Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat

Journal of Neuroscience

Volumn 23, Issue 25, 2003, Pages 8706-8712

  Arvanian, Victor L ^a   Horner, Philip J ^b   Gage, Fred H ^c   Mendell, Lorne M ^a  

^a Stony Brook University   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Development; Genetically engineered fibroblasts; Motor neuron; Neonatal rat; Neurotrophin; NT 3; Plasticity; Spinal cord; Synaptic transmission

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BETA GALACTOSIDASE; BICUCULLINE; COLLAGEN; KAINIC ACID; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTROPHIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DORSAL ROOT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXCITATORY POSTSYNAPTIC POTENTIAL; FIBROBLAST; GENETIC ENGINEERING; IN VITRO STUDY; MOTONEURON; NERVE CELL PLASTICITY; NERVE FIBER REGENERATION; NERVE POTENTIAL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SYNAPTIC TRANSMISSION; VENTROLATERAL FUNICULUS; WHITE MATTER;

EID: 0141535172     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-25-08706.2003     Document Type: Article

References (38)

1. Arvanian VL, Mendell LM (2001a) Removal of NMDA receptor Mg(2+) block extends the action of NT-3 on synaptic transmission in neonatal rat motoneurons. J Neurophysiol 86:123-129.
2. Arvanian VL, Mendell LM (2001b) Acute modulation of synaptic transmission to motoneurons by BDNF in the neonatal rat spinal cord. Eur J Neurosci 14:1800-1808.
3. Arvanov VL, Seebach BS, Mendell LM (2000) NT-3 evokes an LTP-like facilitation of AMPA/kainate receptor-mediated synaptic transmission in the neonatal rat spinal cord. J Neurophysiol 84:752-758.
4. Arvanov (Arvanian) VL, Horner PJ, Gage FH, Mendell LM (2001) Exposure of neonatal rat spinal cord to genetically engineered NT-3-secreting fibroblasts strengthens descending and afferent synptic connections in motoneurons. Soc Neurosci Abstr 27:905.13.
5. Basso DM (2000) Neuroanatomical substrates of functional recovery after experimental spinal cord injury: implications of basic science research for human spinal cord injury. Phys Ther 80:808-817.
6. Belliveau DJ, Krivko I, Kohn J, Lachance C, Pozniak C, Rusakov D, Kaplan D, Miller FD (1997) NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis. J Cell Biol 136:375-388.
7. Bregman BS, McAtee M, Dai HN, Kuhn PL (1997) Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp Neurol 148:475-494.
8. Buck CR, Seburn KL, Cope TC (2000) Neurotrophin expression by spinal motoneurons in adult and developing rats. J Comp Neurol 416:309-318.
9. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 356:521-523.
10. Davies AM (1996) The neurotrophic hypothesis: where does it stand? Philos Trans R Soc Lond B Biol Sci 351:389-394.
11. Fulton BP, Walton K (1986) Electrophysiologicalproperties of neonatal rat motoneurones studied in vitro. J Physiol (Lond) 370:651-678.
12. Giehl KM, Tetzlaff W (1996) BDNF and NT-3, but not NGF, prevent axotomy-induced death of rat corticospinal neurons in vivo. Eur J Neurosci 8:1167-1175.
13. Giehl KM, Rohrig S, Bonatz H, Gutjahr M, Leiner B, Bartke I, Yan Q, Reichardt LF, Backus C, Welcher AA, Dethleffsen K, Mestres P, Meyer M (2001) Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo. J Neurosci 21:3492-3502.
14. Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH (1997) Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci 17:5560-5572.
15. Horner PJ, Gage FH (2000) Regenerating the damaged central nervous system. Nature 407:963-970.
16. Kawaja MD, Gage FH (1992) Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer 344 rats following striatal implantation. J Comp Neurol 317:102-116.
17. King VR, Michael GJ, Joshi RK, Priestley JV (1999) trkA, trkB, and trkC messenger RNA expression by bulbospinal cells of the rat. Neuroscience 92:935-944.
18. Kirson ED, Schirra C, Konnerth A, Yaari Y (1999) Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells. J Physiol (Lond) 15:99-111.
19. Lindsay RM (1996) Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview. Philos Trans R Soc Lond B Biol Sci 1996 351:365-373.
20. Liu Y, Himes BT, Solowska J, Moul J, Chow SY, Park KI, Tessler A, Murray M, Snyder EY, Fischer I (1999) Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus. Exp Neurol 158:9-26.
21. McMahon SB, Armanini MP, Ling LH, Phillips HS (1994) Expression and co-expression of Trk receptors in subpopulations of adult primary sensory neurons projecting to idenfified peripheral targets. Neuron 12:1161-1171.
22. McTigue DM, Horner PJ, Stokes BT, Gage FH (1998) Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J Neurosci 18:5354-5365.
23. Mendell LM (1995) Neurotrophic factors and the specification of neural function. The Neuroscientist 1:26-34.
24. 2+. Soc Neurosci Abstr 27:262.13.
25. Mendell LM, Johnson RD, Munson JB (1999) Neurotrophin modulation of the monosynaptic reflex after peripheral nerve transection. J Neurosci 19:3162-3170.
26. Mendell LM, Munson JB, Arvanian VL (2001) Neurotrophins and synaptic plasticity in the mammalian spinal cord. J Physiol (Lond) 533:91-97.
27. Menei P, Montero-Menei C, Whittemore SR, Bunge RP, Bunge MB (1998) Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord. Eur J Neurosci 10:607-611.
28. Metz GA, Curt A, van de Meent H, Klusman I, Schwab ME, Dietz V (2000) Validation of the weight-drop contusion model in rats: a comparative study of human spinal cord injury. J Neurotrauma 17:1-17.
29. Peshori KR, Collins WF, Mendell LM (1998) EPSP amplitude modulation at the rat Ia-alpha motoneuron synapse: effects of GABAB receptor agonists and antagonists. J Neurophysiol 79:181-189.
30. Pinco M, Lev-Tov A (1994) Synaptic transmission between ventrolateral funiculus axons and lumbar motoneurones in the isolated spinal cord of the neonatal rat. J Neurophysiol 72:2406-2419.
31. Schnell L, Schneider R, Kolbeck R, Barde YA, Schwab ME (1994) Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature 367:170-173.
32. Seebach BS, Mendell LM (1996) Maturation in properties of motoneurons and their segmental input in the neonatal rat. J Neurophysiol 76:3875-3885.
33. Seebach BS, Arvanov V, Mendell LM (1999) Effects of BDNF and NT-3 on development of Ia/motoneuron functional connectivity in neonatal rats. J Neurophysiol 81:2398-2405.
34. Thomas NK, Hawkins LM, Miller JC, Troop HM, Roberts PJ, Jane DE (1998) Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots. Neuropharmacol 37:1223-1237.
35. Tonra JR, Mendell LM (1997) Rabbit IgG distribution in skin, spinal cord and DRG following systemic injection in rat. J Neuroimmunol 80:97-105.
36. von Meyenburg J, Brosamle C, Metz GA, Schwab ME (1998) Regeneration and sprouting of chronically injured corticospinal tract fibers in adult rats promoted by NT-3 and the mAb IN-1, which neutralizes myelin-associated neurite growth inhibitors. Exp Neurol 154:583-594.
37. Xu XM, Guenard V, Kleitman N, Aebischer P, Bunge MB (1995) A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Exp Neurol 134:261-272.
38. Ziskind-Conhaim L (1990) NMDA receptors mediate poly- and monosynaptic potentials in motoneurons of rat embryos. J Neurosci 10:125-135.