Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins

Journal of Virology

Volumn 84, Issue 7, 2010, Pages 3476-3487

  Everett, Roger D ^a   Boutell, Chris ^a   McNair, Carol ^a   Grant, Louise ^a   Orr, Anne ^a  

^a INSTITUTE OF VIROLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ETICYCLIDINE; IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN ICP0; TETRACYCLINE; UNCLASSIFIED DRUG;

ARTICLE; BOVINE HERPES VIRUS; CONTROLLED STUDY; EQUINE HERPES VIRUS; HERPES VIRUS; IMMUNOFLUORESCENCE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDORABIES HERPETOVIRUS; VARICELLA ZOSTER VIRUS; VIRUS GENOME; VIRUS REPLICATION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, NUCLEAR; AUTOANTIGENS; CELL LINE; GENOME, VIRAL; HERPESVIRUS 1, BOVINE; HERPESVIRUS 1, HUMAN; HERPESVIRUS 1, SUID; HERPESVIRUS 3, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VIRAL PROTEINS;

BOVINAE; EQUID HERPESVIRUS 1; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 3; SUID HERPESVIRUS 1;

EID: 77949381185     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02544-09     Document Type: Article

References (79)

1. Barlow, P. N., B. Luisi, A. Milner, M. Elliott, and R. Everett. 1994. Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-finger. J. Mol. Biol. 237:201-211.
2. Boldogkoi, Z., A. Braun, and I. Fodor. 2000. Replication and virulence of early protein 0 and long latency transcript deficient mutants of the Aujeszky's disease (pseudorabies) virus. Microbes Infect. 2:1321-1328.
3. Boutell, C., S. Sadis, and R. D. Everett. 2002. Herpes simplex virus type 1 immediate-early protein ICP0 and its isolated RING finger domain act as ubiquitin E3 ligases in vitro. J. Virol. 76:841-850.
4. Bowles, D. E., V. R. Holden, Y. Zhao, and D. J. O'Callaghan. 1997. The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters. J. Virol. 71:4904-4914.
5. Bowles, D. E., S. K. Kim, and D. J. O'Callaghan. 2000. Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein. J. Virol. 74:1200-1208.
6. Brukman, A., and L. W. Enquist. 2006. Pseudorabies virus EP0 protein counteracts an interferon-induced antiviral state in a species-specific manner. J. Virol. 80:10871-10873.
7. Brukman, A., and L. W. Enquist. 2006. Suppression of the interferon-mediated innate immune response by pseudorabies virus. J. Virol. 80:6345-6356.
8. Cabirac, G. F., R. Mahalingam, M. Wellish, and D. H. Gilden. 1990. Transactivation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62. Virus Res. 15:57-68.
9. Canning, M., C. Boutell, J. Parkinson, and R. D. Everett. 2004. A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. J. Biol. Chem. 279:38160-38168.
10. Chee, A. V., and B. Roizman. 2004. Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites. J. Virol. 78:4185-4196.
11. Cheung, A. K., J. Fang, and R. D. Wesley. 1994. Characterization of a pseudorabies virus that is defective in the early protein 0 and latency genes. Am. J. Vet. Res. 55:1710-1716.
12. Cohen, J. I., and H. Nguyen. 1998. Varicella-zoster virus ORF61 deletion mutants replicate in cell culture, but a mutant with stop codons in ORF61 reverts to wild-type virus. Virology 246:306-316.
13. Diao, L., B. Zhang, J. Fan, X. Gao, S. Sun, K. Yang, D. Xin, N. Jin, Y. Geng, and C. Wang. 2005. Herpes virus proteins ICP0 and BICP0 can activate NF-κB by catalyzing IκBα ubiquitination. Cell Signal. 17:217-229.
14. Eidson, K. M., W. E. Hobbs, B. J. Manning, P. Carlson, and N. A. DeLuca. 2002. Expression of herpes simplex virus ICP0 inhibits the induction of interferon-stimulated genes by viral infection. J. Virol. 76:2180-2191.
15. Everett, R., A. Orr, and M. Elliott. 1995. The equine herpesvirus 1 gene 63 RING finger protein partially complements Vmw110, its herpes simplex virus type 1 counterpart. J. Gen. Virol. 76:2369-2374.
16. Everett, R. D. 1989. Construction and characterization of herpes simplex virus type 1 mutants with defined lesions in immediate early gene 1. J. Gen. Virol. 70:1185-1202.
