A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5664-5673

  Pandya, Renuka K ^a   Partridge, James R ^b   Love, Kerry Routenberg ^a,c   Schwartz, Thomas U ^b   Ploegh, Hidde L ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC DOMAINS; CATALYTIC SITES; CELLULAR PROCESS; E3 LIGASE; E3 UBIQUITIN LIGASES; LIGASE ACTIVITY; LIGASES; N-TERMINAL HELIX; STRUCTURAL ELEMENTS; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITINATION;

ENZYMES;

SUBSTRATES;

PROTEIN HUWE1; PROTEIN MCL 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; HUWE1 PROTEIN, HUMAN; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEIN BCL 2; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN DOMAIN; UBIQUITINATION; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-BCL-2; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 77949323346     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.051805     Document Type: Article

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