Propolis inhibits the proliferation of human leukaemia HL-60 cells by inducing apoptosis through the mitochondrial pathway

Natural Product Research

Volumn 24, Issue 4, 2010, Pages 375-386

  Eom, Hyeon Soo ^a   Lee, Eun Jee ^a   Yoon, Byong Su ^a   Yoo, Byung Sun ^a  

^a Kyonggi University   (South Korea)

Author keywords

Apoptosis; Caspase 3; Cytochrome c; HL 60; PARP; Propolis

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CASPASE 3; CYTOCHROME C; GENOMIC DNA; PROPOLIS;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN HL 60; CYTOSOL; DNA FRAGMENTATION; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL PROLIFERATION; CYTOCHROMES C; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; MITOCHONDRIA; PROPOLIS;

EID: 77949352942     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786410903370908     Document Type: Article

References (42)

1. Adams, J.M., & Cory, S. (1998). The Bcl-2 protein family: Arbiters of cell survival. Science, 281(5381), 1322-1326.
2. Ahn, M.R., Kunimasa, K., Ohta, T., Kumazawa, S., Kamihira, M., Kaji, K., et al. (2007). Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Letters, 252(2), 235-243.
3. Bankova, V. (2005). Chemical diversity of propolis and the problem of standardization. Journal of Ethnopharmacology, 100(1-2), 114-117.
4. Banskota, A.H., Tezuka, Y., & Kadota, S. (2001a). Recent progress in pharmacological research of propolis. Phytotherapy Research, 15(7), 561-571.
5. Banskota, A.H., Tezuka, Y., Adnyana, I.K., Ishii, E., Midorikawa, K., Matsushige, K., et al. (2001b). Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis. Phytomedicine, 8(1), 16-23.
6. Boulares, A.H., Yakovlev, A.G., Ivanova, V., Stoica, B.A., Wang, G., Iyer, S., et al. (1999). Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Journal of Biological Chemistry, 274(33), 22932-22940.
7. Burdock, G.A. (1998). Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology, 36(4), 347-363.
8. Chen, C.N., Wu, C.L., & Lin, J.K. (2007). Apoptosis of human melanoma cells induced by the novel compounds propolin A and propolin B from Taiwanese propolis. Cancer Letters, 245(1-2), 218-231.
9. Chen, C.N., Weng, M.S., Wu, C.L., & Lin, J.K. (2004). Comparison of radical scavenging activity, cytotoxic effects and apoptosis induction in human melanoma cells by Taiwanese propolis from different sources. Evidence-based Complementary and Alternative Medicine, 1(2), 175-185.
10. Chen, C.N., Wu, C.L., Shy, H.S., & Lin, J.K. (2003). Cytotoxic prenylflavanones from Taiwanese propolis. Journal of Natural Products, 66(4), 503-506.
11. Cohen, G.M. (1997). Caspases: The executioners of apoptosis. Biochemical Journal, 326, 1-16.
12. Desagher, S., & Martinou, J.C. (2000). Mitochondria as the central control point of apoptosis. Trends in Cell Biology, 10(9), 369-377.
13. Earnshaw, W.C., Martins, L.M., & Kaufmann, S.H. (1999). Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annual Review of Biochemistry, 68, 383-424.
14. Frankfurt, O.S., & Krishan, A. (2003). Apoptosis-based drug screening and detection of selective toxicity to cancer cells. Anti-cancer Drugs, 14(7), 555-561.
15. Ghisalberti, E. (1979). Propolis: A review. Bee World, 60, 59-84.
16. Gollapudi, L., & Oblinger, M.M. (1999). Estrogen and NGF synergistically protect terminally differentiated, ERalpha-transfected PC12 cells from apoptosis. Journal of Neuroscience Research, 56(5), 471-481.
17. Green, D.R., & Reed, J.C. (1998). Mitochondria and apoptosis. Science, 281(5381), 1309-1312.
18. Green, P.S., Gridley, K.E., & Simpkins, J.W. (1996). Estradiol protects against betaamyloid( 25-35) induced toxicity in SK-N-SH human neuroblastoma cells. Neuroscience Letters, 218(3), 165-168.
19. Heim, K.E., Tagliaferro, A.R., & Bobilya, A.R. (2002). Flavonoid antioxidants: Chemistry, metabolism and structure activity relationships. Journal of Nutritional Biochemistry, 13(10), 572-584.
