Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 7, 2001, Pages 915-918

  Wilson, Kenneth J ^a   Illig, Carl R ^a   Subasinghe, Nalin ^a   Hoffman, James B ^a   Jonathan Rudolph, M ^a   Soll, Richard ^a   Molloy, Christopher J ^a   Bone, Roger ^a   Green, David ^a   Randall, Troy ^a   Zhang, Marie ^a   Lewandowski, Frank A ^a   Zhou, Zhao ^a   Sharp, Celia ^a   Maguire, Diane ^a   Grasberger, Bruce ^a   DesJarlais, Renee L ^a   Spurlino, John ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOTHIAZOLE DERIVATIVE; 4 (2 AMINO 1,3 THIAZOLYL)THIOPHENE 2 CARBOXAMIDINE DERIVATIVE; AMIDINE; PLASMINOGEN ACTIVATOR INHIBITOR; SERINE PROTEINASE; THIOPHENE 2 CARBOXAMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; BREAST CANCER; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; PROSTATE CANCER;

AMIDINES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; PLASMINOGEN ACTIVATORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIOPHENES; URINARY PLASMINOGEN ACTIVATOR;

EID: 0035832101     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00102-0     Document Type: Article

References (20)

1. Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors
2. Solution-phase libraries for the synthesis of thiazolylthiophene-5-carboxamidines: Preparation of urokinase inhibitors
3. Structure based design and synthesis of 4, 5-disubstituted-thiophen-2-amidines as potent urokinase inhibitors