Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1746-1752

  Guan, Li Ping ^a,b   Sui, Xin ^b   Deng, Xian Qing ^b   Quan, Ying Chun ^b   Quan, Zhe Shan ^b  

^a ZHEJIANG OCEAN UNIVERSITY   (China)

^b YANBIAN UNIVERSITY   (China)

Author keywords

1,2,4 Triazolo 4,3 b pyridazine; Anticonvulsant activity; Chemical induced models; Maximal electroshock test; Neurotoxicity

Indexed keywords

6 (2,4 DICHLOROPHENOXY)[1,2,4]TRIAZOLO[4,3 B]PYRIDAZINE; 6 ALKOXY[1,2,4]TRIAZOLO[4,3 B]PYRIDAZINE; CARBAMAZEPINE; PHENOBARBITAL; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTICONVULSANT ACTIVITY; ARTICLE; CHEMICALLY INDUCED DISORDER; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; MOUSE; NEUROTOXICITY; NONHUMAN; QUANTITATIVE ANALYSIS; SEIZURE;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PYRIDAZINES; ROTAROD PERFORMANCE TEST; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 77949487749     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.077     Document Type: Article

References (30)

1. Jones O.T. Eur. J. Pharmacol 447 (2002) 211-225
2. Rang H.P., Dale J.M., and Rilter J.M. Pharmacology. fourth ed. (1999) Edinburgh, London, New York, Philadelphia, Sydney, Torontopp. 566
3. World Health Organization Fact Sheet no. 165. Epilepsy: epidemiology, actiology and prognosis (2001). http://www.who.int/mediacentre/fact sheets/fs 165/en/Accessed 22 March 2006
4. Schmidt D., and Löscher W. Epilepsia 46 (2005) 858-877
5. Al-Sound Y.A., Al-Masoudi N.A., and Ferwanah A.-R. Bioorg. Med. Chem. 11 (2003) 1701-1708
6. Dichter M.A., and Brodie M.J. N. Engl. J. Med 334 (1996) 1583-1590
7. Kwan P., and Brodie M.J. CNS Spectr 9 (2004) 110-119
8. Quan Z.S., Wang J.M., Rho J.R., Kwak K.C., Kang H.C., Jun C.S., and Chai K.Y. Bull. Korean Chem. Soc. 26 (2005) 1757-1760
9. Guan L.P., Jin Q.H., Tian G.R., Chi K.Y., and Quan Z.S. J Pharm Pharm Sci. 10 (2007) 254-262
10. Xie Z.F., Chai K.T., Piao H.R., Kwak K.C., and Quan Z.S. Bioorg. Med. Chem. Lett. 15 (2005) 4803-4805
11. Guan L.P., Zhao D.H., Jiang Z., Piao H.R., and Quan Z.S. Pharmazie 64 (2009) 248-251
12. Dawood K.M., Abdel-Gawad H., Rageb E.A., Ellithey M., and Mohamed H.A. Bioorg. Med. Chem. 14 (2006) 3672-3680
13. Moreau S., Coudert P., Rubat C., Vallee-Goyet D., Gardette D., Gramain J.C., and Couquelet J. Bioorg. Med. Chem. 6 (1998) 983-991
14. Mokrab Y., Bavro V.N., Mizuguchi K., Todorov N.P., Martin I.L., Dunn S.M.J., Chan S.L., and Chau P.-L. J Mol Graph Model 26 (2007) 760-774
15. Wang S.Y., Xu P., Zhang C.T., Liang H., Liu W.Q., and Tao C. Journal of Beijing Medical University 21 (1989) 218-220
16. Xu P., Wang S.Y., Tao C., and Liu W.Q. Chinese Journal of Pharmacology and Toxicology 6 (1992) 193-195
17. Xu P., Wang S.Y., Chen Y., Tao C., and Liu W.Q. Acta Pharmaceutica Sinica 26 (1991) 656-659
18. Xiong J.R., Liu Z.C., and Zhang Y.Q. Journal of Sichuan Normal University(Natural Science) 25 (2002) 298-300
19. A. Matsumoto, K. Ishitani, JP 63264575, 1988-11-01 (CA110: 2316523v).
20. Hester Jr. J.B., and Von Voigtlander P. J. Med. Chem. 22 (1979) 1390-1398
21. Hester Jr. J.B., Rudzik A.D., and Von Voigtlander P. J. Med. Chem. 23 (1980) 402-405
22. Okada R., Negishi N., and Nagaya H. Brain Res. 480 (1989) 383-387
23. Olsen R.W. J. Neurochem. 37 (1981) 1-13
24. Kale G. Epilepsia 33 (1992) S3-S12
25. Löscher W. Biochem. Pharmacol. 28 (1979) 1397-1407
26. Krall R.L., Penry J.K., White B.G., Kupferberg H.J., and Swinyard E.A. Epilepsia 19 (1978) 409-428
27. Porter R.J., Cereghino J.J., Gladding G.D., Hessie B.J., Kupferberg H.J., Scoville B., and White B.G. Cleve. Clin. Q 51 (1984) 293-305
28. Bernasconi R., Klein M., Martin P., Christen P., Hafner T., Portet C., and Schmutz M. J. Neural. Transm. 72 (1988) 213-233
29. Arnoldi A., Bonsignori A., Melloni P., Merlini L., Quadri M.L., Rossi A.C., and Valsecchi M. J. Med. Chem. 33 (1990) 2865-2869
30. Löscher W., and Schmidt D. Epilepsy Res. 2 (1988) 145-181