Choosing and preparing antigen-presenting cells

Current Protocols in Immunology

Volumn , Issue SUPPL. 88, 2010, Pages

  Harding, Clifford V ^a   Canaday, David ^a   Ramachandra, Lakshmi ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Antigen processing; Antigen presenting cells; B lymphocytes; Dendritic cells; Macrophages; Monocytes; PBMCs

Indexed keywords

BROMETHOL; CONCANAVALIN A; FLT3 LIGAND; LIPOPOLYSACCHARIDE; PEPTONE;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; B LYMPHOBLAST; B LYMPHOCYTE; BONE MARROW; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CELL LINEAGE; CELL MATURATION; CELL SELECTION; CELL SPECIFICITY; CULTURE MEDIUM; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; LISTERIA MONOCYTOGENES; LUNG LAVAGE; MACROPHAGE; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERITONEAL EXUDATE CELL; PRIORITY JOURNAL; REVIEW; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; B-LYMPHOCYTES; CELL CULTURE TECHNIQUES; DENDRITIC CELLS; HUMANS; IMMUNOLOGIC TECHNIQUES; MACROPHAGES; MICE; RESEARCH DESIGN;

EID: 77949392215     PISSN: 19343671     EISSN: 1934368X     Source Type: Journal    
DOI: 10.1002/0471142735.im1601s23     Document Type: Review

References (62)

