Upregulation of colonic ion channels in APCMin/+ mice

Pflugers Archiv European Journal of Physiology

Volumn 456, Issue 5, 2008, Pages 847-855

  Ousingsawat, Jiraporn ^a   Spitzner, Melanie ^a   Schreiber, Rainer ^a   Kunzelmann, Karl ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Cancer cells; Cell cycle; Colon; Epithelial Na channels; Epithelial transport; Epithelium; K channel

Indexed keywords

ALDOSTERONE; AMILORIDE; APC PROTEIN; EPITHELIAL SODIUM CHANNEL; ION CHANNEL; MAMMALIAN TARGET OF RAPAMYCIN; POTASSIUM CHANNEL; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FLUORESCENCE ANALYSIS; HEMATOCRIT; IN VIVO STUDY; INTESTINAL BLEEDING; INTESTINE TUMOR; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WEIGHT REDUCTION;

ANIMALS; APOPTOSIS; COLON; COLONIC NEOPLASMS; EPITHELIAL SODIUM CHANNEL; GENES, APC; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; ION CHANNELS; MICE; MICE, TRANSGENIC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; SODIUM;

EID: 45649083442     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0451-3     Document Type: Article

References (37)

1. Amasheh S, Barmeyer C, Koch CS, Tavalali S, Mankertz J, Epple HJ, Gehring MM, Florian P, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2004) Cytokine-dependent transcriptional down-regulation of epithelial sodium channel in ulcerative colitis. Gastroenterology 126:1711-1720
2. Aoki K, Tamai Y, Horiike S, Oshima M, Taketo MM (2003) Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 35:323-330
3. Barmeyer C, Harren M, Schmitz H, Heinzel-Pleines U, Mankertz J, Seidler U, Horak I, Wiedenmann B, Fromm M, Schulzke JD (2004) Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation. Am J Physiol Gastrointest Liver Physiol 286:G244-G252
4. Bleich M, Ecke D, Schwartz B, Fraser G, Greger R (1997) Effects of the carcinogen dimethylhydrazine (DMH) on the function of rat colonic crypts. Pflügers Arch 433:254-259
5. Bloch M, Ousingsawat J, Simon R, Gasser TC, Mihatsch MJ, Kunzelmann K, Bubendorf L (2005) KCNMA1 gene amplification promotes tumor cell proliferation in prostate cancer. Oncogene 459:443-447
6. Chae KS, Martin-Caraballo M, Anderson M, Dryer SE (2005) Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons. J Neurophysiol 93:1174-1182
7. Chan AO, Hui WM, Leung G, Tong T, Hung IF, Chan P, Hsu A, But D, Wong BC, Lam SK, Lam KF (2007) Patients with functional constipation do not have increased prevalence of colorectal cancer precursors. Gut 56:451-452
8. Davies RJ, Weidema WF, Sandle GI, Palmer L, Deschner EE, DeCosse JJ (1987) Sodium transport in a mouse model of colonic carcinogenesis. Cancer Res 47:4646-4650
9. Dihlmann S, Kloor M, Fallsehr C, von Knebel DM (2005) Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. Carcinogenesis 26:1503-1512
10. Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Nathke IS (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 176:183-195
11. Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, Breukel C, Alt E, Lipkin M, Khan PM (1994) A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A 91:8969-8973
12. Fodde R, Smits R (2002) Cancer biology. A matter of dosage. Science 298:761-763
13. Kongkanuntn R, Bubb VJ, Sansom OJ, Wyllie AH, Harrison DJ, Clarke AR (1999) Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice. Oncogene 18:7219-7225
14. Kune GA, Kune S, Field B, Watson LF (1988) The role of chronic constipation, diarrhea, and laxative use in the etiology of large-bowel cancer. Data from the Melbourne Colorectal Cancer Study. Dis Colon Rectum 31:507-512
15. Kunzelmann K (2005) Ion channels and cancer. J Membr Biol 205:159-173
16. Land SC, McTavish N, Wilson SM (2007) Modulation of dexamethasone-evoked alpha-ENaC expression by the mammalian target of rapamycin (mTOR). Acta Physiol 189 (S653):P08-L6-14
17. Lastraioli E, Guasti L, Crociani O, Polvani S, Hofmann G, Witchel H, Bencini L, Calistri M, Messerini L, Scatizzi M, Moretti R, Wanke E, Olivotto M, Mugnai G, Arcangeli A (2004) herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells. Cancer Res 64:606-611
18. Lee IA, Dinudom A, Kumar S, Cook DI (2007) Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem 282(41):29866-29873
19. Moran AE, Hunt DH, Javid SH, Redston M, Carothers AM, Bertagnolli MM (2004) Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. J Biol Chem 279:43261-43272
20. Nathke I (2006) Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. Nat Rev Cancer 6:967-974
21. Ousingsawat J, Spitzner M, Puntheeranurak S, Terracciano L, Tornillo L, Bubendorf L, Kunzelmann K, Schreiber R (2007) Expression of voltage gated potassium channels in human and mouse colonic carcinoma. Clin Cancer Res 13:824-831
22. Pardo LA (2004) Voltage-gated potassium channels in cell proliferation. Physiology (Bethesda) 19:285-292
23. + channels. EMBO J 18:5540-5547
24. Puntheeranurak S, Schreiber R, Kunzelmann K, Krishnamra N (2007) Control of ion transport in mouse proximal and distal colon by prolactin. Cell Physiol Biochem 19:77-88
25. Qian CN, Knol J, Igarashi P, Lin F, Zylstra U, The BT, Williams BO (2005) Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem 280:3938-3945
26. Rao CV, Hirose Y, Indranie C, Reddy BS (2001) Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids. Cancer Res 61:1927-1933
27. 2+ signaling, intracellular pH and cell volume in cell proliferation. J Membr Biol 205:129-137
28. Sonnenberg A, Muller AD (1993) Constipation and cathartics as risk factors of colorectal cancer: a meta-analysis. Pharmacology 47(Suppl 1):224-233
29. Sorensen MV, Matos JE, Praetorius HA, Sausbier M, Ruth P, Leipziger J (2005) Aldosterone up-regulates KCA 1.1 (BK) channel-mediated colonic K+ secretion. Acta Physiol 188(S651):P23
30. Spitzner M, Ousingsawat J, Scheidt K, Kunzelmann K, Schreiber R (2007) Role of voltage gated K+ channels for proliferation of colonic cancer cells. FASEB J 21:35-44
31. Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, Gould KA, Dove WF (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256:668-670
32. Valverde MA, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde MI, Mann GE, Vergara C, Latorre R (1999) Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science 285:1929-1931
33. Wasan HS, Novelli M, Bee J, Bodmer WF (1997) Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc Natl Acad Sci U S A 94:3308-3313
34. Weitz J, Koch M, Debus J, Hohler T, Galle PR, Buchler MW (2005) Colorectal cancer. Lancet 365:153-165
35. 2+ influx in carcinoma cells of colon cancer. Life Sci 65:55-62
36. Zhang T, Otevrel T, Gao Z, Gao Z, Ehrlich SM, Fields JZ, Boman BM (2001) Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res 61:8664-8667
37. + channels expressed in HEK293 cells requires basal protein kinase B activity. FEBS Lett 534:125-132