17. Everett, R. D. 2000. ICP0, a regulator of herpes simplex virus during lytic and latent infection. Bioessays 22:761-770.
18. Everett, R. D. 2006. The roles of ICP0 during HSV-1 infection, p. 39-64. In R. M. Sandri-Goldin (ed.), Alpha herpesviruses: molecular and cellular biology. Caister Academic Press, Wymondham, United Kingdom.
19. Everett, R. D., A. Cross, and A. Orr. 1993. A truncated form of herpes simplex virus type 1 immediate-early protein Vmw110 is expressed in a cell type dependent manner. Virology 197:751-756.
20. Everett, R. D., W. C. Earnshaw, J. Findlay, and P. Lomonte. 1999. Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110. EMBO J. 18:1526-1538.
21. Everett, R. D., P. Freemont, H. Saitoh, M. Dasso, A. Orr, M. Kathoria, and J. Parkinson. 1998. The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoforms. J. Virol. 72:6581-6591.
22. Everett, R. D., and J. Murray. 2005. ND10 components relocate to sites associated with herpes simplex virus type 1 nucleoprotein complexes during virus infection. J. Virol. 79:5078-5089.
23. Everett, R. D., J. Murray, A. Orr, and C. M. Preston. 2007. Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts. J. Virol. 81:10991-11004.
24. Everett, R. D., and A. Orr. 2009. Herpes simplex virus type 1 regulatory protein ICP0 aids infection in cells with a preinduced interferon response but does not impede interferon-induced gene induction. J. Virol. 83:4978-4983.
25. Everett, R. D., C. Parada, P. Gripon, H. Sirma, and A. Orr. 2008. Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100. J. Virol. 82:2661-2672.
26. Everett, R. D., M. L. Parsy, and A. Orr. 2009. Analysis of the functions of herpes simplex virus type 1 regulatory protein ICP0 that are critical for lytic infection and derepression of quiescent viral genomes. J. Virol. 83:4963-4977.
27. Everett, R. D., S. Rechter, P. Papior, N. Tavalai, T. Stamminger, and A. Orr. 2006. PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. J. Virol. 80:7995-8005.
28. Everett, R. D., D. F. Young, R. E. Randall, and A. Orr. 2008. STAT-1- and IRF-3-dependent pathways are not essential for repression of ICP0-null mutant herpes simplex virus type 1 in human fibroblasts. J. Virol. 82:8871-8881.
29. Fraefel, C., J. Zeng, Y. Choffat, M. Engels, M. Schwyzer, and M. Ackermann. 1994. Identification and zinc dependence of the bovine herpesvirus 1 transactivator protein BICP0. J. Virol. 68:3154-3162.
30. Geiser, V., Y. Zhang, and C. Jones. 2005. Analysis of a bovine herpesvirus 1 recombinant virus that does not express the bICP0 protein. J. Gen. Virol. 86:1987-1996.
31. Geoffroy, M. C., G. Chadeuf, A. Orr, A. Salvetti, and R. D. Everett. 2006. Impact of the interaction between herpes simplex virus type 1 regulatory protein ICP0 and ubiquitin-specific protease USP7 on activation of adeno-associated virus type 2 rep gene expression. J. Virol. 80:3650-3654.
32. Gripon, P., S. Rumin, S. Urban, J. Le Seyec, D. Glaise, I. Cannie, C. Guyomard, J. Lucas, C. Trepo, and C. Guguen-Guillouzo. 2002. Infection of a human hepatoma cell line by hepatitis B virus. Proc. Natl. Acad. Sci. U. S. A. 99:15655-15660.
33. Hagglund, R., and B. Roizman. 2004. Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1. J. Virol. 78:2169-2178.
34. Halford, W. P., C. Weisend, J. Grace, M. Soboleski, D. J. Carr, J. W. Balliet, Y. Imai, T. P. Margolis, and B. M. Gebhardt. 2006. ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virol. J. 3:44.
35. Harle, P., B. Sainz, Jr., D. J. Carr, and W. P. Halford. 2002. The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/beta. Virology 293:295-304.
36. Harris, R. A., R. D. Everett, X. X. Zhu, S. Silverstein, and C. M. Preston. 1989. Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system. J. Virol. 63:3513-3515.
37. Henderson, G., Y. Zhang, and C. Jones. 2005. The Bovine herpesvirus 1 gene encoding infected cell protein 0 (bICP0) can inhibit interferon-dependent transcription in the absence of other viral genes. J. Gen. Virol. 86:2697-2702.
