Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models (Pharmazie (2009) 64, (248-251) DOI: 10.1691/ph.2009.8738);Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models

Pharmazie

Volumn 64, Issue 4, 2009, Pages 248-251

  Guan, Li Ping ^a   Zhao, Dong Hai ^b   Jiang, Zhe ^a   Piao, Hu Ri ^a   Quan, Zhe Shan ^a  

^a YANBIAN UNIVERSITY   (China)

^b Institute of Neuroscience   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 MERCAPTOPROPIONIC ACID; 7 HEXYLOXY 5 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOLINE; AMINOTRANSFERASE; CARBAMAZEPINE; GLUTAMATE DECARBOXYLASE; ISONIAZID; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; QUAN 0806; QUINOLINE DERIVATIVE; STRYCHNINE; UNCLASSIFIED DRUG; VALPROIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; 7 HEXYLOXY 5 PHENYL 1,2,4 TRIAZOLO(4,3 ALPHA)QUINOLINE; 7-HEXYLOXY-5-PHENYL-1,2,4-TRIAZOLO(4,3-ALPHA)QUINOLINE; ANTICONVULSIVE AGENT; CONVULSANT AGENT; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ELECTRIC SHOCK; FEMALE; GABAERGIC TRANSMISSION; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; ROTAROD TEST; SEIZURE; ANIMAL; BODY EQUILIBRIUM; BRAIN; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

4-AMINOBUTYRATE TRANSAMINASE; ANIMALS; ANTICONVULSANTS; BRAIN; CONVULSANTS; ELECTROSHOCK; ENZYME ACTIVATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED C57BL; POSTURAL BALANCE; QUINOLINES; SEIZURES; SYNAPTIC TRANSMISSION; TRIAZOLES;

EID: 66449119745     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2009.8814     Document Type: Erratum

References (25)

1. Al-Soud YA, Al-Masoudi NA, Ferwanah AR (2003) Synthesis and properties of new substituted 1,2,4-triazoles: potential antitumor agents. Bioorg Med Chem 8: 1701-1708.
2. Arnoldi A, Bonsignori A, Melloni P, Merlini L, Luisa Quisadri M, Rossi AC, Valsecchi M (1990) Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and benzothiopyrans. J Med Chem 33: 2865-2869.
3. Bernasconi R, Klein M, Martin P, Christen P, Hafner T, Portet C, Schmutz M (1988) Gammavinyl GABA: comparison of neurochemical and anticonvulsant effects in mice. J Neural Transm 72: 213-233.
4. Bourgeois BF (1998) New antiepileptic drugs. Arch Neurol 55: 1181-1183.
5. Gale K (1992) GABA and epilepsy: basic concepts from preclinical research. Epilepsia 33: 3-12.
6. Geurts M, Poupaert JH, Scriba GK, Lambert DM (1998) N-(Benzyloxycarbonyl) glycine esters and amides as new anticonvulsants. J Med Chem 41: 24-30.
7. Guan LP, Sun XY, Tian GR, Chi KY, Quan XS (2008) The synthesis and anticonvulsant activity of 1-substituted-7-methoxy-1,2,4-triazolo[ 4,3-a]quinoline. Turk J Chem 32: 181-189.
8. Hester JB Jr, Von Voigtlander P (1979) 6-Aryl-4H-s-triazolo[4,3-a] [1,4]-benzodiazepines. Influence of 1-substitution on pharmacological activity. J Med Chem 22: 1390-1398.
9. Hester JB Jr, Rudzik AD, von Voigtlander P (1980) 2,4-Dihydro-6-phenyl- 1H-s-triazolo[4,3-a][1,4]benzoidiazepin-1-ones with antianxiety and antidepressant activity. J Med Chem 23: 402-405.
10. Jin HG, Sun XY, Chai KY, Piao HR, Guan ZS (2006) Anticonvulsant and toxicity evaluation of some 7-alkoxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]- quinoline-1(2H)-ones. Bioorg Med Chem 14: 6868-6873.
11. Krall RL, Penry JK, White BG, Kupferberg HJ, Swinyard EA (1978) Antiepileptic drug development: II. Anticonvulsant drug screening. Epilepsia 9: 409-428.
12. Kupferberg HJ (1992) Strategies for identifying and developing new anticonvulsant drugs. Pharm Weekbl Sci 14: 132-138.
13. Leppik IE (1994) Antiepileptic drugs in development: prospects for the near future. Epilepsia 35: 29-40.
14. Lin Z, Kadaba PK (1997) Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents. Med Res Rev 17: 537-572.
15. Löscher W (1979) 3-Mercaptopropionic acid: convulsant properties, effects on enzymes of the gamma-a-minobutyrate system in mouse brain and antagonism by certain anticonvulsant drugs, aminoo-xyacetic acid and gabaculine. Biochem Pharmacol 28: 1397-1407.
16. Löscher W, Nolting B (1991) The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Protective indices. Epilepsy Res 9: 1-10.
17. Löscher W (1998) New visions in the pharmacoloy of anticonvulsion. Eur J Pharmacol 342: 1-13.
18. Okada R, Negishi N, Nagaya H (1989) The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures. Brain Res 480: 383-387.
19. Olsen RW (1981) GABA-benzodiazepine-barbiturate receptor interactions. J Neurochem 37: 1-13.
20. Perucca E (1996) The new generation of antiepileptic drugs: advantages and disadvantages. Br J Clin Pharmacol 42: 531-543.
21. Porter RJ, Cereghino JJ, Gladding GD, Hessie BJ, Kupferberg HJ, Scoville B, White BG (1984) Antiepileptic drug development program. Cleve Clin Q 51: 293-305.
22. Xie ZF, Chai KY, Piao HR, Kwak KC, Quan ZS (2005) Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a] quinolines. Bioorg Med Chem Lett 15: 4803-4805.
23. Sayin U, Cengiz S, Altug T (1993) Vigabatrin as an anticonvulsant against pentylenetetrazol seizures. Pharmacol Res 28: 325-331.
24. Sun XY, Jin YZ, Li FN, Li G, Chai KY, Quan ZS (2006) Synthesis of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and evaluation of their anticonvulsant properties. Arch Pharm Res 29: 1080-1085.
25. Wieland S, Belluzzi J, Hawkinson JE, Hogenkamp D, Upasani R, Stein L, Wood PL, Gee KW, Lan NC (1997) Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593. Psychopharmacology 134: 46-54.