIAS DA SAÚDE EGAS MONIZ   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; BACTERICIDAL PERMEABILITY INCREASING PROTEIN 21; LIPOSOME; PHOSPHOLIPID; RECOMBINANT PROTEIN; STEARIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; DISULFIDE; LIPOPOLYSACCHARIDE; PEPTIDE FRAGMENT; PLASMA PROTEIN; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL MEMBRANE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DISULFIDE BOND; DRUG MECHANISM; DRUG SELECTIVITY; MEMBRANE BINDING; MEMBRANE MODEL; MENINGOCOCCOSIS; NONHUMAN; PARTITION COEFFICIENT; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SEPSIS; SEPTIC SHOCK; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; LIGHT; LIPID BILAYER; METABOLISM; PROTEIN DENATURATION; RADIATION SCATTERING; SPECTROFLUOROMETRY; TEMPERATURE;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA;

ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD PROTEINS; CELL MEMBRANE; CIRCULAR DICHROISM; DISULFIDES; LIGHT; LIPID BILAYERS; LIPOPOLYSACCHARIDES; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PHOSPHOLIPIDS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; RECOMBINANT PROTEINS; SCATTERING, RADIATION; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TEMPERATURE; WATER;

EID: 61549096250     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2008.10.044     Document Type: Article

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