38. Ho, T. Y., S. L. Wu, T. J. Chang, C. H. Hsiang, S. H. Chang, and C. Y. Hsiang. 1999. Pseudorabies virus early protein 0 trans-activates the TATA-associated promoter by stimulating the transcription initiation. Virus Res. 61:77-86.
39. Hobbs, W. E., II, and N. A. DeLuca. 1999. Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0. J. Virol. 73:8245-8255.
40. Hobbs, W. E., D. E. Brough, I. Kovesdi, and N. A. DeLuca. 2001. Efficient activation of viral genomes by levels of herpes simplex virus ICP0 insufficient to affect cellular gene expression or cell survival. J. Virol. 75:3391-3403.
41. Inman, M., Y. Zhang, V. Geiser, and C. Jones. 2001. The zinc ring finger in the bICP0 protein encoded by bovine herpesvirus-1 mediates toxicity and activates productive infection. J. Gen. Virol. 82:483-492.
42. Jamieson, D. R., L. H. Robinson, J. I. Daksis, M. J. Nicholl, and C. M. Preston. 1995. Quiescent viral genomes in human fibroblasts after infection with herpes simplex virus type 1 Vmw65 mutants. J. Gen. Virol. 76:1417-1431.
43. Joazeiro, C. A., and A. M. Weissman. 2000. RING finger proteins: mediators of ubiquitin ligase activity. Cell 102:549-552.
44. Johnson, P. A., M. J. Wang, and T. Friedmann. 1994. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J. Virol. 68:6347-6362.
45. Kim, S. K., D. E. Bowles, and D. J. O'Callaghan. 1999. The γ2 late glycoprotein K promoter of equine herpesvirus 1 is differentially regulated by the IE and EICP0 proteins. Virology 256:173-179.
46. Koppel, R., C. Fraefel, B. Vogt, L. J. Bello, W. C. Lawrence, and M. Schwyzer. 1996. Recombinant bovine herpesvirus-1 (BHV-1) lacking transactivator protein BICPO entails lack of glycoprotein C and severely reduced infectivity. Biol. Chem. 377:787-795.
47. Kyratsous, C. A., and S. J. Silverstein. 2009. Components of nuclear domain 10 bodies regulate varicella-zoster virus replication. J. Virol. 83:4262-4274.
48. Kyratsous, C. A., M. S. Walters, C. A. Panagiotidis, and S. J. Silverstein. 2009. Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p. J. Virol. 83:10637-10643.
49. Leib, D. A., T. E. Harrison, K. M. Laslo, M. A. Machalek, N. J. Moorman, and H. W. Virgin. 1999. Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo. J. Exp. Med. 189:663-672.
50. Lukashchuk, V., and R. D. Everett. Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx. J. Virol., in press.
51. Melroe, G. T., N. A. DeLuca, and D. M. Knipe. 2004. Herpes simplex virus 1 has multiple mechanisms for blocking virus-induced interferon production. J. Virol. 78:8411-8420.
52. Moriuchi, H., M. Moriuchi, and J. I. Cohen. 1994. The RING finger domain of the varicella-zoster virus open reading frame 61 protein is required for its transregulatory functions. Virology 205:238-246.
53. Moriuchi, H., M. Moriuchi, H. Dean, A. K. Cheung, and J. I. Cohen. 1995. Pseudorabies virus EPO is functionally homologous to varicella-zoster virus ORF61 protein and herpes simplex virus type 1 ICPO. Virology 209:281-283.
54. Moriuchi, H., M. Moriuchi, H. A. Smith, S. E. Straus, and J. I. Cohen. 1992. Varicella-zoster virus open reading frame 61 protein is functionally homologous to herpes simplex virus type 1 ICP0. J. Virol. 66:7303-7308.
55. Moriuchi, H., M. Moriuchi, S. E. Straus, and J. I. Cohen. 1993. Varicellazoster virus (VZV) open reading frame 61 protein transactivates VZV gene promoters and enhances the infectivity of VZV DNA. J. Virol. 67:4290-4295.
56. Mossman, K. L., P. F. Macgregor, J. J. Rozmus, A. B. Goryachev, A. M. Edwards, and J. R. Smiley. 2001. Herpes simplex virus triggers and then disarms a host antiviral response. J. Virol. 75:750-758.
57. Mossman, K. L., H. A. Saffran, and J. R. Smiley. 2000. Herpes simplex virus ICP0 mutants are hypersensitive to interferon. J. Virol. 74:2052-2056.
58. Mossman, K. L., and J. R. Smiley. 2002. Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication. J. Virol. 76:1995-1998.
