An improved synthesis of arylboronates toward twenty novel 1,3-disubstituted 4-amino-1H-pyrazolo[3,4-d]pyrimidine analogs

Heterocycles

Volumn 81, Issue 1, 2010, Pages 73-77

  Oikawa, Masato ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

1H Pyrazolo 3,4 d pyrimidine; Arylboronate; Protein Kinase Inhibitor; Suzuki Miyaura Cross Coupling Reaction

Indexed keywords

EID: 77949443496     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/COM-09-11857     Document Type: Article

References (21)

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18. In reference 5, the yield for borylation toward the synthesis of 4c was reported to be 47% yield.
19. Arylboronate 4d was purchased from Wako Pure Chemical Industries, Ltd.
20. 4 (94% yield).
21. Our preliminary biological evaluation has already identified 29 as a selective inhibitor for some Src family tyrosine kinases.