1. Ahuja, S.S., 2001. In vitro generation of functional human and murine dendritic cells. Methods Mol. Biol. 156: 67 - 77.
2. Askew, D., Chu, R.S., Krieg, A.M., and, Harding, C.V., 2000. CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen processing mechanisms. J. Immunol. 165: 6889 - 6895.
3. Bakke, O., and, Dobberstein, B., 1990. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 63: 707 - 716.
4. Bancroft, G.J., Bosma, M.J., Bosma, G.C., and, Unanue, E.R., 1986. Regulation of macrophage Ia expression in mice with severe combined immunodeficiency: Induction of Ia expression by a T cell-independent mechanism. J. Immunol. 137: 4 - 9.
5. Beller, D.I., and, Unanue, E.R., 1981. Regulation of macrophage populations. II. Synthesis and expression of Ia antigens by peritoneal exudate macrophages is a transient event. J. Immunol. 126: 263 - 269.
6. Beller, D.I., Kiely, J.-M., and, Unanue, E.R., 1980. Regulation of macrophage populations. I. Preferential induction of Ia-reich peritoneal exudates by immunologic stimuli. J. Immunol. 124: 1426 - 1432.
7. Brasel, K., De Smedt, T., Smith, J.L., and, Maliszewski, C.R., 2000. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood 96: 3029 - 3039.
8. Brunt, L.M., Portnoy, D.A., and, Unanue, E.R., 1990. Presentation of Listeria monocytogenes to CD8 T cells requires secretion of hemolysin and intracellular bacterial growth. J. Immunol. 145: 3540 - 3546.
9. Burgert, H.-G., White, J., Weltzien, H.-U., Marrack, P., and, Kappler, J.W., 1989. Reactivity of V beta 17a CD8 T cell hybrids. Analysis using a new CD8 T cell fusion partner. J. Exp. Med. 170: 1887 - 1904.
10. Canaday, D.H., Gehring, A., Leonard, E.G., Eilertson, B., Schreiber, J.R., Harding, C.V., and, Boom, W.H., 2003. T cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. J. Immunol. Methods 281: 129 - 142.
11. Casten, L A., and, Pierce, S.K., 1988. Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures. J. Immunol. 140: 404 - 410.
12. Chu, R.S., Askew, D., Noss, E.H., Tobian, A., Krieg, A.M., and, Harding, C.V., 1999. CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing. J. Immunol. 163: 1188 - 1194.
13. den Haan, J.M., Lehar, S.M., and, Bevan, M.J., 2000. CD8() but not CD8(-) dendritic cells cross-prime cytotoxic T cells In vivo. J. Exp. Med. 192: 1685 - 1696.
14. Di Pucchio, T., Chatterjee, B., Smed-Sorensen, A., Clayton, S., Palazzo, A., Montes, M., Xue, Y., Mellman, I., Banchereau, J., and, Connolly, J.E., 2008. Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat. Immunol. 9: 551 - 557.
15. Dzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk. M., Miltenyi, S., Buck, D.W., and, Schmitz, J., 2000. BDCA-2, BDCA-3, and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165: 6037 - 6046.
16. Fulton, S.A., Martin, T.D., Redline, R.W., and, Henry Boom, W., 2000. Pulmonary immune responses during primary Mycobacterium bovis- Calmette-Guerin bacillus infection in C57BL/6 mice. Am. J. Respir. Cell. Mol. Biol. 22: 333 - 343.
17. Fulton, S.A., Reba, S.M., Pai, R.K., Pennini, M., Torres, M., Harding, C.V., and, Boom, W.H., 2004. Inhibition of major histocompatibility complex II expression and antigen processing in murine alveolar macrophages by Mycobacterium bovis BCG and the 19-kilodalton mycobacterial lipoprotein. Infect. Immun. 72: 2101 - 2110.
18. Garrigan, K., Moroni-Rawson, P., McMurray, C., Hermans, I., Abernethy, N., Watson, J., and, Ronchese, F., 1996. Functional comparison of spleen dendritic cells and dendritic cells cultured in vitro from bone marrow precursors. Blood 88: 3508 - 3512.
19. Germain, R.N., and, Quill, H., 1986. Unexpected expression of a unique mixed-isotype class II MHC molecule by transfected L cells. Nature 320: 72 - 75.
20. Gilliet, M., Boonstra, A., Paturel, C., Antonenko, S., Xu, X.L., Trinchieri, G., OGarra, A., and, Liu, Y.J., 2002. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 195: 953 - 958.
21. Harding, C.V., and, Geuze, H.J., 1993. Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment. J. Immunol. 151: 3988 - 3998.
22. Hockett, R.D., Cook, J.R., Findlay, K., and, Harding, C.V., 1996. Interferon-γ differentially regulates antigen processing functions in distinct endocytic compartments of macrophages with constitutive expression of class II MHC molecules. Immunology 87: 68 - 75.
23. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., and, Steinman, R.M., 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176: 1693 - 1702.
24. Jefford, M., Schnurr, M., Toy, T., Masterman, K.A., Shin, A., Beecroft, T., Tai, T.Y., Shortman, K., Shackleton, M., Davis, I.D., Parente, P., Luft, T., Chen, W., Cebon, J., and, Maraskovsky, E., 2003. Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: Differential regulation of function by specific classes of physiologic stimuli. Blood 102: 1753 - 1763.
25. Jones, L., McDonald, D., and, Canaday, D.H., 2007. Rapid MHC-II antigen presentation of HIV type 1 by human dendritic cells. AIDS Res. Hum. Retroviruses 23: 812 - 816.
26. Kim, S.J., and, Diamond, B., 2007. Generation and maturation of bone marrow-derived DCs under serum-free conditions. J. Immunol. Methods 323: 101 - 108.
27. Labeur, M.S., Roters, B., Pers, B., Mehling, A., Luger, T.A., Schwarz, T., and, Grabbe, S., 1999. Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage. J. Immunol. 162: 168 - 175.
28. Lamb, C.A., Yewdell, J.W., Bennink, J.R., and, Cresswell, P., 1991. Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus. Proc. Natl. Acad. Sci. U.S.A. 88: 5998 - 6002.
29. Lanzavecchia, A., 1990. Receptor-mediated antigen uptake and its effect on antigen presentation to class-II-restricted T lymphocytes. Ann. Rev. Immunol. 8: 773 - 793.
30. Lotteau, V., Teyton, L., Peleraux, A., Nilsson, T., Karlsson, L., Schmid, S.L., Quaranta, V., and, Peterson, P.A., 1990. Intracellular transport of class II MHC molecules directed by invariant chain. Nature 348: 600 - 605.
31. Lu, L., McCaslin, D., Starzl, T.E., and, Thomson, A.W., 1995a. Bone marrow-derived dendritic cell progenitors (NLDC 145, MHC class II, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 60: 1539 - 1545.