59. Negorev, D. G., O. V. Vladimirova, A. Ivanov, F. Rauscher, 3rd, and G. G. Maul. 2006. Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression. J. Virol. 80:8019-8029.
60. Ono, E., S. Watanabe, H. Nikami, T. Tasaki, and H. Kida. 1998. Pseudorabies virus (PRV) early protein 0 activates PRV gene transcription in combination with the immediate-early protein IE180 and enhances the infectivity of PRV genomic DNA. Vet. Microbiol. 63:99-107.
61. Parkinson, J., and R. D. Everett. 2000. Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 affect cellular structures and proteins. J. Virol. 74:10006-10017.
62. Parkinson, J., and R. D. Everett. 2001. Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 induce the formation of colocalizing, conjugated ubiquitin. J. Virol. 75:5357-5362.
63. Preston, C. M., and M. J. Nicholl. 2005. Human cytomegalovirus tegument protein pp71 directs long-term gene expression from quiescent herpes simplex virus genomes. J. Virol. 79:525-535.
64. Reichelt, M., J. Brady, and A. M. Arvin. 2009. The replication cycle of varicella-zoster virus: analysis of the kinetics of viral protein expression, genome synthesis, and virion assembly at the single-cell level. J. Virol. 83: 3904-3918.
65. Saira, K., S. Chowdhury, N. Gaudreault, L. da Silva, G. Henderson, A. Doster, and C. Jones. 2008. The zinc RING finger of bovine herpesvirus 1-encoded bICP0 protein is crucial for viral replication and virulence. J. Virol. 82:12060-12068.
66. Saira, K., Y. Zhou, and C. Jones. 2009. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. J. Virol. 83: 3977-3981.
67. Saira, K., Y. Zhou, and C. Jones. 2007. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) induces degradation of interferon response factor 3 and, consequently, inhibits beta interferon promoter activity. J. Virol. 81:3077-3086.
68. Samaniego, L. A., N. Wu, and N. A. DeLuca. 1997. The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27. J. Virol. 71: 4614-4625.
69. Showalter, S. D., M. Zweig, and B. Hampar. 1981. Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4. Infect. Immun. 34:684-692.
70. Steinmann, N. A., R. Nunez, R. Koppel, and M. Ackermann. 1998. Construction and characterization of a stably transformed HeLa cell line in which the expression of bovine herpesvirus 1 ICP0 (BICP0) is induced by tetracycline. Arch. Virol. 143:35-48.
71. Sternsdorf, T., H. H. Guldner, C. Szostecki, T. Grotzinger, and H. Will. 1995. Two nuclear dot-associated proteins, PML and Sp100, are often co-autoimmunogenic in patients with primary biliary cirrhosis. Scand. J. Immunol. 42:257-268.
72. Stow, N. D., and E. C. Stow. 1986. Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw110. J. Gen. Virol. 67:2571-2585.
73. Stuurman, N., A. de Graaf, A. Floore, A. Josso, B. Humbel, L. de Jong, and R. van Driel. 1992. A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies. J. Cell Sci. 101:773-784.
74. Thompson, R. L., and N. M. Sawtell. 2006. Evidence that the herpes simplex virus type 1 ICP0 protein does not initiate reactivation from latency in vivo. J. Virol. 80:10919-10930.
75. Wang, L., M. Sommer, J. Rajamani, and A. M. Arvin. 2009. Regulation of the ORF61 promoter and ORF61 functions in varicella-zoster virus replication and pathogenesis. J. Virol. 83:7560-7572.
76. Watanabe, S., E. Ono, Y. Shimizu, and H. Kida. 1996. Mapping of transregulatory domains of pseudorabies virus early protein 0 and identification of its dominant-negative mutant. Arch. Virol. 141:1001-1009.
77. Watanabe, S., E. Ono, Y. Shimizu, and H. Kida. 1995. Pseudorabies virus early protein 0 transactivates the viral gene promoters. J. Gen. Virol. 76: 2881-2885.
78. Yao, H., N. Osterrieder, and D. J. O'Callaghan. 2003. Generation and characterization of an EICP0 null mutant of equine herpesvirus 1. Virus Res. 98:163-172.
79. Zhang, Y., J. Zhou, and C. Jones. 2005. Identification of functional domains within the bICP0 protein encoded by bovine herpesvirus 1. J. Gen. Virol. 86:879-886.