20. Hotti, A., Jarvinen, K., Siivola, P., & Holtta, E. (2000). Caspases and mitochondria in c-Mycinduced apoptosis: Identification of ATM as a new target of caspases. Oncogene, 19(19), 2354-2362.
21. Janicke, R.U., Sprengart, M.L., Wati, M.R., & Porter, A.G. (1998). Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. Journal of Biological Chemistry, 273(16), 9357-9360.
22. Jiang, X., & Wang, X. (2004). Cytochrome c-mediated apoptosis. Annual Review of Biochemistry, 73, 87-106.
23. Kujumgiev, A., Tsvetkova, I., Serkedjieva, Y., Bankova, V., Christov, R., & Popov, S. (1999). Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. Journal of Ethnopharmacology, 64(3), 235-240.
24. Ledon, N., Casaco, A., Gonzalez, R., Merino, N., Gonzalez, A., & Tolon, Z. (1997). Antipsoriatic, anti-inflammatory, and analgesic effects of an extract of red propolis. Acta Pharmacologica Sinica, 18(3), 274-276.
25. Lippke, J.A., Gu, Y., Sarnecki, C., Caron, P.R., & Su, M.S. (1996). Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. Journal of Biological Chemistry, 271(4), 1825-1828.
26. Liu, G.A., & Zheng, R.L. (2002). Protection against damaged DNA in the single cell by polyphenols. Pharmazie, 57(12), 852-854.
27. Los, M., Mozoluk, M., Ferrari, D., Stepczynska, A., Stroh, C., Renz, A., et al. (2002). Activation and caspase-mediated inhibition of PARP: A molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Molecular Biology of the Cell, 13(3), 978-988.
28. Matsushige, K., Basnet, P., Hase, K., Kadota, S., Tanaka, K., & Namba, T. (1996). Propolis protects pancreatic--cells against the toxicity of streptozotocin (STZ). Phytomedicine, 3, 203-209.
29. Mishima, S., Narita, Y., Chikamatsu, S., Inoh, Y., Ohta, S., Yoshida, C., et al. (2005). Effects of propolis on cell growth and gene expression in HL-60 cells. Journal of Ethnopharmacology, 99(1), 5-11.
30. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55-63.
31. Mohammadzadeh, S., Sharriatpanahi, M., Hamedi, M., Amanzadeh, Y., Sadat Ebrahimi, S.E., & Ostad, S.N. (2007). Antioxidant power of Iranian propolis extract. Food Chemistry, 103, 729-733.
32. Orsolić , N., & Basić , I. (2003). Immunomodulation by water-soluble derivative of propolis: A factor of antitumor reactivity. Journal of Ethnopharmacology, 84(2-3), 265-273.
33. Orsolic, N., Benkovic, V., Horvat-Knezevic, A., Kopjar, N., Kosalec, I., Bakmaz, M., et al. (2007). Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds. Biological & Pharmaceutical Bulletin, 30(5), 946-951.
34. Reed, J.C. (2001). Apoptosis-regulating proteins as targets for drug discovery. Trends in Molecular Medicine, 7(7), 314-319.
35. Riedl, S.J., & Shi, Y. (2004). Molecular mechanisms of caspase regulation during apoptosis. Nature Reviews: Molecular Cell Biology, 5(11), 897-907.
36. Sforcin, J.M., Fernandes Jr, A., Lopes, C.A.M., Bankova, V., & Funari, S.R.C. (2000). Seasonal effect on Brazilian propolis antibacterial activity. Journal of Ethnopharmacology, 73(1-2), 243-249.
37. Simões, L.M.C., Gregó rio, L.E., Da Silva Filho, A.A., De Souza, M.L., Azzolini, A.E.C.S., Bastos, J.K., et al. (2004). Effect of Brazilian green propolis on the production of reactive oxygen species by stimulated neutrophils. Journal of Ethnopharmacology, 94(1), 59-65.
38. Tsujimoto, Y., & Shimizu, S. (2000). Bcl-2: Life-or-death switch. FEBS Letters, 466(1), 6-10.
39. Vaux, D.L., & Korsmeyer, S.J. (1999). Cell death in development. Cell, 96(2), 245-254.
40. Wang, X. (2001). The expanding role of mitochondria in apoptosis. Genes & Development, 15(22), 2922-2933.
41. Yoo, B.S., Jung, K.H., Han, S.B., & Kim, H.M. (1997). Apoptosis-mediated immunotoxicity of polychlorinated biphenyls (PCBs) in murine splenocytes. Toxicology Letters, 91(2), 83-89.
42. Yu, R., Mandlekar, S., Harvey, K.J., Ucker, D.S., & Kong, A.N. (1998). Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Research, 58(3), 402-408.