32. Lu, L., Rudert, W.A., Qian, S., McCaslin, D., Fu, F., Rao, A.S., Trucco, M., Fung. J.J., Starzl, T.E., and, Thomson, A.W., 1995b. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 182: 379 - 387.
33. Luft, T., Pang, K.C., Thomas, E., Bradley, C.J., Savoia, H., Trapani, J., and, Cebon, J., 1998. A serum-free culture model for studying the differentiation of human dendritic cells from adult CD34 progenitor cells. Exp. Hematol. 26: 489 - 500.
34. Lutz, M.B., and, Rossner, S., 2007. Factors influencing the generation of murine dendritic cells from bone marrow: The special role of fetal calf serum. Immunobiology 212: 855 - 862.
35. Lutz, M.B., Kukutsch, N., Ogilvie, A.L., Rossner, S., Koch, F., Romani, N., and, Schuler, G., 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223: 77 - 92.
36. Lutz, M.B., Schnare, M., Menges, M., Rossner, S., Rollinghoff, M., Schuler, G., and, Gessner, A., 2002. Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF. J. Immunol. 169: 3574 - 3580.
37. Maraskovsky, E., Brasel, K., Teepe, M., Roux, E.R., Lyman, S.D., Shortman, K., and, McKenna, H.J., 1996. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified. J. Exp. Med. 184: 1953 - 1962.
38. Mayordomo, J.I., Zorina, T., Storkus, W.J., Zitvogel, L., Garcia-Prats, M.D., DeLeo, A.B., and, Lotze, M.T., 1997. Bone marrow-derived dendritic cells serve as potent adjuvants for peptide-based antitumor vaccines. Stem Cells 15: 94 - 103.
39. Naik, S.H., Proietto, A.I., Wilson, N.S., Dakic, A., Schnorrer, P., Fuchsberger, M., Lahoud, M.H., OKeeffe, M., Shao, Q.X., Chen, W.F., Villadangos, J.A., Shortman, K., and, Wu, L., 2005. Cutting edge: Generation of splenic CD8 and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J. Immunol. 174: 6592 - 6597.
40. Noss, E.H., Pai, R.K., Sellati, T.J., Radolf, J.D., Belisle, J., Golenbock, D.T., Boom, W.H., and, Harding, C.V., 2001. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19 kD lipoprotein of Mycobacterium tuberculosis. J. Immunol. 167: 910 - 918.
41. Peterson, M., and, Miller, J., 1992. Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41. Nature 357: 596 - 598.
42. Pfeifer, J.D., Wick, M.J., Roberts, R.L., Findlay, K.F., Normark, S.J., and, Harding, C.V., 1993. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 361: 359 - 362.
43. Pooley, J.L., Heath, W.R., and, Shortman, K., 2001. Cutting edge: Intravenous soluble antigen is presented to cd4 t cells by cd8(-) dendritic cells, but cross-presented to cd8 t cells by cd8() dendritic cells. J. Immunol. 166: 5327 - 5330.
44. Ramachandra, L., Noss, E., Boom, W.H., and, Harding, C.V., 2001. Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation. J. Exp. Med. 194: 1421 - 1432.
45. Sallusto, F., and, Lanzavecchia, A., 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109 - 1118.
46. Scheicher, C., Mehlig, M., Zecher, R., and, Reske, K., 1992. Dendritic cells from mouse bone marrow: In vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor. J. Immunol. Methods 154: 253 - 264.
47. Sekaly, R.P., Tonelle, C., Strubin, M., Mach, B., and, Long, E.O., 1986. Cell surface expression of class II histocompatibillity antigens occurs in the absence of the invariant chain. J. Exp. Med. 164: 1490 - 1504.
48. Shortman, K., and, Liu, Y.J., 2002. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2: 151 - 161.
49. Shortman, K., and, Naik, S.H., 2007. Steady-state and inflammatory dendritic-cell development. Nat. Rev. Immunol. 7: 19 - 30.
50. Song, R., and, Harding, C.V., 1996. Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway. J. Immunol. 156: 4182 - 4190.
51. Stockinger, B., Pessara, U., Lin, R.H., Habicht, J., Grez, M., and, Koch, N., 1989. A role of Ia-associated invariant chains in antigen processing and presentation. Cell 56: 683 - 689.
52. Thurner, B., Roder, C., Dieckmann, D., Heuer, M., Kruse, M., Glaser, A., Keikavoussi, P., Kampgen, E., Bender, A., and, Schuler, G., 1999. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J. Immunol. Methods 223: 1 - 15.
53. Torres, M., Ramachandra, L., Rojas, R.E., Bobadilla, K., Thomas, J., Canaday, D.H., Harding, C.V., and, Boom, W.H., 2006. Role of phagosomes and major histocompatibility complex class II (MHC-II) compartment in MHC-II antigen processing of Mycobacterium tuberculosis in human macrophages. Infect. Immun. 74: 1621 - 1630.
54. Uchida, T., Ju, S.-T., Fay, A., Liu, Y.-N., and, Dorf, M.E., 1985. Functional analysis of macrophage hybridomas. I. Production and initial characterization. J. Immunol. 134: 772 - 778.
55. Van Kaer, L., Aston-Rickardt, P.G., Ploegh, H.L., and, Tonegawa, S., 1992. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules and CD4-8 T cells. Cell 71: 1205 - 1214.
56. Van Kaer, L., Ashton-Rickardt, P.G., Eichelberger, M., Gaczynska, M., Nagashima, K., Rock, K.L., Goldberg, A.L., Doherty, P.C., and, Tonegawa, S., 1994. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity 1: 533 - 541.
57. Vremec, D., and, Shortman, K., 1997. Dendritic cell subtypes in mouse lymphoid organs: Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J. Immunol. 159: 565 - 573.
58. Vremec, D., Pooley, J., Hochrein, H., Wu, L., and, Shortman, K., 2000. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 164: 2978 - 2986.
59. Winzler, C., Rovere, P., Rescigno, M., Granucci, F., Penna, G., Adorini, L., Zimmermann, V.S., Davoust, J., and, Ricciardi-Castagnoli, P., 1997. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. 185: 317 - 328.
60. Wirsing von Koenig, C. H., and, Finger, H., 1982. Failure of killed Listeria monocytogenes vaccine to produce protective immunity. Nature 297: 233 - 234.
61. Xu, Y., Zhan, Y., Lew, A.M., Naik, S.H., and, Kershaw, M.H., 2007. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J. Immunol. 179: 7577 - 7584.
62. Zheng, Z., Takahashi, M., Narita, M., Toba, K., Liu, A., Furukawa, T., Koike, T., and, Aizawa, Y., 2000. Generation of dendritic cells from adherent cells of cord blood by culture with granulocyte-macrophage colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha. J. Hematother. Stem Cell Res. 9: 453 - 464.