Transplanted neural progenitor cells expressing mutant NT3 promote myelination and partial hindlimb recovery in the chronic phase after spinal cord injury

Biochemical and Biophysical Research Communications

Volumn 393, Issue 4, 2010, Pages 812-817

  Kusano, Kazuo ^a   Enomoto, Mitsuhiro ^a,b   Hirai, Takashi ^a   Tsoulfas, Pantelis ^c   Sotome, Shinichi ^a,b   Shinomiya, Kenichi ^a   Okawa, Atsushi ^a  

^a Tokyo Medical and Dental University ^*  (Japan)

^b Tokyo Medical and Dental University   (Japan)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

Chronic phase; Neural progenitor cells; Neurotrophins; Spinal cord injury; Transplantation

Indexed keywords

ABELSON KINASE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NEUROTROPHIC FACTOR; NEUTROTROPHIN 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; HINDLIMB; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MYELINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; TISSUE INJURY; TISSUE REPAIR;

ANIMALS; BRAIN; GRAFT SURVIVAL; HINDLIMB; HUMANS; MYELIN SHEATH; NERVE REGENERATION; NEURONS; NEUROTROPHIN 3; RATS; RATS, INBRED F344; SPINAL CORD; SPINAL CORD INJURIES; STAINING AND LABELING; STEM CELL TRANSPLANTATION; STEM CELLS; TRANSFECTION;

EID: 77949487367     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.088     Document Type: Article

References (34)

1. Davies A.M., Minichiello L., and Klein R. Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons. EMBO J. 14 (1995) 4482-4489
2. Schröpel A., von Schack D., Dechant G., and Barde Y.A. Early expression of the nerve growth factor receptor ctrkA in chick sympathetic and sensory ganglia. Mol. Cell. Neurosci. 6 (1995) 544-566
3. von Schack D., Casademunt E., Schweigreiter R., Meyer M., Bibel M., and Dechant G. Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat. Neurosci. 4 (2001) 977-978
4. Arvanian V.L., Horner P.J., Gage F.H., and Mendell L.M. Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. J. Neurosci. 23 (2003) 8706-8712
5. Unger T.J., Calderon G.A., Bradley L.C., Sena-Esteves M., and Rios M. Selective deletion of BDNF in the ventromedial and dorsomedical hypothalamus of adult mice results in hyperphagic behavior and obesity. J. Neurosci. 27 (2007) 14265-14274
6. Merighi A., Bardoni R., Salio C., Lossi L., Ferrini F., Prandini M., Zonta M., Gustincich S., and Carmignoto G. Presynaptic functional trkB receptors mediate the release of excitatory neurotransmitters from primary afferent terminals in lamina II (substantia gelatinosa) of postnatal rat spinal cord. Dev. Neurobiol. 68 (2008) 457-475
7. Caporali A., and Emanueli C. Cardiovascular actions of neurotrophins. Physiol. Rev. 89 (2009) 279-308
8. Tuszynski M.H., Murai K., Blesch A., Grill R., and Miller I. Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord. Cell Transplant. 6 (1997) 361-368
9. Tuszynski M.H., Weidner N., McCormack M., Miller I., Powell H., and Conner J. Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination. Cell Transplant. 7 (1998) 187-196
10. Lu P., Jones L.L., and Tuszynski M.H. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp. Neurol. 191 (2005) 344-360
11. Mitsui T., Fischer I., Shumsky J.S., and Murray M. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Exp. Neurol. 194 (2005) 410-431
12. Urfer R., Tsoulfas P., Soppet D., Escandón E., Parada L.F., and Presta L.G. The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin. EMBO J. 13 (1994) 5896-5909
13. Kumar S., Kahn M.A., Dinh L., and de Vellis J. NT-3-mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo. J. Neurosci. Res. 54 (1998) 754-765
14. Bibel M., and Barde Y.A. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14 (2000) 2919-2937
15. Cosgaya J.M., Chan J.R., and Shooter E.M. The neurotrophin receptor p75NTR as a positive modulator of myelination. Science 298 (2002) 1245-1248
16. Cao Q., Xu X.M., Devries W.H., Enzmann G.U., Ping P., Tsoulfas P., Wood P.M., Bunge M.B., and Whittemore S.R. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial restricted precursor cells. J. Neurosci. 25 (2005) 6947-6957
17. Golden K.L., Pearse D.D., Blits B., Garg M.S., Oudega M., Wood P.M., and Bunge M.B. Transduced Schwann cells promote axon growth and myelination after spinal cord injury. Exp. Neurol. 207 (2007) 203-217
18. Grill R.J., Blesch A., and Tuszynski M.H. Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. Exp. Neurol. 148 (1997) 444-452
19. Jin Y., Fischer I., Tessler A., and Houle J.D. Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Exp. Neurol. 177 (2002) 265-275
20. Blits B., Kitay B.M., Farahvar A., Caperton C.V., Dietrich W.D., and Bunge M.B. Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue. Restor. Neurol. Neurosci. 23 (2005) 313-324
21. Follenzi A., and Naldini L. Generation of HIV-1 derived lentiviral vectors. Methods Enzymol. 346 (2002) 454-465
22. Johe K.K., Hazel T.G., Muller T., Dugich-Djordjevic M.M., and McKay R.D. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev. 10 (1996) 3129-3140
23. Basso D.M., Beattie M.S., and Bresnahan J.C. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transaction. Exp. Neurol. 139 (1996) 244-256
24. Lankhorst A.J., Verzijl M.R., and Hamers F.P.T. Experimental spinal cord contusion injury: comparison of different outcome parameters. Neurosci. Res. Commun. 24 (1999) 135-148
25. Popovich P.G., Guan Z., Wei P., Huitinga I., van Rooijen N., and Stokes B.T. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp. Neurol. 158 (1999) 351-365
26. Enzmann G.U., Benton R.L., Talbott J.F., Cao Q., and Whittemore S.R. Functional considerations of stem cell transplantation therapy for spinal cord repair. J. Neurotrauma 23 (2006) 479-495
27. Vroemen M., Aigner L., Winkler J., and Weidner N. Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways. Eur. J. Neurosci. 18 (2003) 743-751
28. Ogawa Y., Sawamoto K., Miyata T., Miyao S., Watanabe M., Nakamura M., Bregman B.S., Koike M., Uchiyama Y., Toyama Y., and Okano H. Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J. Neurosci. Res. 69 (2002) 925-933
29. Cao Q.L., Zhang Y.P., Howard R.M., Walters W.M., Tsoulfas P., and Whittemore S.R. Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage. Exp. Neurol. 167 (2001) 48-58
30. Enomoto M., Shinomiya K., and Okabe S. Migration and differentiation of neural progenitor cells from two different regions of embryonic central nervous system after transplantation into the intact spinal cord. Eur. J. Neurosci. 17 (2003) 1223-1232
31. Widenfalk J., Lundstromer K., Jubran M., Brene S., and Olson L. Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J. Neurosci. 21 (2001) 3457-3475
32. Liebl D.J., Huang W., Young W., and Parada L.F. Regulation of Trk receptors following contusion of the rat spinal cord. Exp. Neurol. 167 (2001) 15-26
33. Notterpek L. Neurotrophins in myelination: a new role for a puzzling receptor. Trends Neurosci. 26 (2003) 232-234
34. Imaizumi T., Lankford K.L., Waxman S.G., Greer C.A., and Kocsis J.D. Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord. J. Neurosci. 18 (1998) 6176-6185